Pseudomyxoma peritonei medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
Pseudomyxoma peritonei (PMP) is a rare condition consisting of intraperitoneal mucinous tumors and ascites, most commonly arises from mucinous tumors of the appendix and less commonly from ovary and colon. Pseudomyxoma peritonei symptoms include abdominal distention, bloating, hernia, infertility. It is a very uncommon tumor with an incident of 0.1 people per 100,000 per year prevalence, slightly more common in female wiht median age of 50 years old at the time of diagnosis. Prognosis is very optimal and good in general. It is a slowly progressive disease process with a large amount of mucus containing occasional epithelial cells. PMP is histologically classified into disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinomatosis (PMCA). Mainstay of treatment is cytoreduction surgery combined with | Pseudomyxoma peritonei (PMP) is a rare condition consisting of intraperitoneal mucinous tumors and ascites, most commonly arises from mucinous tumors of the appendix and less commonly from [[ovary]] and [[colon]]. Pseudomyxoma peritonei symptoms include abdominal distention, bloating, hernia, infertility. It is a very uncommon tumor with an incident of 0.1 people per 100,000 per year prevalence, slightly more common in female wiht median age of 50 years old at the time of diagnosis. Prognosis is very optimal and good in general. It is a slowly progressive disease process with a large amount of mucus containing occasional epithelial cells. PMP is histologically classified into [[disseminated peritoneal adenomucinosis]] (DPAM), peritoneal mucinous carcinomatosis (PMCA). Mainstay of treatment is cytoreduction surgery combined with [[hyperthermic intraperitoneal chemoperfusion]] (HIPEC). | ||
==Medical Therapy== | ==Medical Therapy== | ||
Mainstay of treatment for pseudomyxoma peritonei is cytoreductive surgery combined with intraperitoneal chemotherapy with mitomycin at 42°C.<ref name="ChenHuang2008">{{cite journal|last1=Chen|first1=Chin-Fan|last2=Huang|first2=Che-Jen|last3=Kang|first3=Wan-Yi|last4=Hsieh|first4=Jan-Sing|title=Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin / fluorouracil /leucovorin (FOLFOX4)|journal=World Journal of Surgical Oncology|volume=6|issue=1|year=2008|pages=118|issn=1477-7819|doi=10.1186/1477-7819-6-118}}</ref><ref name="Sugarbaker2006">{{cite journal|last1=Sugarbaker|first1=Paul H|title=New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome?|journal=The Lancet Oncology|volume=7|issue=1|year=2006|pages=69–76|issn=14702045|doi=10.1016/S1470-2045(05)70539-8}}</ref><ref name="pmid19567401">{{cite journal |vauthors=Vaira M, Cioppa T, DE Marco G, Bing C, D'Amico S, D'Alessandro M, Fiorentini G, DE Simone M |title=Management of pseudomyxoma peritonei by cytoreduction+HIPEC (hyperthermic intraperitoneal chemotherapy): results analysis of a twelve-year experience |journal=In Vivo |volume=23 |issue=4 |pages=639–44 |date=2009 |pmid=19567401 |doi= |url=}}</ref> | Mainstay of treatment for pseudomyxoma peritonei is cytoreductive surgery combined with intraperitoneal chemotherapy with [[mitomycin]] at 42°C.<ref name="ChenHuang2008">{{cite journal|last1=Chen|first1=Chin-Fan|last2=Huang|first2=Che-Jen|last3=Kang|first3=Wan-Yi|last4=Hsieh|first4=Jan-Sing|title=Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin / fluorouracil /leucovorin (FOLFOX4)|journal=World Journal of Surgical Oncology|volume=6|issue=1|year=2008|pages=118|issn=1477-7819|doi=10.1186/1477-7819-6-118}}</ref><ref name="Sugarbaker2006">{{cite journal|last1=Sugarbaker|first1=Paul H|title=New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome?|journal=The Lancet Oncology|volume=7|issue=1|year=2006|pages=69–76|issn=14702045|doi=10.1016/S1470-2045(05)70539-8}}</ref><ref name="pmid19567401">{{cite journal |vauthors=Vaira M, Cioppa T, DE Marco G, Bing C, D'Amico S, D'Alessandro M, Fiorentini G, DE Simone M |title=Management of pseudomyxoma peritonei by cytoreduction+HIPEC (hyperthermic intraperitoneal chemotherapy): results analysis of a twelve-year experience |journal=In Vivo |volume=23 |issue=4 |pages=639–44 |date=2009 |pmid=19567401 |doi= |url=}}</ref> | ||
== References == | == References == | ||
Revision as of 16:40, 22 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
Pseudomyxoma peritonei (PMP) is a rare condition consisting of intraperitoneal mucinous tumors and ascites, most commonly arises from mucinous tumors of the appendix and less commonly from ovary and colon. Pseudomyxoma peritonei symptoms include abdominal distention, bloating, hernia, infertility. It is a very uncommon tumor with an incident of 0.1 people per 100,000 per year prevalence, slightly more common in female wiht median age of 50 years old at the time of diagnosis. Prognosis is very optimal and good in general. It is a slowly progressive disease process with a large amount of mucus containing occasional epithelial cells. PMP is histologically classified into disseminated peritoneal adenomucinosis (DPAM), peritoneal mucinous carcinomatosis (PMCA). Mainstay of treatment is cytoreduction surgery combined with hyperthermic intraperitoneal chemoperfusion (HIPEC).
Medical Therapy
Mainstay of treatment for pseudomyxoma peritonei is cytoreductive surgery combined with intraperitoneal chemotherapy with mitomycin at 42°C.[1][2][3]
References
- ↑ Chen, Chin-Fan; Huang, Che-Jen; Kang, Wan-Yi; Hsieh, Jan-Sing (2008). "Experience with adjuvant chemotherapy for pseudomyxoma peritonei secondary to mucinous adenocarcinoma of the appendix with oxaliplatin / fluorouracil /leucovorin (FOLFOX4)". World Journal of Surgical Oncology. 6 (1): 118. doi:10.1186/1477-7819-6-118. ISSN 1477-7819.
- ↑ Sugarbaker, Paul H (2006). "New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome?". The Lancet Oncology. 7 (1): 69–76. doi:10.1016/S1470-2045(05)70539-8. ISSN 1470-2045.
- ↑ Vaira M, Cioppa T, DE Marco G, Bing C, D'Amico S, D'Alessandro M, Fiorentini G, DE Simone M (2009). "Management of pseudomyxoma peritonei by cytoreduction+HIPEC (hyperthermic intraperitoneal chemotherapy): results analysis of a twelve-year experience". In Vivo. 23 (4): 639–44. PMID 19567401.