Blue rubber bleb nevus syndrome medical therapy: Difference between revisions
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== Medical Therapy == | == Medical Therapy == | ||
* Pharmacologic medical therapies for [[blue rubber bleb nevus syndrome]] include:<ref name="pmid19958301">{{cite journal |vauthors=Agnese M, Cipolletta L, Bianco MA, Quitadamo P, Miele E, Staiano A |title=Blue rubber bleb nevus syndrome |journal=Acta Paediatr. |volume=99 |issue=4 |pages=632–5 |date=April 2010 |pmid=19958301 |doi=10.1111/j.1651-2227.2009.01608.x |url=}}</ref> | * Pharmacologic medical therapies for [[blue rubber bleb nevus syndrome]] include:<ref name="pmid19958301">{{cite journal |vauthors=Agnese M, Cipolletta L, Bianco MA, Quitadamo P, Miele E, Staiano A |title=Blue rubber bleb nevus syndrome |journal=Acta Paediatr. |volume=99 |issue=4 |pages=632–5 |date=April 2010 |pmid=19958301 |doi=10.1111/j.1651-2227.2009.01608.x |url=}}</ref><ref name="pmid9795507">{{cite journal |vauthors=Jain A, Kar P, Chander R, Khandpur S, Jain S, Prabhash K, Gangwal P |title=Blue rubber bleb nevus syndrome: a cause of gastrointestinal hemorrhage |journal=Indian J Gastroenterol |volume=17 |issue=4 |pages=153–4 |date=1998 |pmid=9795507 |doi= |url=}}</ref> | ||
* [[Interferon-beta]] | * [[Interferon-beta]] | ||
** Preferred regimen (1): [[Interferon-beta]] 100 mg PO q12h for 10-21 days | |||
* [[Octreotide]] | * [[Octreotide]] | ||
* [[Sirolimus]] <ref name="pmid27820137">{{cite journal |vauthors=Ünlüsoy Aksu A, Sari S, Eğritaş Gürkan Ö, Dalgiç B |title=Favorable Response to Sirolimus in a Child With Blue Rubber Bleb Nevus Syndrome in the Gastrointestinal Tract |journal=J. Pediatr. Hematol. Oncol. |volume=39 |issue=2 |pages=147–149 |date=March 2017 |pmid=27820137 |doi=10.1097/MPH.0000000000000681 |url=}}</ref> | * [[Sirolimus]] <ref name="pmid27820137">{{cite journal |vauthors=Ünlüsoy Aksu A, Sari S, Eğritaş Gürkan Ö, Dalgiç B |title=Favorable Response to Sirolimus in a Child With Blue Rubber Bleb Nevus Syndrome in the Gastrointestinal Tract |journal=J. Pediatr. Hematol. Oncol. |volume=39 |issue=2 |pages=147–149 |date=March 2017 |pmid=27820137 |doi=10.1097/MPH.0000000000000681 |url=}}</ref> | ||
Revision as of 18:13, 20 December 2018
Overview
The mainstay of treatment for blue rubber bleb nevus syndrome is interferon-beta, octreotide, iron supplementation and blood transfusions.
Medical Therapy
- Pharmacologic medical therapies for blue rubber bleb nevus syndrome include:[1][2]
- Interferon-beta
- Preferred regimen (1): Interferon-beta 100 mg PO q12h for 10-21 days
- Octreotide
- Sirolimus [3]
- Iron supplementation
- Blood transfusions
- Corticosteroids
- Propranolol
- Thalidomide
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References
- ↑ Agnese M, Cipolletta L, Bianco MA, Quitadamo P, Miele E, Staiano A (April 2010). "Blue rubber bleb nevus syndrome". Acta Paediatr. 99 (4): 632–5. doi:10.1111/j.1651-2227.2009.01608.x. PMID 19958301.
- ↑ Jain A, Kar P, Chander R, Khandpur S, Jain S, Prabhash K, Gangwal P (1998). "Blue rubber bleb nevus syndrome: a cause of gastrointestinal hemorrhage". Indian J Gastroenterol. 17 (4): 153–4. PMID 9795507.
- ↑ Ünlüsoy Aksu A, Sari S, Eğritaş Gürkan Ö, Dalgiç B (March 2017). "Favorable Response to Sirolimus in a Child With Blue Rubber Bleb Nevus Syndrome in the Gastrointestinal Tract". J. Pediatr. Hematol. Oncol. 39 (2): 147–149. doi:10.1097/MPH.0000000000000681. PMID 27820137.