Endometrial cancer differential diagnosis: Difference between revisions

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| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Enlarged uterus
* Enlarged uterus
* Vaginal bleeding
* Vaginal bleeding
* Vaginal discharge
* Vaginal discharge
* Lymphadenopathy
* Lymphadenopathy
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| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Endometrial thickening
* Endometrial thickening
* Lymph node involvement
* Lymph node involvement
* Pelvic metastasis
* Pelvic metastasis
| style="background: #F5F5F5; padding: 5px;" |Atypical glandular cells   
| style="background: #F5F5F5; padding: 5px;" |Atypical glandular cells   
| style="background: #F5F5F5; padding: 5px;" |[[Malignant|Endometrial malignant cells]]:
| style="background: #F5F5F5; padding: 5px;" |[[Malignant|Endometrial malignant cells]]:
* Low grade  Type I
* Low grade  Type I
* High grade Type II
* High grade Type II
| style="background: #F5F5F5; padding: 5px;" |Histologic diagnosis
| style="background: #F5F5F5; padding: 5px;" |Histologic diagnosis
|-
|-
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Uterine sarcoma|Uterine]]
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Uterine sarcoma|Uterine]]
[[Leiomyosarcoma|leiomyosarcoma]]<ref name="pmid9291814">{{cite journal |vauthors=Nordal RR, Thoresen SO |title=Uterine sarcomas in Norway 1956-1992: incidence, survival and mortality |journal=Eur. J. Cancer |volume=33 |issue=6 |pages=907–11 |date=May 1997 |pmid=9291814 |doi= |url=}}</ref>
[[Leiomyosarcoma|leiomyosarcoma]]<ref name="pmid9291814">{{cite journal |vauthors=Nordal RR, Thoresen SO |title=Uterine sarcomas in Norway 1956-1992: incidence, survival and mortality |journal=Eur. J. Cancer |volume=33 |issue=6 |pages=907–11 |date=May 1997 |pmid=9291814 |doi= |url=}}</ref><ref name="pmid12144683">{{cite journal |vauthors=Goto A, Takeuchi S, Sugimura K, Maruo T |title=Usefulness of Gd-DTPA contrast-enhanced dynamic MRI and serum determination of LDH and its isozymes in the differential diagnosis of leiomyosarcoma from degenerated leiomyoma of the uterus |journal=Int. J. Gynecol. Cancer |volume=12 |issue=4 |pages=354–61 |date=2002 |pmid=12144683 |doi= |url=}}</ref><ref name="pmid8179071">{{cite journal |vauthors=Bell SW, Kempson RL, Hendrickson MR |title=Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases |journal=Am. J. Surg. Pathol. |volume=18 |issue=6 |pages=535–58 |date=June 1994 |pmid=8179071 |doi= |url=}}</ref><ref name="pmid20882892">{{cite journal |vauthors=Karpathiou G, Sivridis E, Giatromanolaki A |title=Myxoid leiomyosarcoma of the uterus: a diagnostic challenge |journal=Eur. J. Gynaecol. Oncol. |volume=31 |issue=4 |pages=446–8 |date=2010 |pmid=20882892 |doi= |url=}}</ref>
 
<ref name="pmid12144683">{{cite journal |vauthors=Goto A, Takeuchi S, Sugimura K, Maruo T |title=Usefulness of Gd-DTPA contrast-enhanced dynamic MRI and serum determination of LDH and its isozymes in the differential diagnosis of leiomyosarcoma from degenerated leiomyoma of the uterus |journal=Int. J. Gynecol. Cancer |volume=12 |issue=4 |pages=354–61 |date=2002 |pmid=12144683 |doi= |url=}}</ref><ref name="pmid8179071">{{cite journal |vauthors=Bell SW, Kempson RL, Hendrickson MR |title=Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases |journal=Am. J. Surg. Pathol. |volume=18 |issue=6 |pages=535–58 |date=June 1994 |pmid=8179071 |doi= |url=}}</ref><ref name="pmid20882892">{{cite journal |vauthors=Karpathiou G, Sivridis E, Giatromanolaki A |title=Myxoid leiomyosarcoma of the uterus: a diagnostic challenge |journal=Eur. J. Gynaecol. Oncol. |volume=31 |issue=4 |pages=446–8 |date=2010 |pmid=20882892 |doi= |url=}}</ref>
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* May have menorrhagia
* May have menorrhagia
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| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Enlarged or normal sized [[uterus]]
* Enlarged or normal sized [[uterus]]
* [[Lymphadenopathy]]
* [[Lymphadenopathy]]
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
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| style="background: #F5F5F5; padding: 5px;" |Histologic diagnosis
| style="background: #F5F5F5; padding: 5px;" |Histologic diagnosis
|-
|-
!Diseases
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
! colspan="1" rowspan="1" |Bleeding
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
!Pelvic Pain/pressure/
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic Pain/pressure/
discomfort
discomfort
!Other
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
!Pelvic examination
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic examination
! colspan="1" rowspan="1" |Abdominal examination
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal examination
!Hb
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb
!B-HCG
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |B-HCG
!CA-125
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |CA-125
!Ultrasound
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ultrasound
!MRI
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |MRI
!Pap Smear
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pap Smear
!Histopathology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology
!Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
|-
|-
! style="background: #DCDCDC; padding: 5px; text-align: center;" |Uterine [[leiomyoma]]<ref name="pmid25901428">{{cite journal |vauthors=Stewart EA |title=Clinical practice. Uterine fibroids |journal=N. Engl. J. Med. |volume=372 |issue=17 |pages=1646–55 |date=April 2015 |pmid=25901428 |doi=10.1056/NEJMcp1411029 |url=}}</ref>
! style="background: #DCDCDC; padding: 5px; text-align: center;" |Uterine [[leiomyoma]]<ref name="pmid25901428">{{cite journal |vauthors=Stewart EA |title=Clinical practice. Uterine fibroids |journal=N. Engl. J. Med. |volume=372 |issue=17 |pages=1646–55 |date=April 2015 |pmid=25901428 |doi=10.1056/NEJMcp1411029 |url=}}</ref><ref name="pmid11904599">{{cite journal |vauthors=Dueholm M, Lundorf E, Hansen ES, Ledertoug S, Olesen F |title=Accuracy of magnetic resonance imaging and transvaginal ultrasonography in the diagnosis, mapping, and measurement of uterine myomas |journal=Am. J. Obstet. Gynecol. |volume=186 |issue=3 |pages=409–15 |date=March 2002 |pmid=11904599 |doi= |url=}}</ref><ref name="pmid12427815">{{cite journal |vauthors=Omary RA, Vasireddy S, Chrisman HB, Ryu RK, Pereles FS, Carr JC, Resnick SA, Nemcek AA, Vogelzang RL |title=The effect of pelvic MR imaging on the diagnosis and treatment of women with presumed symptomatic uterine fibroids |journal=J Vasc Interv Radiol |volume=13 |issue=11 |pages=1149–53 |date=November 2002 |pmid=12427815 |doi= |url=}}</ref>
 
<ref name="pmid11904599">{{cite journal |vauthors=Dueholm M, Lundorf E, Hansen ES, Ledertoug S, Olesen F |title=Accuracy of magnetic resonance imaging and transvaginal ultrasonography in the diagnosis, mapping, and measurement of uterine myomas |journal=Am. J. Obstet. Gynecol. |volume=186 |issue=3 |pages=409–15 |date=March 2002 |pmid=11904599 |doi= |url=}}</ref><ref name="pmid12427815">{{cite journal |vauthors=Omary RA, Vasireddy S, Chrisman HB, Ryu RK, Pereles FS, Carr JC, Resnick SA, Nemcek AA, Vogelzang RL |title=The effect of pelvic MR imaging on the diagnosis and treatment of women with presumed symptomatic uterine fibroids |journal=J Vasc Interv Radiol |volume=13 |issue=11 |pages=1149–53 |date=November 2002 |pmid=12427815 |doi= |url=}}</ref>
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* May have menorrhagia
* May have menorrhagia
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** Location
** Location
** Numbers
** Numbers
* Shows "popcorn" calcification in the fibroid (degeneration)
* Shows "popcorn" calcification in the fibroid (degeneration)
* Differentiaites between leiomyomas, adenomyosisand adenomyomas
* Differentiaites between leiomyomas, adenomyosisand adenomyomas
| style="background: #F5F5F5; padding: 5px;" |Normal
| style="background: #F5F5F5; padding: 5px;" |Normal
| style="background: #F5F5F5; padding: 5px;" |Normal appearing bundle of epithiloid shape smooth muscle cells with normal mitotic index
| style="background: #F5F5F5; padding: 5px;" |Normal appearing bundle of epithiloid shape smooth muscle cells with normal mitotic index
| style="background: #F5F5F5; padding: 5px;" |Imaging
| style="background: #F5F5F5; padding: 5px;" |Imaging and histologic analysis
 
and  
 
Histologic analysis
|-
|-
! style="background: #DCDCDC; padding: 5px; text-align: center;" |Uterine carcinosarcomas (Malignant mixed mullerian tumour (MMMT) of the uterus)<ref name="pmid27878502">{{cite journal |vauthors=Chaffer CL, San Juan BP, Lim E, Weinberg RA |title=EMT, cell plasticity and metastasis |journal=Cancer Metastasis Rev. |volume=35 |issue=4 |pages=645–654 |date=December 2016 |pmid=27878502 |doi=10.1007/s10555-016-9648-7 |url=}}</ref><ref name="pmid27791010">{{cite journal |vauthors=Zhao S, Bellone S, Lopez S, Thakral D, Schwab C, English DP, Black J, Cocco E, Choi J, Zammataro L, Predolini F, Bonazzoli E, Bi M, Buza N, Hui P, Wong S, Abu-Khalaf M, Ravaggi A, Bignotti E, Bandiera E, Romani C, Todeschini P, Tassi R, Zanotti L, Odicino F, Pecorelli S, Donzelli C, Ardighieri L, Facchetti F, Falchetti M, Silasi DA, Ratner E, Azodi M, Schwartz PE, Mane S, Angioli R, Terranova C, Quick CM, Edraki B, Bilgüvar K, Lee M, Choi M, Stiegler AL, Boggon TJ, Schlessinger J, Lifton RP, Santin AD |title=Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=113 |issue=43 |pages=12238–12243 |date=October 2016 |pmid=27791010 |pmc=5087050 |doi=10.1073/pnas.1614120113 |url=}}</ref><ref name="pmid14967435">{{cite journal |vauthors=Callister M, Ramondetta LM, Jhingran A, Burke TW, Eifel PJ |title=Malignant mixed Müllerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome |journal=Int. J. Radiat. Oncol. Biol. Phys. |volume=58 |issue=3 |pages=786–96 |date=March 2004 |pmid=14967435 |doi=10.1016/S0360-3016(03)01561-X |url=}}</ref><ref name="pmid18562759">{{cite journal |vauthors=Teo SY, Babagbemi KT, Peters HE, Mortele KJ |title=Primary malignant mixed mullerian tumor of the uterus: findings on sonography, CT, and gadolinium-enhanced MRI |journal=AJR Am J Roentgenol |volume=191 |issue=1 |pages=278–83 |date=July 2008 |pmid=18562759 |doi=10.2214/AJR.07.3281 |url=}}</ref>
! style="background: #DCDCDC; padding: 5px; text-align: center;" |Uterine carcinosarcomas (Malignant mixed mullerian tumour (MMMT) of the uterus)<ref name="pmid27878502">{{cite journal |vauthors=Chaffer CL, San Juan BP, Lim E, Weinberg RA |title=EMT, cell plasticity and metastasis |journal=Cancer Metastasis Rev. |volume=35 |issue=4 |pages=645–654 |date=December 2016 |pmid=27878502 |doi=10.1007/s10555-016-9648-7 |url=}}</ref><ref name="pmid27791010">{{cite journal |vauthors=Zhao S, Bellone S, Lopez S, Thakral D, Schwab C, English DP, Black J, Cocco E, Choi J, Zammataro L, Predolini F, Bonazzoli E, Bi M, Buza N, Hui P, Wong S, Abu-Khalaf M, Ravaggi A, Bignotti E, Bandiera E, Romani C, Todeschini P, Tassi R, Zanotti L, Odicino F, Pecorelli S, Donzelli C, Ardighieri L, Facchetti F, Falchetti M, Silasi DA, Ratner E, Azodi M, Schwartz PE, Mane S, Angioli R, Terranova C, Quick CM, Edraki B, Bilgüvar K, Lee M, Choi M, Stiegler AL, Boggon TJ, Schlessinger J, Lifton RP, Santin AD |title=Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=113 |issue=43 |pages=12238–12243 |date=October 2016 |pmid=27791010 |pmc=5087050 |doi=10.1073/pnas.1614120113 |url=}}</ref><ref name="pmid14967435">{{cite journal |vauthors=Callister M, Ramondetta LM, Jhingran A, Burke TW, Eifel PJ |title=Malignant mixed Müllerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome |journal=Int. J. Radiat. Oncol. Biol. Phys. |volume=58 |issue=3 |pages=786–96 |date=March 2004 |pmid=14967435 |doi=10.1016/S0360-3016(03)01561-X |url=}}</ref><ref name="pmid18562759">{{cite journal |vauthors=Teo SY, Babagbemi KT, Peters HE, Mortele KJ |title=Primary malignant mixed mullerian tumor of the uterus: findings on sonography, CT, and gadolinium-enhanced MRI |journal=AJR Am J Roentgenol |volume=191 |issue=1 |pages=278–83 |date=July 2008 |pmid=18562759 |doi=10.2214/AJR.07.3281 |url=}}</ref>
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* Enlarged uterine cavity
* Enlarged uterine cavity
* Hyperechoic mass in uterus and cervix
* Hyperechoic mass in uterus and cervix
| style="background: #F5F5F5; padding: 5px;" |Heterogenous bulky polypoid mass
| style="background: #F5F5F5; padding: 5px;" |Heterogenous bulky polypoid mass with intense enhancement
 
with intense enhancement
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |Biphasic (carcinoma/sarcoma combination) and contains:
| style="background: #F5F5F5; padding: 5px;" |Biphasic (carcinoma/sarcoma combination) and contains:
* High grade carcinomatous (epithelial) contents
* High grade carcinomatous (epithelial) contents
* Stromal sarcomatous (connective tissue)
* Stromal sarcomatous (connective tissue)
| style="background: #F5F5F5; padding: 5px;" |Histologic diagnosis
| style="background: #F5F5F5; padding: 5px;" |Histologic diagnosis
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| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Enlarged uterus
* Enlarged uterus
* Concomitant cervical lesions
* Concomitant cervical lesions
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
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| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
Pap test is done simultaneously with HPV testing, if cervical cancer is suspected.
Pap test is done simultaneously with HPV testing, if cervical cancer is suspected.
Abnormal pap test may show two type of abnormal cells:
Abnormal pap test may show two type of abnormal cells:
* [[Squamous cell carcinoma|Squamous cell carcinoma]]
* [[Squamous cell carcinoma|Squamous cell carcinoma]]
** Low-grade squamous intraepithelial lesions (LSILs)
** Low-grade squamous intraepithelial lesions (LSILs)
** High-grade squamous intraepithelial lesions (HSILs)
** High-grade squamous intraepithelial lesions (HSILs)
* [[Adenocarcinoma|Adenocarcinoma]]
* [[Adenocarcinoma|Adenocarcinoma]]
** Atypical glandular cells (AGC)
** Atypical glandular cells (AGC)
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| style="background: #F5F5F5; padding: 5px;" |If pap test shows abnormal results. [[Colposcopy]] and [[biopsy]] is done. Histologic types are
| style="background: #F5F5F5; padding: 5px;" |If pap test shows abnormal results. [[Colposcopy]] and [[biopsy]] is done. Histologic types are
* [[Squamous cell carcinoma]]  
* [[Squamous cell carcinoma]]  
* [[Adenocarcinoma]]  
* [[Adenocarcinoma]]  
* [[Cervical cancer|Adenosquamous tumors]]
* [[Cervical cancer|Adenosquamous tumors]]
| style="background: #F5F5F5; padding: 5px;" |Histologic diagnosis
| style="background: #F5F5F5; padding: 5px;" |Histologic diagnosis
|-
|-
!Diseases
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
! colspan="1" rowspan="1" |Bleeding
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
!Pelvic Pain/pressure/
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic Pain/pressure/
discomfort
discomfort
!Other
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
!Pelvic examination
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic examination
! colspan="1" rowspan="1" |Abdominal examination
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal examination
!Hb
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb
!B-HCG
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |B-HCG
!CA-125
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |CA-125
!Ultrasound
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ultrasound
!MRI
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |MRI
!Pap Smear
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pap Smear
!Histopathology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology
!Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
|-
|-
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Metastasis]]
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Metastasis]]
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| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Asymptomatic
* Asymptomatic
* Obstetric complications
* Obstetric complications
* [[Dysmenorrhea]] (most common symptoms)
* [[Dysmenorrhea]] (most common symptoms)
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|-
|-
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Endometrial polyp|Endometrial]]
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Endometrial polyp|Endometrial]]
[[Endometrial polyp|polyp]]<ref name="pmid15252313">{{cite journal |vauthors=Kim KR, Peng R, Ro JY, Robboy SJ |title=A diagnostically useful histopathologic feature of endometrial polyp: the long axis of endometrial glands arranged parallel to surface epithelium |journal=Am. J. Surg. Pathol. |volume=28 |issue=8 |pages=1057–62 |date=August 2004 |pmid=15252313 |doi= |url=}}</ref>
[[Endometrial polyp|polyp]]<ref name="pmid15252313">{{cite journal |vauthors=Kim KR, Peng R, Ro JY, Robboy SJ |title=A diagnostically useful histopathologic feature of endometrial polyp: the long axis of endometrial glands arranged parallel to surface epithelium |journal=Am. J. Surg. Pathol. |volume=28 |issue=8 |pages=1057–62 |date=August 2004 |pmid=15252313 |doi= |url=}}</ref><ref name="pmid21783430">{{cite journal |vauthors=Salim S, Won H, Nesbitt-Hawes E, Campbell N, Abbott J |title=Diagnosis and management of endometrial polyps: a critical review of the literature |journal=J Minim Invasive Gynecol |volume=18 |issue=5 |pages=569–81 |date=2011 |pmid=21783430 |doi=10.1016/j.jmig.2011.05.018 |url=}}</ref>
 
<ref name="pmid21783430">{{cite journal |vauthors=Salim S, Won H, Nesbitt-Hawes E, Campbell N, Abbott J |title=Diagnosis and management of endometrial polyps: a critical review of the literature |journal=J Minim Invasive Gynecol |volume=18 |issue=5 |pages=569–81 |date=2011 |pmid=21783430 |doi=10.1016/j.jmig.2011.05.018 |url=}}</ref>
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Menorrhagia
* Menorrhagia
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| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Asymptomatic
* Asymptomatic
* Endometrial polyp prolapses (will be visible on speculum examination protruding through cervical os)
* Endometrial polyp prolapses (will be visible on speculum examination protruding through cervical os)
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Normal sized uterus with smooth surface
* Normal sized uterus with smooth surface
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| style="background: #F5F5F5; padding: 5px;" |[[Anemia|↓]]
| style="background: #F5F5F5; padding: 5px;" |[[Anemia|↓]]
| style="background: #F5F5F5; padding: 5px;" | –
| style="background: #F5F5F5; padding: 5px;" | –
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | + or Nl
 
or
 
N
| style="background: #F5F5F5; padding: 5px;" |Incidentally on pelvic ultrasound (most common)
| style="background: #F5F5F5; padding: 5px;" |Incidentally on pelvic ultrasound (most common)
| style="background: #F5F5F5; padding: 5px;" |MRI will show polyp size and dimension in detail but it is usually is not required for its diagnoses.
| style="background: #F5F5F5; padding: 5px;" |MRI will show polyp size and dimension in detail but it is usually is not required for its diagnoses.
| style="background: #F5F5F5; padding: 5px;" |Normal
| style="background: #F5F5F5; padding: 5px;" |Normal
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| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Imaging
* Imaging
* Histologic evaluation  
* Histologic evaluation  
|-
|-
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Endometrial hyperplasia|Endometrial]]
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Endometrial hyperplasia|Endometrial]]
[[Endometrial hyperplasia|hyperpalsia]]<ref name="pmid25797956">{{cite journal |vauthors=Emons G, Beckmann MW, Schmidt D, Mallmann P |title=New WHO Classification of Endometrial Hyperplasias |journal=Geburtshilfe Frauenheilkd |volume=75 |issue=2 |pages=135–136 |date=February 2015 |pmid=25797956 |pmc=4361167 |doi=10.1055/s-0034-1396256 |url=}}</ref>
[[Endometrial hyperplasia|hyperpalsia]]<ref name="pmid25797956">{{cite journal |vauthors=Emons G, Beckmann MW, Schmidt D, Mallmann P |title=New WHO Classification of Endometrial Hyperplasias |journal=Geburtshilfe Frauenheilkd |volume=75 |issue=2 |pages=135–136 |date=February 2015 |pmid=25797956 |pmc=4361167 |doi=10.1055/s-0034-1396256 |url=}}</ref><ref name="pmid17917566">{{cite journal |vauthors=Wright TC, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D |title=2006 consensus guidelines for the management of women with abnormal cervical screening tests |journal=J Low Genit Tract Dis |volume=11 |issue=4 |pages=201–22 |date=October 2007 |pmid=17917566 |doi=10.1097/LGT.0b013e3181585870 |url=}}</ref><ref name="pmid18061866">{{cite journal |vauthors=Espindola D, Kennedy KA, Fischer EG |title=Management of abnormal uterine bleeding and the pathology of endometrial hyperplasia |journal=Obstet. Gynecol. Clin. North Am. |volume=34 |issue=4 |pages=717–37, ix |date=December 2007 |pmid=18061866 |doi=10.1016/j.ogc.2007.09.001 |url=}}</ref><ref name="pmid15097798">{{cite journal |vauthors=Montgomery BE, Daum GS, Dunton CJ |title=Endometrial hyperplasia: a review |journal=Obstet Gynecol Surv |volume=59 |issue=5 |pages=368–78 |date=May 2004 |pmid=15097798 |doi= |url=}}</ref>
 
<ref name="pmid17917566">{{cite journal |vauthors=Wright TC, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D |title=2006 consensus guidelines for the management of women with abnormal cervical screening tests |journal=J Low Genit Tract Dis |volume=11 |issue=4 |pages=201–22 |date=October 2007 |pmid=17917566 |doi=10.1097/LGT.0b013e3181585870 |url=}}</ref><ref name="pmid18061866">{{cite journal |vauthors=Espindola D, Kennedy KA, Fischer EG |title=Management of abnormal uterine bleeding and the pathology of endometrial hyperplasia |journal=Obstet. Gynecol. Clin. North Am. |volume=34 |issue=4 |pages=717–37, ix |date=December 2007 |pmid=18061866 |doi=10.1016/j.ogc.2007.09.001 |url=}}</ref><ref name="pmid15097798">{{cite journal |vauthors=Montgomery BE, Daum GS, Dunton CJ |title=Endometrial hyperplasia: a review |journal=Obstet Gynecol Surv |volume=59 |issue=5 |pages=368–78 |date=May 2004 |pmid=15097798 |doi= |url=}}</ref>
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Menorrhagia
* Menorrhagia
Line 337: Line 302:
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Asymptomatic
* Asymptomatic
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Normal sized uterus with smooth surface
* Normal sized uterus with smooth surface
Line 352: Line 316:
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Endometrial sampling is used (gold standard) for the diagnosis of endometrial hyperplasia.
* Endometrial sampling is used (gold standard) for the diagnosis of endometrial hyperplasia.
* Biopsy and histology may show two types:
* Biopsy and histology may show two types:
** Non-neoplastic changes:
** Non-neoplastic changes:
Line 363: Line 326:
** Atypical complex hyperplasia
** Atypical complex hyperplasia
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
Histologic
Histologic diagnosis
 
diagnosis
|-
|-
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Adenomyoma|Uterine]]
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Adenomyoma|Uterine]]
[[Adenomyoma|adenomyoma]]
[[Adenomyoma|adenomyoma]]<ref name="pmid4608783">{{cite journal |vauthors=McElin TW, Bird CC |title=Adenomyosis of the uterus |journal=Obstet Gynecol Annu |volume=3 |issue= |pages=425–41 |date=1974 |pmid=4608783 |doi= |url=}}</ref><ref name="pmid22442261">{{cite journal |vauthors=Maheshwari A, Gurunath S, Fatima F, Bhattacharya S |title=Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes |journal=Hum. Reprod. Update |volume=18 |issue=4 |pages=374–92 |date=July 2012 |pmid=22442261 |doi=10.1093/humupd/dms006 |url=}}</ref><ref name="pmid10517452">{{cite journal |vauthors=Byun JY, Kim SE, Choi BG, Ko GY, Jung SE, Choi KH |title=Diffuse and focal adenomyosis: MR imaging findings |journal=Radiographics |volume=19 Spec No |issue= |pages=S161–70 |date=October 1999 |pmid=10517452 |doi=10.1148/radiographics.19.suppl_1.g99oc03s161 |url=}}</ref>
 
<ref name="pmid4608783">{{cite journal |vauthors=McElin TW, Bird CC |title=Adenomyosis of the uterus |journal=Obstet Gynecol Annu |volume=3 |issue= |pages=425–41 |date=1974 |pmid=4608783 |doi= |url=}}</ref><ref name="pmid22442261">{{cite journal |vauthors=Maheshwari A, Gurunath S, Fatima F, Bhattacharya S |title=Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes |journal=Hum. Reprod. Update |volume=18 |issue=4 |pages=374–92 |date=July 2012 |pmid=22442261 |doi=10.1093/humupd/dms006 |url=}}</ref>
 
<ref name="pmid10517452">{{cite journal |vauthors=Byun JY, Kim SE, Choi BG, Ko GY, Jung SE, Choi KH |title=Diffuse and focal adenomyosis: MR imaging findings |journal=Radiographics |volume=19 Spec No |issue= |pages=S161–70 |date=October 1999 |pmid=10517452 |doi=10.1148/radiographics.19.suppl_1.g99oc03s161 |url=}}</ref>
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" |±
| style="background: #F5F5F5; padding: 5px;" |±
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* [[Dysmenorrhea|Dysmenorrhea]]
* [[Dysmenorrhea|Dysmenorrhea]]
* Subfertility
* Subfertility
*
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Diffusely enlarged tender boggy uterus with smooth surface  
* Diffusely enlarged tender boggy uterus with smooth surface  
* Uterus may develop masses
* Uterus may develop masses
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Normal
* Normal
| style="background: #F5F5F5; padding: 5px;" |[[Anemia|↓]]
| style="background: #F5F5F5; padding: 5px;" |[[Anemia|↓]]
| style="background: #F5F5F5; padding: 5px;" | –
| style="background: #F5F5F5; padding: 5px;" | –
Line 393: Line 345:
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Snow storm appearance in diffuse adenomyosis
* Snow storm appearance in diffuse adenomyosis
* Shows a uterine mass in case of adenomas
* Shows a uterine mass in case of adenomas
| style="background: #F5F5F5; padding: 5px;" |Identifies diffuse or focal adenomyosis from leiomyoma
| style="background: #F5F5F5; padding: 5px;" |Identifies diffuse or focal adenomyosis from leiomyoma
Line 400: Line 351:
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Imaging
* Imaging
* Histologic
* Histologic
diagnosis
diagnosis
|-
|-
!Diseases
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
! colspan="1" rowspan="1" |Bleeding
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
!Pelvic Pain/pressure/
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic Pain/pressure/
discomfort
discomfort
!Other
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
!Pelvic examination
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic examination
! colspan="1" rowspan="1" |Abdominal examination
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal examination
!Hb
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb
!B-HCG
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |B-HCG
!CA-125
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |CA-125
!Ultrasound
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ultrasound
!MRI
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |MRI
!Pap Smear
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pap Smear
!Histopathology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology
!Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
|-
|-
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Hematometra|Hematometra]]
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Hematometra|Hematometra]] (blood within the uterine cavity)
(blood within the  
 
uterine cavity)
 
<ref name="pmid17630156">{{cite journal |vauthors=McCausland AM, McCausland VM |title=Long-term complications of endometrial ablation: cause, diagnosis, treatment, and prevention |journal=J Minim Invasive Gynecol |volume=14 |issue=4 |pages=399–406 |date=2007 |pmid=17630156 |doi=10.1016/j.jmig.2007.04.004 |url=}}</ref><ref name="pmid20606801">{{cite journal |vauthors=U Nayak A, Swarup A, G S J, N S |title=Hematometra and acute abdomen |journal=J Emerg Trauma Shock |volume=3 |issue=2 |pages=191–2 |date=April 2010 |pmid=20606801 |pmc=2884455 |doi=10.4103/0974-2700.62117 |url=}}</ref>
<ref name="pmid17630156">{{cite journal |vauthors=McCausland AM, McCausland VM |title=Long-term complications of endometrial ablation: cause, diagnosis, treatment, and prevention |journal=J Minim Invasive Gynecol |volume=14 |issue=4 |pages=399–406 |date=2007 |pmid=17630156 |doi=10.1016/j.jmig.2007.04.004 |url=}}</ref><ref name="pmid20606801">{{cite journal |vauthors=U Nayak A, Swarup A, G S J, N S |title=Hematometra and acute abdomen |journal=J Emerg Trauma Shock |volume=3 |issue=2 |pages=191–2 |date=April 2010 |pmid=20606801 |pmc=2884455 |doi=10.4103/0974-2700.62117 |url=}}</ref>
| style="background: #F5F5F5; padding: 5px;" | -
| style="background: #F5F5F5; padding: 5px;" | -
Line 432: Line 378:
* Cramping in pelvis  
* Cramping in pelvis  
* Cyclic pain
* Cyclic pain
* Dysmenorrhea
* Dysmenorrhea
* Amenorrhea
* Amenorrhea
* Hypotension
* Hypotension
* Vasovagal syncopy
* Vasovagal syncopy
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Firm and enlarged uterus
* Firm and enlarged uterus
* Adenaxal tenderness
* Adenaxal tenderness
* Pelvic examination may be restricted by pain
* Pelvic examination may be restricted by pain
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
Line 456: Line 397:
| style="background: #F5F5F5; padding: 5px;" |Ultrasound
| style="background: #F5F5F5; padding: 5px;" |Ultrasound
|-
|-
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Gestational trophoblastic disease|Gestational trophoblastic disease]]
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Gestational trophoblastic disease|Gestational trophoblastic disease]]<ref name="pmid8035373">{{cite journal |vauthors=Bakri YN, Berkowitz RS, Khan J, Goldstein DP, von Sinner W, Jabbar FA |title=Pulmonary metastases of gestational trophoblastic tumor. Risk factors for early respiratory failure |journal=J Reprod Med |volume=39 |issue=3 |pages=175–8 |date=March 1994 |pmid=8035373 |doi= |url=}}</ref><ref name="pmid20728069">{{cite journal |vauthors=Lurain JR |title=Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole |journal=Am. J. Obstet. Gynecol. |volume=203 |issue=6 |pages=531–9 |date=December 2010 |pmid=20728069 |doi=10.1016/j.ajog.2010.06.073 |url=}}</ref>
<ref name="pmid8035373">{{cite journal |vauthors=Bakri YN, Berkowitz RS, Khan J, Goldstein DP, von Sinner W, Jabbar FA |title=Pulmonary metastases of gestational trophoblastic tumor. Risk factors for early respiratory failure |journal=J Reprod Med |volume=39 |issue=3 |pages=175–8 |date=March 1994 |pmid=8035373 |doi= |url=}}</ref><ref name="pmid20728069">{{cite journal |vauthors=Lurain JR |title=Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole |journal=Am. J. Obstet. Gynecol. |volume=203 |issue=6 |pages=531–9 |date=December 2010 |pmid=20728069 |doi=10.1016/j.ajog.2010.06.073 |url=}}</ref>
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* May have menorrhagia
* May have menorrhagia
Line 468: Line 408:
** Cough
** Cough
** Hemoptysis
** Hemoptysis
* Vaginal metastases
* Vaginal metastases
** Vaginal bleeding
** Vaginal bleeding
Line 477: Line 416:
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Irregularly sized boggy enlarged uterus
* Irregularly sized boggy enlarged uterus
* Adnexal fullness
* Adnexal fullness
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
Line 486: Line 424:
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* US shows dilated grape like structures  
* US shows dilated grape like structures  
* Diffuse hydropic swelling
* Diffuse hydropic swelling
* Multiples echoes
* Multiples echoes
* Cystic spaces invading edometrium and myometrium (in case of invasive disease)
* Cystic spaces invading edometrium and myometrium (in case of invasive disease)
| style="background: #F5F5F5; padding: 5px;" |MRI defines the extent of primary lesion, invasion and distant metastasis
| style="background: #F5F5F5; padding: 5px;" |MRI defines the extent of primary lesion, invasion and distant metastasis
Line 497: Line 432:
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Imaging
* Imaging
* Histologic
* Histologic
diagnosis
diagnosis
Line 521: Line 455:
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* Imaging
* Imaging
* Histologic
* Histologic
diagnosis
diagnosis
Line 546: Line 479:
* Not needed once ultrasound
* Not needed once ultrasound
* May show Fetal tissues  
* May show Fetal tissues  
amniotic fluid
| style="background: #F5F5F5; padding: 5px;" |Imaging ([[Transvaginal ultrasound]])
| style="background: #F5F5F5; padding: 5px;" |Imaging ([[Transvaginal ultrasound]])
|-
|-
!Diseases
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Diseases
! colspan="1" rowspan="1" |Bleeding
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Bleeding
!Pelvic Pain/pressure/
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic Pain/pressure/
discomfort
discomfort
!Other
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Other
!Pelvic examination
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pelvic examination
! colspan="1" rowspan="1" |Abdominal examination
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Abdominal examination
!Hb
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Hb
!B-HCG
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |B-HCG
!CA-125
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |CA-125
!Ultrasound
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Ultrasound
!MRI
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |MRI
!Pap Smear
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Pap Smear
!Histopathology
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Histopathology
!Gold standard
! style="background: #4479BA; color: #FFFFFF; text-align: center;" |Gold standard
|-
|-
|}
|}

Revision as of 17:19, 10 February 2019

Endometrial cancer Microchapters

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Overview

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Epidemiology and Demographics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]Roukoz A. Karam, M.D.[3]

Overview

In early stages endometrial cancer must be differentiated from diseases that cause abnormal uterine bleeding and endometrial thickening on ultrasound, such as endometrial hyperplasia, endometrial polyp and submucosal uterine leiomyoma. In advanced stages endometrial cancer must be differentiated from uterine sarcoma and uterine lymphoma.

Differentiating Endometrial Cancer From Other Diseases

  • In early stages endometrial cancer must be differentiated from diseases that cause abnormal uterine bleeding and endometrial thickening on ultrasound, such as endometrial hyperplasia, endometrial polyp and submucosal uterine leiomyoma. In advanced stages endometrial cancer must be differentiated from uterine sarcoma and uterine lymphoma.[1]
Diseases Clinical manifestations Para-clinical findings Gold standard
Symptoms Physical examination
Lab Findings Imaging Pap Smear Histopathology
Bleeding Pelvic Pain/pressure/

discomfort

Other Pelvic examination Abdominal examination Hb B-HCG CA-125 Ultrasound MRI
Endometrial cancer[2][3][4][5]
  • Menorrhagia
  • Metrorrhagia in premenopausal women
  • Postcoital bleeding
  • Intermenstrual bleeding
 ±
  • Enlarged uterus
  • Vaginal bleeding
  • Vaginal discharge
  • Lymphadenopathy
  • Mesenteric nodules(metastasis)
  • Enlarged fixed uterus
 ↓ – +
  • A thickened endometrial lining >4mm
  • Endometrial thickening
  • Lymph node involvement
  • Pelvic metastasis
 Atypical glandular cells Endometrial malignant cells:
  • Low grade Type I
  • High grade Type II
 Histologic diagnosis
Uterine

leiomyosarcoma[6][7][8][9]

  • May have menorrhagia
  • Intermenstrual bleeding
 ±
  • Abdominal pain
  • Urinary symptoms
  • Abdominal distension
  • Asymptomatic
 ↓ – +
  • Uterine mass
  • Lymph node metastases
 Shows details of uterine mass boundaries, extent and spread Negative Epithiloid shaped smooth muscle cells showing:

Two variants of leiomyosarcoma:

Histologic diagnosis
Diseases Bleeding Pelvic Pain/pressure/

discomfort

Other Pelvic examination Abdominal examination Hb B-HCG CA-125 Ultrasound MRI Pap Smear Histopathology Gold standard
Uterine leiomyoma[10][11][12]
  • May have menorrhagia
  • May have intermenstrual bleeding
 +
  • Asymptomatic
  • Infertility
  • Obstetric complications
  • Dysmenorrhea (most common symptoms)
  • Obstructive symptoms(due to urinary bladder and bowel compression)
  • Dyspareunia
  • Torsion or degeneration
  • Enlarged mobile uterus
  • Irregular contour
  • Usually normal
  • Large fibroid uteri may cause abdominal distention
 ↓ or Nl – – US shows:
  • Hypoechoic, well-circumscribed round masses

US determines location of fibroid:

  • Determines:
    • Size
    • Location
    • Numbers
  • Shows "popcorn" calcification in the fibroid (degeneration)
  • Differentiaites between leiomyomas, adenomyosisand adenomyomas
 Normal Normal appearing bundle of epithiloid shape smooth muscle cells with normal mitotic index Imaging and histologic analysis
Uterine carcinosarcomas (Malignant mixed mullerian tumour (MMMT) of the uterus)[13][14][15][16]
  • May have menorrhagia
  • May have intermenstrual bleeding
 ±
  • Classical triad:
    • Pain
    • Bleeding
    • Rapidly enlarging uterus
  • Enlarged uterus
  • pelvic mass
  • Mass protruding through the cervical os
  • Involvement of the cervix
  • Normal
  • May show distention if tumor size is large
 ↓ – +
  • Enlarged uterine cavity
  • Hyperechoic mass in uterus and cervix
 Heterogenous bulky polypoid mass with intense enhancement Biphasic (carcinoma/sarcoma combination) and contains:
  • High grade carcinomatous (epithelial) contents
  • Stromal sarcomatous (connective tissue)
 Histologic diagnosis
Cervical cancer with uterine invasion[17][18]
  • Menorrhagia
  • Intermenstrual bleeding
  • Postcoital bleeding
  • Vaginal passage of bleeding
 ±
  • Copious malodorous vaginal discharge
  • Pressure-related bowel and bladder symptoms
  • Hematuria
  • Enlarged uterus
  • Concomitant cervical lesions
  • Abdominal distention
 ↓ – ± For cervical cancer diagnoses, imaging is not usually done rather it is used to see the metastasis. Ultrasound may be used to see tumor size, extent and parametrial invasion. To evaluate tumor size and local extent and for its staging.

Pap test is done simultaneously with HPV testing, if cervical cancer is suspected. Abnormal pap test may show two type of abnormal cells:

  • Squamous cell carcinoma
    • Low-grade squamous intraepithelial lesions (LSILs)
    • High-grade squamous intraepithelial lesions (HSILs)
  • Adenocarcinoma
    • Atypical glandular cells (AGC)
    • Endocervical adenocarcinoma in situ (AIS)
 If pap test shows abnormal results. Colposcopy and biopsy is done. Histologic types are Histologic diagnosis
Diseases Bleeding Pelvic Pain/pressure/

discomfort

Other Pelvic examination Abdominal examination Hb B-HCG CA-125 Ultrasound MRI Pap Smear Histopathology Gold standard
Metastasis
  • Menorrhagia
  • Intermenstrual bleeding
 ±
  • Asymptomatic
  • Obstetric complications
  • Dysmenorrhea (most common symptoms)
  • Obstructive symptoms (due to urinary bladder and bowel compression)
  • Dyspareunia
  • Enlarged uterus
  • Abdominal distention
 ↓ – –
  • Enlarged uterine cavity
  • Hyperechoic mass in uterus and cervix
 Shows involvement of uterus, lymph nodes, parmetrial area and surrounding area. Is normal or may show malignant metastatic cells. Although biopsy of the metastatic lesions to the uterus is not recommended however, it shows the malignant cells of the primary site. Biopsy and histology of the primary site of the tumor
Endometrial

polyp[19][20]

  • Menorrhagia
  • Intermenstrual bleeding
  • Postmenopausal bleeding
 –
  • Asymptomatic
  • Endometrial polyp prolapses (will be visible on speculum examination protruding through cervical os)
  • Normal sized uterus with smooth surface
  • Normal
 ↓ – + or Nl Incidentally on pelvic ultrasound (most common) MRI will show polyp size and dimension in detail but it is usually is not required for its diagnoses. Normal Biopsy and histopathology analysis will show localized hyperplastic growth of endometrial glands and stroma around a vessel.
  • Imaging
  • Histologic evaluation
Endometrial

hyperpalsia[21][22][23][24]

  • Menorrhagia
  • Intermenstrual bleeding
  • Postmenopausal bleeding
 –
  • Asymptomatic
  • Normal sized uterus with smooth surface
  • Normal
 ↓ – +
  • Determines endometrial thickness
  • Rules out other abnormalities
 Thick endometrial lining Abnormal glandular or endometrial cells on pap smear
  • Endometrial sampling is used (gold standard) for the diagnosis of endometrial hyperplasia.
  • Biopsy and histology may show two types:
    • Non-neoplastic changes:
      • Disordered endometrial growth
      • Benign hyperplasia
      • Simple hyperplasia
      • Complex hyperplasias without atypia
  • Precancerous changes:
    • Endometrial intraepithelial neoplasms
    • Atypical complex hyperplasia

Histologic diagnosis

Uterine

adenomyoma[25][26][27]

- ±
  • Diffusely enlarged tender boggy uterus with smooth surface
  • Uterus may develop masses
  • Normal
 ↓ – +
  • Snow storm appearance in diffuse adenomyosis
  • Shows a uterine mass in case of adenomas
 Identifies diffuse or focal adenomyosis from leiomyoma Mostly normal may show glandular cells in cervical cytology Endometrial glands in myometrium of uterus
  • Imaging
  • Histologic

diagnosis

Diseases Bleeding Pelvic Pain/pressure/

discomfort

Other Pelvic examination Abdominal examination Hb B-HCG CA-125 Ultrasound MRI Pap Smear Histopathology Gold standard
Hematometra (blood within the uterine cavity)

[28][29]

- +
  • Acute pain abdomen
  • Cramping in pelvis
  • Cyclic pain
  • Dysmenorrhea
  • Amenorrhea
  • Hypotension
  • Vasovagal syncopy
  • Firm and enlarged uterus
  • Adenaxal tenderness
  • Pelvic examination may be restricted by pain
  • Normal
 ↓ – – Echogenic fluid in the uterine cavity occluding cervical os MRI is not required for the diagnoses Normal Biopsy is not required for the diagnoses Ultrasound
Gestational trophoblastic disease[30][31]
  • May have menorrhagia
  • May have intermenstrual bleeding
 + Metastatic symptoms in case of cancer:
  • Pulmonary symptoms
    • Dyspnea
    • Chest pain
    • Cough
    • Hemoptysis
  • Vaginal metastases
    • Vaginal bleeding
    • Purulent vaginal discharge
  • Central nervous system metastases
    • Asymptomatic
    • Neurologic signs
  • Irregularly sized boggy enlarged uterus
  • Adnexal fullness
  • Abdominal distention
 ↓ ± +
  • US shows dilated grape like structures
  • Diffuse hydropic swelling
  • Multiples echoes
  • Cystic spaces invading edometrium and myometrium (in case of invasive disease)
 MRI defines the extent of primary lesion, invasion and distant metastasis Pap smear shows trophoblasric cells Biopsy and histologic analysis confirms the diagnoses depending on the type of lesion benign or malignant it may sow dilated grape like villous structures or invasive malignant lesions
  • Imaging
  • Histologic

diagnosis

Incomplete abortion
  • Intermenstrual bleeding
  • Vaginal bleeding
 +
  • Abdominal pain/ cramps
  • Enlarges uterus
  • Abdominal distention
 N/↓ ± +↓ Uterus shows fetus with absent cardiac activity in lower part of uterus MRI is not required for the diagnoses Pap smear is not done for the diagnoses Suction biopsy and histology shows fetal and placental tissues
  • Imaging
  • Histologic

diagnosis

Pregnancy
  • Absent menstrual cycle
  • May have intermenstrual bleeding
 +
  • Nausea
  • Fatigue
  • Enlarged gravid uterus
  • Abdominal distention
 – + – Fetus inside uterine cavity Not needed once ultrasound determines pregnancy Normal or may show cervical cells
  • Not needed once ultrasound
  • May show Fetal tissues
 Imaging (Transvaginal ultrasound)
Diseases Bleeding Pelvic Pain/pressure/

discomfort

Other Pelvic examination Abdominal examination Hb B-HCG CA-125 Ultrasound MRI Pap Smear Histopathology Gold standard

References

  1. ↑ Hippisley-Cox J, Coupland C (2011). "Identifying women with suspected ovarian cancer in primary care: derivation and validation of algorithm". BMJ. 344: d8009. doi:10.1136/bmj.d8009. PMC 3251328. PMID 22217630.
  2. ↑ "ACOG practice bulletin, clinical management guidelines for obstetrician-gynecologists, number 65, August 2005: management of endometrial cancer". Obstet Gynecol. 106 (2): 413–25. August 2005. PMID 16055605.
  3. ↑ Boruta DM, Gehrig PA, Fader AN, Olawaiye AB (October 2009). "Management of women with uterine papillary serous cancer: a Society of Gynecologic Oncology (SGO) review". Gynecol. Oncol. 115 (1): 142–153. doi:10.1016/j.ygyno.2009.06.011. PMID 19592079.
  4. ↑ Bokhman JV (February 1983). "Two pathogenetic types of endometrial carcinoma". Gynecol. Oncol. 15 (1): 10–7. PMID 6822361.
  5. ↑ Felix AS, Weissfeld JL, Stone RA, Bowser R, Chivukula M, Edwards RP, Linkov F (November 2010). "Factors associated with Type I and Type II endometrial cancer". Cancer Causes Control. 21 (11): 1851–6. doi:10.1007/s10552-010-9612-8. PMC 2962676. PMID 20628804.
  6. ↑ Nordal RR, Thoresen SO (May 1997). "Uterine sarcomas in Norway 1956-1992: incidence, survival and mortality". Eur. J. Cancer. 33 (6): 907–11. PMID 9291814.
  7. ↑ Goto A, Takeuchi S, Sugimura K, Maruo T (2002). "Usefulness of Gd-DTPA contrast-enhanced dynamic MRI and serum determination of LDH and its isozymes in the differential diagnosis of leiomyosarcoma from degenerated leiomyoma of the uterus". Int. J. Gynecol. Cancer. 12 (4): 354–61. PMID 12144683.
  8. ↑ Bell SW, Kempson RL, Hendrickson MR (June 1994). "Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases". Am. J. Surg. Pathol. 18 (6): 535–58. PMID 8179071.
  9. ↑ Karpathiou G, Sivridis E, Giatromanolaki A (2010). "Myxoid leiomyosarcoma of the uterus: a diagnostic challenge". Eur. J. Gynaecol. Oncol. 31 (4): 446–8. PMID 20882892.
  10. ↑ Stewart EA (April 2015). "Clinical practice. Uterine fibroids". N. Engl. J. Med. 372 (17): 1646–55. doi:10.1056/NEJMcp1411029. PMID 25901428.
  11. ↑ Dueholm M, Lundorf E, Hansen ES, Ledertoug S, Olesen F (March 2002). "Accuracy of magnetic resonance imaging and transvaginal ultrasonography in the diagnosis, mapping, and measurement of uterine myomas". Am. J. Obstet. Gynecol. 186 (3): 409–15. PMID 11904599.
  12. ↑ Omary RA, Vasireddy S, Chrisman HB, Ryu RK, Pereles FS, Carr JC, Resnick SA, Nemcek AA, Vogelzang RL (November 2002). "The effect of pelvic MR imaging on the diagnosis and treatment of women with presumed symptomatic uterine fibroids". J Vasc Interv Radiol. 13 (11): 1149–53. PMID 12427815.
  13. ↑ Chaffer CL, San Juan BP, Lim E, Weinberg RA (December 2016). "EMT, cell plasticity and metastasis". Cancer Metastasis Rev. 35 (4): 645–654. doi:10.1007/s10555-016-9648-7. PMID 27878502.
  14. ↑ Zhao S, Bellone S, Lopez S, Thakral D, Schwab C, English DP, Black J, Cocco E, Choi J, Zammataro L, Predolini F, Bonazzoli E, Bi M, Buza N, Hui P, Wong S, Abu-Khalaf M, Ravaggi A, Bignotti E, Bandiera E, Romani C, Todeschini P, Tassi R, Zanotti L, Odicino F, Pecorelli S, Donzelli C, Ardighieri L, Facchetti F, Falchetti M, Silasi DA, Ratner E, Azodi M, Schwartz PE, Mane S, Angioli R, Terranova C, Quick CM, Edraki B, Bilgüvar K, Lee M, Choi M, Stiegler AL, Boggon TJ, Schlessinger J, Lifton RP, Santin AD (October 2016). "Mutational landscape of uterine and ovarian carcinosarcomas implicates histone genes in epithelial-mesenchymal transition". Proc. Natl. Acad. Sci. U.S.A. 113 (43): 12238–12243. doi:10.1073/pnas.1614120113. PMC 5087050. PMID 27791010.
  15. ↑ Callister M, Ramondetta LM, Jhingran A, Burke TW, Eifel PJ (March 2004). "Malignant mixed Müllerian tumors of the uterus: analysis of patterns of failure, prognostic factors, and treatment outcome". Int. J. Radiat. Oncol. Biol. Phys. 58 (3): 786–96. doi:10.1016/S0360-3016(03)01561-X. PMID 14967435.
  16. ↑ Teo SY, Babagbemi KT, Peters HE, Mortele KJ (July 2008). "Primary malignant mixed mullerian tumor of the uterus: findings on sonography, CT, and gadolinium-enhanced MRI". AJR Am J Roentgenol. 191 (1): 278–83. doi:10.2214/AJR.07.3281. PMID 18562759.
  17. ↑ "Pap and HPV Testing - National Cancer Institute".
  18. ↑ Benedet JL, Bender H, Jones H, Ngan HY, Pecorelli S (August 2000). "FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers. FIGO Committee on Gynecologic Oncology". Int J Gynaecol Obstet. 70 (2): 209–62. PMID 11041682.
  19. ↑ Kim KR, Peng R, Ro JY, Robboy SJ (August 2004). "A diagnostically useful histopathologic feature of endometrial polyp: the long axis of endometrial glands arranged parallel to surface epithelium". Am. J. Surg. Pathol. 28 (8): 1057–62. PMID 15252313.
  20. ↑ Salim S, Won H, Nesbitt-Hawes E, Campbell N, Abbott J (2011). "Diagnosis and management of endometrial polyps: a critical review of the literature". J Minim Invasive Gynecol. 18 (5): 569–81. doi:10.1016/j.jmig.2011.05.018. PMID 21783430.
  21. ↑ Emons G, Beckmann MW, Schmidt D, Mallmann P (February 2015). "New WHO Classification of Endometrial Hyperplasias". Geburtshilfe Frauenheilkd. 75 (2): 135–136. doi:10.1055/s-0034-1396256. PMC 4361167. PMID 25797956.
  22. ↑ Wright TC, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D (October 2007). "2006 consensus guidelines for the management of women with abnormal cervical screening tests". J Low Genit Tract Dis. 11 (4): 201–22. doi:10.1097/LGT.0b013e3181585870. PMID 17917566.
  23. ↑ Espindola D, Kennedy KA, Fischer EG (December 2007). "Management of abnormal uterine bleeding and the pathology of endometrial hyperplasia". Obstet. Gynecol. Clin. North Am. 34 (4): 717–37, ix. doi:10.1016/j.ogc.2007.09.001. PMID 18061866.
  24. ↑ Montgomery BE, Daum GS, Dunton CJ (May 2004). "Endometrial hyperplasia: a review". Obstet Gynecol Surv. 59 (5): 368–78. PMID 15097798.
  25. ↑ McElin TW, Bird CC (1974). "Adenomyosis of the uterus". Obstet Gynecol Annu. 3: 425–41. PMID 4608783.
  26. ↑ Maheshwari A, Gurunath S, Fatima F, Bhattacharya S (July 2012). "Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes". Hum. Reprod. Update. 18 (4): 374–92. doi:10.1093/humupd/dms006. PMID 22442261.
  27. ↑ Byun JY, Kim SE, Choi BG, Ko GY, Jung SE, Choi KH (October 1999). "Diffuse and focal adenomyosis: MR imaging findings". Radiographics. 19 Spec No: S161–70. doi:10.1148/radiographics.19.suppl_1.g99oc03s161. PMID 10517452.
  28. ↑ McCausland AM, McCausland VM (2007). "Long-term complications of endometrial ablation: cause, diagnosis, treatment, and prevention". J Minim Invasive Gynecol. 14 (4): 399–406. doi:10.1016/j.jmig.2007.04.004. PMID 17630156.
  29. ↑ U Nayak A, Swarup A, G S J, N S (April 2010). "Hematometra and acute abdomen". J Emerg Trauma Shock. 3 (2): 191–2. doi:10.4103/0974-2700.62117. PMC 2884455. PMID 20606801. Vancouver style error: name (help)
  30. ↑ Bakri YN, Berkowitz RS, Khan J, Goldstein DP, von Sinner W, Jabbar FA (March 1994). "Pulmonary metastases of gestational trophoblastic tumor. Risk factors for early respiratory failure". J Reprod Med. 39 (3): 175–8. PMID 8035373.
  31. ↑ Lurain JR (December 2010). "Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole". Am. J. Obstet. Gynecol. 203 (6): 531–9. doi:10.1016/j.ajog.2010.06.073. PMID 20728069.
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