Rhabdomyosarcoma epidemiology and demographics: Difference between revisions
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*Almost 350 new cases of rhabdomyosarcoma are diagnosed annually.<ref name="pmid27955730" /> | *Almost 350 new cases of rhabdomyosarcoma are diagnosed annually.<ref name="pmid27955730" /> | ||
===Incidence=== | ===Incidence=== | ||
*The incidence of rhabdomyosarcomais about 0.43 | *The incidence of rhabdomyosarcomais about 0.43 per 100,000 annually among children,adolescents, and young adults under 20 years old.<ref name="pmid27955730" /> | ||
Incidence may depend on the histologic subtype of rhabdomyosarcoma:<ref name="pmid19536876">{{cite journal| author=Ognjanovic S, Linabery AM, Charbonneau B, Ross JA| title=Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005. | journal=Cancer | year= 2009 | volume= 115 | issue= 18 | pages= 4218-26 | pmid=19536876 | doi=10.1002/cncr.24465 | pmc=2953716 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19536876 }}</ref> | |||
*Embryonal rhabdomyosarcoma: Embryonal rhabdomyosarcoma peaks in 0 to 4 year age group at approximately 0.4 cases per 100,000 children, with a lower rate in adolescents, approximately 0.15 cases per 100,000 adolescents. | *Embryonal rhabdomyosarcoma: Embryonal rhabdomyosarcoma peaks in 0 to 4 year age group at approximately 0.4 cases per 100,000 children, with a lower rate in adolescents, approximately 0.15 cases per 100,000 adolescents. | ||
*Alveolar rhabdomyosarcoma: The incidence of alveolar rhabdomyosarcoma does not vary by gender and is constant from ages 0 to 19 years at approximately 0.1 case per 100,000 children and adolescents. | *Alveolar rhabdomyosarcoma: The incidence of alveolar rhabdomyosarcoma does not vary by gender and is constant from ages 0 to 19 years at approximately 0.1 case per 100,000 children and adolescents. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Epidemiology and Demographics
- Rhabdomyosarcoma is considered as a most common soft tissue cancers among children and adolescents and it is the third most common extracranial solid tumors during childhood which comes after neuroblastomaand wilms tumor.[1][2]
- Rhabdomyosarcoma is responsible for 50% of soft tissue tumors during childhood and 5% of all pediatrics cancers.[3]
- Almost 350 new cases of rhabdomyosarcoma are diagnosed annually.[1]
Incidence
- The incidence of rhabdomyosarcomais about 0.43 per 100,000 annually among children,adolescents, and young adults under 20 years old.[1]
Incidence may depend on the histologic subtype of rhabdomyosarcoma:[4]
- Embryonal rhabdomyosarcoma: Embryonal rhabdomyosarcoma peaks in 0 to 4 year age group at approximately 0.4 cases per 100,000 children, with a lower rate in adolescents, approximately 0.15 cases per 100,000 adolescents.
- Alveolar rhabdomyosarcoma: The incidence of alveolar rhabdomyosarcoma does not vary by gender and is constant from ages 0 to 19 years at approximately 0.1 case per 100,000 children and adolescents.
- Undifferentiated sarcoma: Infants younger than 1 year have a higher incidence of undifferentiated sarcoma.
Age
In general, rhabdomyosarcoma tends to affect individuals less than 45 years of age.
- Rhabdomyosarcoma is most commonly seen in children aged one to five years old. Overall, 65% of all rhabdomyosarcomas are diagnosed in patients under 10 years old.
- Less commonly, it can also present in teens aged 15 to 19, and can even develop in adulthood, though this is even more rare.
References
- ↑ 1.0 1.1 1.2 Dasgupta R, Fuchs J, Rodeberg D (2016). "Rhabdomyosarcoma". Semin Pediatr Surg. 25 (5): 276–283. doi:10.1053/j.sempedsurg.2016.09.011. PMID 27955730.
- ↑ Arndt CA, Crist WM (1999). "Common musculoskeletal tumors of childhood and adolescence". N Engl J Med. 341 (5): 342–52. doi:10.1056/NEJM199907293410507. PMID 10423470.
- ↑ Dasgupta R, Rodeberg DA (2012). "Update on rhabdomyosarcoma". Semin Pediatr Surg. 21 (1): 68–78. doi:10.1053/j.sempedsurg.2011.10.007. PMID 22248972.
- ↑ Ognjanovic S, Linabery AM, Charbonneau B, Ross JA (2009). "Trends in childhood rhabdomyosarcoma incidence and survival in the United States, 1975-2005". Cancer. 115 (18): 4218–26. doi:10.1002/cncr.24465. PMC 2953716. PMID 19536876.