Folate deficiency diagnostic study of choice: Difference between revisions
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== Overview == | == Overview == | ||
There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency. | |||
== Diagnostic Study of Choice == | == Diagnostic Study of Choice == | ||
=== Study of choice === | === Study of choice === | ||
There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency, <ref name="Snow1999">{{cite journal|last1=Snow|first1=Christopher F.|title=Laboratory Diagnosis of Vitamin B12 and Folate Deficiency|journal=Archives of Internal Medicine|volume=159|issue=12|year=1999|pages=1289|issn=0003-9926|doi=10.1001/archinte.159.12.1289}}</ref> but [[Homocysteine]] and [[methylmalonic acid]] levels can be helpful in confirmation.[[Homocysteine]] but not [[methylmalonic acid]] is increased in [[folate]] deficiency.<ref name="pmid10926922">{{cite journal| author=Klee GG| title=Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate. | journal=Clin Chem | year= 2000 | volume= 46 | issue= 8 Pt 2 | pages= 1277-83 | pmid=10926922 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10926922 }}</ref> | There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency, <ref name="Snow1999">{{cite journal|last1=Snow|first1=Christopher F.|title=Laboratory Diagnosis of Vitamin B12 and Folate Deficiency|journal=Archives of Internal Medicine|volume=159|issue=12|year=1999|pages=1289|issn=0003-9926|doi=10.1001/archinte.159.12.1289}}</ref> but [[Homocysteine]] and [[methylmalonic acid]] levels can be helpful in confirmation.[[Homocysteine]] but not [[methylmalonic acid]] is increased in [[folate]] deficiency.<ref name="pmid10926922">{{cite journal| author=Klee GG| title=Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate. | journal=Clin Chem | year= 2000 | volume= 46 | issue= 8 Pt 2 | pages= 1277-83 | pmid=10926922 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10926922 }}</ref> | ||
===== Sequence of Diagnostic Studies ===== | ===== Sequence of Diagnostic Studies ===== | ||
The various investigations must be performed in the following order: | The various investigations must be performed in the following order: | ||
* | * CBC | ||
* | * Peripheral smear | ||
==References== | ==References== |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency.
Diagnostic Study of Choice
Study of choice
There is no single diagnostic study of choice or gold standard test for the diagnosis of folate deficiency, [1] but Homocysteine and methylmalonic acid levels can be helpful in confirmation.Homocysteine but not methylmalonic acid is increased in folate deficiency.[2]
Sequence of Diagnostic Studies
The various investigations must be performed in the following order:
- CBC
- Peripheral smear
References
- ↑ Snow, Christopher F. (1999). "Laboratory Diagnosis of Vitamin B12 and Folate Deficiency". Archives of Internal Medicine. 159 (12): 1289. doi:10.1001/archinte.159.12.1289. ISSN 0003-9926.
- ↑ Klee GG (2000). "Cobalamin and folate evaluation: measurement of methylmalonic acid and homocysteine vs vitamin B(12) and folate". Clin Chem. 46 (8 Pt 2): 1277–83. PMID 10926922.