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=== Epithelial Ovarian Cancer Classification Based on Clinicopathologic and Molecular Evidence === | === Epithelial Ovarian Cancer Classification Based on Clinicopathologic and Molecular Evidence === | ||
* Recent advances in histopathology and a better understanding of clinicopathologic characteristics have led to a classification system that correlates histology and clinical characteristics | * Recent advances in histopathology and a better understanding of clinicopathologic characteristics have led to a classification system that correlates histology and clinical characteristics. | ||
* This classification subdivides malignant ovarian tumors in two types. | * This classification subdivides malignant ovarian tumors in two types. | ||
* '''Type I''' tumors generally arise from endometriosis or fallopian tubal related serous epithelium. They exhibit less aggressive clinical course and a different genetic profile relative to '''Type II'''. | * '''Type I''' tumors generally arise from endometriosis or fallopian tubal related serous epithelium. They exhibit less aggressive clinical course and a different genetic profile relative to '''Type II'''.<ref name="pmid27983698">{{cite journal |vauthors=Rojas V, Hirshfield KM, Ganesan S, Rodriguez-Rodriguez L |title=Molecular Characterization of Epithelial Ovarian Cancer: Implications for Diagnosis and Treatment |journal=Int J Mol Sci |volume=17 |issue=12 |pages= |date=December 2016 |pmid=27983698 |pmc=5187913 |doi=10.3390/ijms17122113 |url=}}</ref> | ||
* '''Type II''' tumors generally arise from fallopian tubal epithelium. They exhibit more aggressive clinical course and a different genetic profile relative to '''Type I'''. | * '''Type II''' tumors generally arise from fallopian tubal epithelium. They exhibit more aggressive clinical course and a different genetic profile relative to '''Type I'''.<ref name="pmid27983698">{{cite journal |vauthors=Rojas V, Hirshfield KM, Ganesan S, Rodriguez-Rodriguez L |title=Molecular Characterization of Epithelial Ovarian Cancer: Implications for Diagnosis and Treatment |journal=Int J Mol Sci |volume=17 |issue=12 |pages= |date=December 2016 |pmid=27983698 |pmc=5187913 |doi=10.3390/ijms17122113 |url=}}</ref> | ||
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Revision as of 19:27, 13 February 2019
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Epithelial ovarian tumors Microchapters |
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Differentiating Epithelial Ovarian Tumors from other Diseases |
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Epithelial ovarian tumors classification On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Hannan Javed, M.D.[2]
Overview
Classification
General Classification
- Epithelial ovarian tumors can broadly be classified on the bases of histopathology and clinical behavior as:[1][2][3][4][5][6]
- Benign
- Borderline
- Malignant tumors
- Table below provides a summary of this classification:
| Epithelial ovarian tumors | ||
|---|---|---|
| Benign | Borderline | Malignant |
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WHO Classification of Ovarian Epithelial Tumors
- WHO classifies epithelial ovarian tumors on the basis of histology as follows:[2][3][4][5][6]
- Serous tumors:
- Benign (cystadenoma)
- Borderline tumors (serous borderline tumor)
- Malignant (serous adenocarcinoma)
- Mucinous tumors:
- Benign (cystadenoma)
- Borderline tumors (mucinous borderline tumor)
- Malignant (mucinous adenocarcinoma)
- Endometrioid tumors:
- Benign (cystadenoma)
- Borderline tumors (endometrioid borderline tumor)
- Malignant (endometrioid adenocarcinoma)
- Clear cell tumors:
- Benign
- Borderline tumors
- Malignant (clear cell adenocarcinoma)
- Transitional cell tumors:
- Brenner tumor
- Brenner tumor of borderline malignancy
- Malignant Brenner tumor
- Transitional cell carcinoma (non-Brenner type)
- Epithelial-stromal:
- Adenosarcoma
- Carcinosarcoma (formerly mixed Müllerian tumors)
- Serous tumors:
| Ovarian epithelial tumors | |||||
|---|---|---|---|---|---|
| Serous tumors | Mucinous tumors | Endometrioid tumors | Clear cell tumors | Transitional cell tumors | Epithelial-stromal |
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=== International Agency for Research on Cancer Histologic Groups of Ovarian Tumors ===[4][5]
| Ovarian tumors |
|---|
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Epithelial Ovarian Cancer Classification Based on Clinicopathologic and Molecular Evidence
- Recent advances in histopathology and a better understanding of clinicopathologic characteristics have led to a classification system that correlates histology and clinical characteristics.
- This classification subdivides malignant ovarian tumors in two types.
- Type I tumors generally arise from endometriosis or fallopian tubal related serous epithelium. They exhibit less aggressive clinical course and a different genetic profile relative to Type II.[1]
- Type II tumors generally arise from fallopian tubal epithelium. They exhibit more aggressive clinical course and a different genetic profile relative to Type I.[1]
| Epithelial Ovarian Cancer | |
|---|---|
| Type I | Type II |
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WHO Classification of Ovarian Tumors
| Ovarian Cancer | |||
|---|---|---|---|
| Epithelial | Sex-cord stromal | Germ cell | Others |
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References
- ↑ 1.0 1.1 1.2 Rojas V, Hirshfield KM, Ganesan S, Rodriguez-Rodriguez L (December 2016). "Molecular Characterization of Epithelial Ovarian Cancer: Implications for Diagnosis and Treatment". Int J Mol Sci. 17 (12). doi:10.3390/ijms17122113. PMC 5187913. PMID 27983698.
- ↑ 2.0 2.1 Horta M, Cunha TM (2015). "Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists". Diagn Interv Radiol. 21 (4): 277–86. doi:10.5152/dir.2015.34414. PMC 4498422. PMID 26054417.
- ↑ 3.0 3.1 McCluggage WG (August 2011). "Morphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesis". Pathology. 43 (5): 420–32. doi:10.1097/PAT.0b013e328348a6e7. PMID 21716157.
- ↑ 4.0 4.1 4.2 Meinhold-Heerlein I, Fotopoulou C, Harter P, Kurzeder C, Mustea A, Wimberger P, Hauptmann S, Sehouli J (April 2016). "The new WHO classification of ovarian, fallopian tube, and primary peritoneal cancer and its clinical implications". Arch. Gynecol. Obstet. 293 (4): 695–700. doi:10.1007/s00404-016-4035-8. PMID 26894303.
- ↑ 5.0 5.1 5.2 "onlinelibrary.wiley.com".
- ↑ 6.0 6.1 Kurman RJ, Shih I (March 2010). "The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory". Am. J. Surg. Pathol. 34 (3): 433–43. doi:10.1097/PAS.0b013e3181cf3d79. PMC 2841791. PMID 20154587. Vancouver style error: initials (help)