Testicular cancer differential diagnosis: Difference between revisions

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Revision as of 15:42, 23 January 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

Testicular cancer must be differentiated from epididymitis, hematocele, hydrocele, spermatocele, granulomatous orchitis, and varicocele.

Differentiating Testicular cancer from other Diseases

Testicular cancer must be differentiated from:

									Pain	Mass	Physical examination	Lab Findings	Imaging
Diseases		Benign/ Malignant	Unilateral/Bilateral	History	Demography	Metastasis	Genetics	Histopathology	Clinical manifestations			Para-clinical findings
									Pain	Mass	Physical examination	Para-clinical findings
Germ Cell	Seminoma^[1]	Malignant	Unilateral	History of cryptorchidism Excellent prognosis	Most common among age of 15-35 years old Does not occur during infancy	Late metastasis	Stains positively for ALP, c-KIT, CD30, EMA, and glycogen	Large cells wit watery cytoplasm Fried egg appearance	-	+	Palpable, nontender unilateral testicular mass Usually homogeneous enlargement	Elevated serum placental ALP (PALP)	Ultrasound: Homogeneous hypoechoic intratesticular mass Cysts and calcificications are uncommon Inhomogenous feature in larger mass
	Embryonal carcinoma
	Yolk sac tumor
	Teratoma
	Choriocarcinoma
Diseases		Benign/ Malignant	Unilateral/Bilateral	History	Demography	Metastasis	Genetics		Pain	Mass	Physical exam	Lab Findings	Imaging
Non germ cell	Leydig cell tumor
	Sertoli cell tumor
	Testicular lymphoma
Carcinoma in situ of the testicle

References

↑ Miller FH, Whitney WS, Fitzgerald SW, Miller EI (1999). "Seminomas complicating undescended intraabdominal testes in patients with prior negative findings from surgical exploration". AJR Am J Roentgenol. 172 (2): 425–8. doi:10.2214/ajr.172.2.9930796. PMID 9930796.

Template:WikiDoc Sources

[pmid9930796-1] Miller FH, Whitney WS, Fitzgerald SW, Miller EI (1999). "Seminomas complicating undescended intraabdominal testes in patients with prior negative findings from surgical exploration". AJR Am J Roentgenol. 172 (2): 425–8. doi:10.2214/ajr.172.2.9930796. PMID 9930796.

[1]

@@ Line 16: / Line 16: @@
 ! rowspan="3" |Metastasis
 ! rowspan="3" |Genetics
+! rowspan="3" |Histopathology
 | style="background: #4479BA; color: #FFFFFF; text-align: center;" rowspan="1" colspan="3" |'''Clinical manifestations'''
 ! rowspan="2" colspan="2" |Para-clinical findings
@@ Line 27: / Line 28: @@
 |-
 | style="background: #DCDCDC; padding: 5px; text-align: center;" rowspan="5" |Germ Cell
-| style="background: #DCDCDC; padding: 5px; text-align: center;" |Seminoma
+| style="background: #DCDCDC; padding: 5px; text-align: center;" |Seminoma<ref name="pmid9930796">{{cite journal| author=Miller FH, Whitney WS, Fitzgerald SW, Miller EI| title=Seminomas complicating undescended intraabdominal testes in patients with prior negative findings from surgical exploration. | journal=AJR Am J Roentgenol | year= 1999 | volume= 172 | issue= 2 | pages= 425-8 | pmid=9930796 | doi=10.2214/ajr.172.2.9930796 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9930796  }}</ref>
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |Malignant
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |Unilateral
-| style="background: #F5F5F5; padding: 5px;" |
+| style="background: #F5F5F5; padding: 5px;" |History of cryptorchidism
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
+Excellent prognosis
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
-| style="background: #F5F5F5; padding: 5px;" |
 | style="background: #F5F5F5; padding: 5px;" |
+* Most common among age of 15-35 years old
+* Does not occur during infancy
+| style="background: #F5F5F5; padding: 5px;" |Late metastasis
+| style="background: #F5F5F5; padding: 5px;" |Stains positively for ALP, c-KIT, CD30, EMA, and glycogen
+|
+* Large cells wit watery cytoplasm
+* Fried egg appearance
+| style="background: #F5F5F5; padding: 5px;" |-
+| style="background: #F5F5F5; padding: 5px;" | +
 | style="background: #F5F5F5; padding: 5px;" |
+* Palpable, nontender unilateral testicular mass
+* Usually homogeneous enlargement
+| style="background: #F5F5F5; padding: 5px;" |Elevated serum placental ALP (PALP)
+| style="background: #F5F5F5; padding: 5px;" |Ultrasound:
+Homogeneous hypoechoic intratesticular mass
+Cysts and calcificications are uncommon
+Inhomogenous feature in larger mass
 |-
 | style="background: #DCDCDC; padding: 5px; text-align: center;" | Embryonal carcinoma
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 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Metastasis
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Genetics
+!
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pain
 ! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Mass
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Testicular cancer differential diagnosis: Difference between revisions

Revision as of 15:42, 23 January 2019

Overview

Differentiating Testicular cancer from other Diseases

References

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