Paget's disease of the breast history and symptoms: Difference between revisions
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===Symptoms=== | ===Symptoms=== | ||
Symptoms of Paget's disease of the breast usually occur in one breast but can present bilaterally. Some patients have two or more or a combination of the below symptoms at presentation. They can also be asymptomatic. Symptoms of Paget's disease of the breast include: <ref name="pmid16933329">{{cite journal |vauthors=Chen CY, Sun LM, Anderson BO |title=Paget disease of the breast: changing patterns of incidence, clinical presentation, and treatment in the U.S |journal=Cancer |volume=107 |issue=7 |pages=1448–58 |date=October 2006 |pmid=16933329 |doi=10.1002/cncr.22137 |url=}}</ref><ref name="pmid17447970">{{cite journal |vauthors=Kanitakis J |title=Mammary and extramammary Paget's disease |journal=J Eur Acad Dermatol Venereol |volume=21 |issue=5 |pages=581–90 |date=May 2007 |pmid=17447970 |doi=10.1111/j.1468-3083.2007.02154.x |url=}}</ref><ref name="pmid4318756">{{cite journal |vauthors=Ashikari R, Park K, Huvos AG, Urban JA |title=Paget's disease of the breast |journal=Cancer |volume=26 |issue=3 |pages=680–5 |date=September 1970 |pmid=4318756 |doi= |url=}}</ref><ref name="pmid27178684">{{cite journal |vauthors=Tan AR |title=Cutaneous manifestations of breast cancer |journal=Semin. Oncol. |volume=43 |issue=3 |pages=331–4 |date=June 2016 |pmid=27178684 |doi=10.1053/j.seminoncol.2016.02.030 |url=}}</ref><ref name="pmid16174159">{{cite journal |vauthors=Franceschini G, Masetti R, D'Ugo D, Palumbo F, D'Alba P, Mulè A, Costantini M, Belli P, Picciocchi A |title=Synchronous bilateral Paget's disease of the nipple associated with bilateral breast carcinoma |journal=Breast J |volume=11 |issue=5 |pages=355–6 |date=2005 |pmid=16174159 |doi=10.1111/j.1075-122X.2005.21722.x |url=}}</ref> | Symptoms of Paget's disease of the breast usually occur in one breast but can present bilaterally. Some patients have two or more or a combination of the below symptoms at presentation. They can also be asymptomatic. Symptoms of Paget's disease of the breast include: <ref name="pmid16933329">{{cite journal |vauthors=Chen CY, Sun LM, Anderson BO |title=Paget disease of the breast: changing patterns of incidence, clinical presentation, and treatment in the U.S |journal=Cancer |volume=107 |issue=7 |pages=1448–58 |date=October 2006 |pmid=16933329 |doi=10.1002/cncr.22137 |url=}}</ref><ref name="pmid17447970">{{cite journal |vauthors=Kanitakis J |title=Mammary and extramammary Paget's disease |journal=J Eur Acad Dermatol Venereol |volume=21 |issue=5 |pages=581–90 |date=May 2007 |pmid=17447970 |doi=10.1111/j.1468-3083.2007.02154.x |url=}}</ref><ref name="pmid4318756">{{cite journal |vauthors=Ashikari R, Park K, Huvos AG, Urban JA |title=Paget's disease of the breast |journal=Cancer |volume=26 |issue=3 |pages=680–5 |date=September 1970 |pmid=4318756 |doi= |url=}}</ref><ref name="pmid27178684">{{cite journal |vauthors=Tan AR |title=Cutaneous manifestations of breast cancer |journal=Semin. Oncol. |volume=43 |issue=3 |pages=331–4 |date=June 2016 |pmid=27178684 |doi=10.1053/j.seminoncol.2016.02.030 |url=}}</ref><ref name="pmid16174159">{{cite journal |vauthors=Franceschini G, Masetti R, D'Ugo D, Palumbo F, D'Alba P, Mulè A, Costantini M, Belli P, Picciocchi A |title=Synchronous bilateral Paget's disease of the nipple associated with bilateral breast carcinoma |journal=Breast J |volume=11 |issue=5 |pages=355–6 |date=2005 |pmid=16174159 |doi=10.1111/j.1075-122X.2005.21722.x |url=}}</ref><ref>{{cite book | last = Rosen | first = Paul | title = Rosen's breast pathology | publisher = Wolters Kluwer Health/Lippincott Williams & Wilkins | location = Philadelphia | year = 2014 | isbn = 9781451176537 }}</ref> | ||
*[[Pruritis]] or [[erythema]] of the nipple and/or areola. | *[[Pruritis]] or [[erythema]] of the nipple and/or areola. | ||
*Flaking, crusting, or thickening of the [[skin]] that begins at the nipple and spreads to the areola with irregular borders. | *Flaking, crusting, or thickening of the [[skin]] that begins at the nipple and spreads to the areola with irregular borders but can spread to surrounding skin. | ||
*Erosion or [[ulceration]] of the nipple. | *Erosion or [[ulceration]] of the nipple. | ||
*A flattened, inverted or [[retracted nipple]]. | *A flattened, inverted or [[retracted nipple]]. | ||
*Bloody or serosanguinous [[discharge]] from the nipple. | *Bloody or serosanguinous [[discharge]] from the nipple. | ||
*A palpable breast mass is present in 50% of patients. | *A palpable breast mass is present in 50% of patients. | ||
*Advanced lesions present as a round, ovoid or polycylic eczema-like plaque with a pink or red discoloration. | |||
*Lesion is sharply demarcated from the adjacent normal skin. | |||
==References== | ==References== | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
Symptoms of Paget's disease of the breast include itching, redness, thickened skin, and ulceration of the nipple.
History and symptoms
History
A detailed history documenting the length of time the lesion along with any associated symptoms should be taken.By clinical history, the cancer risk can be evaluated:[1]
- Age at menarche
- Menopausal status
- Number of pregnancies
- Previous history of radiation
- History of oral contraceptives or hormone replacement therapy
- Past history of breast cancer and age at time of diagnosis
- Familial history of breast cancer or ovarian cancer in first-degree relatives
- Other associated breast disease or possible biopsies
Symptoms
Symptoms of Paget's disease of the breast usually occur in one breast but can present bilaterally. Some patients have two or more or a combination of the below symptoms at presentation. They can also be asymptomatic. Symptoms of Paget's disease of the breast include: [2][3][4][5][6][7]
- Pruritis or erythema of the nipple and/or areola.
- Flaking, crusting, or thickening of the skin that begins at the nipple and spreads to the areola with irregular borders but can spread to surrounding skin.
- Erosion or ulceration of the nipple.
- A flattened, inverted or retracted nipple.
- Bloody or serosanguinous discharge from the nipple.
- A palpable breast mass is present in 50% of patients.
- Advanced lesions present as a round, ovoid or polycylic eczema-like plaque with a pink or red discoloration.
- Lesion is sharply demarcated from the adjacent normal skin.
References
- ↑ Shah R, Rosso K, Nathanson SD (2014). "Pathogenesis, prevention, diagnosis and treatment of breast cancer". World J Clin Oncol. 5 (3): 283–98. doi:10.5306/wjco.v5.i3.283. PMC 4127601. PMID 25114845.
- ↑ Chen CY, Sun LM, Anderson BO (October 2006). "Paget disease of the breast: changing patterns of incidence, clinical presentation, and treatment in the U.S". Cancer. 107 (7): 1448–58. doi:10.1002/cncr.22137. PMID 16933329.
- ↑ Kanitakis J (May 2007). "Mammary and extramammary Paget's disease". J Eur Acad Dermatol Venereol. 21 (5): 581–90. doi:10.1111/j.1468-3083.2007.02154.x. PMID 17447970.
- ↑ Ashikari R, Park K, Huvos AG, Urban JA (September 1970). "Paget's disease of the breast". Cancer. 26 (3): 680–5. PMID 4318756.
- ↑ Tan AR (June 2016). "Cutaneous manifestations of breast cancer". Semin. Oncol. 43 (3): 331–4. doi:10.1053/j.seminoncol.2016.02.030. PMID 27178684.
- ↑ Franceschini G, Masetti R, D'Ugo D, Palumbo F, D'Alba P, Mulè A, Costantini M, Belli P, Picciocchi A (2005). "Synchronous bilateral Paget's disease of the nipple associated with bilateral breast carcinoma". Breast J. 11 (5): 355–6. doi:10.1111/j.1075-122X.2005.21722.x. PMID 16174159.
- ↑ Rosen, Paul (2014). Rosen's breast pathology. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins. ISBN 9781451176537.