Folate deficiency diagnostic study of choice: Difference between revisions
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=== Study of choice === | === Study of choice === | ||
[Name of the investigation] must be performed when: | [Name of the investigation] must be performed when: | ||
* The patient presents with [symptom/sign 1], [symptom/sign 2], and [symptom/sign 3]. | * The patient presents with [symptom/sign 1], [symptom/sign 2], and [symptom/sign 3]. | ||
* A [name of test] is positive for [sign 1], [sign 2], and [sign 3] in the patient | * A [name of test] is positive for [sign 1], [sign 2], and [sign 3] in the patient | ||
OR | OR | ||
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There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency, <ref name="Snow1999">{{cite journal|last1=Snow|first1=Christopher F.|title=Laboratory Diagnosis of Vitamin B12 and Folate Deficiency|journal=Archives of Internal Medicine|volume=159|issue=12|year=1999|pages=1289|issn=0003-9926|doi=10.1001/archinte.159.12.1289}}</ref> but [[Homocysteine]] and [[methylmalonic acid]] levels can be helpful in confirmation.[[Homocysteine]] but not [[methylmalonic acid]] is increased in [[folate]] deficiency.<ref name="pmid10926922">{{cite journal| author=Klee GG| title=Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate. | journal=Clin Chem | year= 2000 | volume= 46 | issue= 8 Pt 2 | pages= 1277-83 | pmid=10926922 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10926922 }}</ref> | There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency, <ref name="Snow1999">{{cite journal|last1=Snow|first1=Christopher F.|title=Laboratory Diagnosis of Vitamin B12 and Folate Deficiency|journal=Archives of Internal Medicine|volume=159|issue=12|year=1999|pages=1289|issn=0003-9926|doi=10.1001/archinte.159.12.1289}}</ref> but [[Homocysteine]] and [[methylmalonic acid]] levels can be helpful in confirmation.[[Homocysteine]] but not [[methylmalonic acid]] is increased in [[folate]] deficiency.<ref name="pmid10926922">{{cite journal| author=Klee GG| title=Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate. | journal=Clin Chem | year= 2000 | volume= 46 | issue= 8 Pt 2 | pages= 1277-83 | pmid=10926922 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10926922 }}</ref> | ||
Investigations: | Investigations: | ||
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The various investigations must be performed in the following order: | The various investigations must be performed in the following order: | ||
* [Initial investigation] | * [Initial investigation] | ||
* [2nd investigation | * [2nd investigation | ||
There are no established criteria for the diagnosis of [disease name]. | There are no established criteria for the diagnosis of [disease name]. |
Revision as of 04:20, 30 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Diagnostic Study of Choice
Study of choice
[Name of the investigation] must be performed when:
- The patient presents with [symptom/sign 1], [symptom/sign 2], and [symptom/sign 3].
- A [name of test] is positive for [sign 1], [sign 2], and [sign 3] in the patient
OR
There is no single diagnostic study of choice for the diagnosis of [disease name].
OR
There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency, [1] but Homocysteine and methylmalonic acid levels can be helpful in confirmation.Homocysteine but not methylmalonic acid is increased in folate deficiency.[2]
Investigations:
- Among the patients who present with clinical signs of [disease name], the [investigation name] is the most specific test for the diagnosis.
- Among the patients who present with clinical signs of [disease name], the [investigation name] is the most sensitive test for diagnosis.
- Among the patients who present with clinical signs of [disease name], the [investigation name] is the most efficient test for diagnosis.
The comparison of various diagnostic studies for [disease name]
Test | Sensitivity | Specificity |
---|---|---|
Test 1 | ...% | ...% |
Test 2 | ...% | ...% |
[Name of test with higher sensitivity and specificity] is the preferred investigation based on the sensitivity and specificity
Diagnostic results
The following finding(s) on performing [investigation name] is(are) confirmatory for [disease name]:
- [Finding 1]
- [Finding 2]
Sequence of Diagnostic Studies
The [name of investigation] must be performed when:
- The patient presented with symptoms/signs 1, 2, and 3 as the first step of diagnosis.
- A positive [test] is detected in the patient, to confirm the diagnosis.
OR
The various investigations must be performed in the following order:
- [Initial investigation]
- [2nd investigation
There are no established criteria for the diagnosis of [disease name].
References
- ↑ Snow, Christopher F. (1999). "Laboratory Diagnosis of Vitamin B12 and Folate Deficiency". Archives of Internal Medicine. 159 (12): 1289. doi:10.1001/archinte.159.12.1289. ISSN 0003-9926.
- ↑ Klee GG (2000). "Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate". Clin Chem. 46 (8 Pt 2): 1277–83. PMID 10926922.