Cervical cancer causes: Difference between revisions
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==Causes== | ==Causes== | ||
* [[Human papillomavirus]] is main cause of cervical cancer, only high-risk [[HPV]] types are the ones can affect squamous [[epithelium]] of cervix and cause cancer. | * [[Human papillomavirus]] is main cause of cervical cancer, only high-risk [[HPV]] types are the ones can affect squamous [[epithelium]] of [[cervix]] and cause cancer. | ||
* [[HPV]] is a small, nonenveloped [[DNA]] virus, 55 nm in diameter, transmits primarily by skin to skin contact. <ref name="pmid12525422">{{cite journal |vauthors=Burd EM |title=Human papillomavirus and cervical cancer |journal=Clin. Microbiol. Rev. |volume=16 |issue=1 |pages=1–17 |date=January 2003 |pmid=12525422 |doi= |url=}}</ref> | * [[HPV]] is a small, nonenveloped [[DNA]] virus, 55 nm in diameter, transmits primarily by skin to skin contact. <ref name="pmid12525422">{{cite journal |vauthors=Burd EM |title=Human papillomavirus and cervical cancer |journal=Clin. Microbiol. Rev. |volume=16 |issue=1 |pages=1–17 |date=January 2003 |pmid=12525422 |doi= |url=}}</ref> | ||
* High risk strains include types 16, 18, 31, 33, 34, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, and 70. | * High risk strains include types 16, 18, 31, 33, 34, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, and 70. | ||
* [[HPV]] [[oncogenes]] interfere with cell cycle control and causes abnormal growth of squamous cells in epithelium of cervix. | * [[HPV]] [[oncogenes]] interfere with [[cell cycle]] control and causes abnormal growth of [[squamous cells]] in [[epithelium]] of [[cervix]]. | ||
* The assosiciation between [[HPV]] infection and [[glandular]] type of cervical neoplasia is less strong than that of squamous carcinoma of [[cervix]]. | * The assosiciation between [[HPV]] infection and [[glandular]] type of cervical [[neoplasia]] is less strong than that of squamous carcinoma of [[cervix]]. | ||
==References== | ==References== | ||
Revision as of 14:38, 20 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Nima Nasiri, M.D.[2]Monalisa Dmello, M.B,B.S., M.D. [3]
Overview
Cervical cancer is caused by an infection with Human papillomavirus, which is transmitted by skin to skin contact and sexually. Only high risk strains of HPV are causing cervical cancer, having multiple sexual partner is a risk factor for infecting with HPV.
Causes
- Human papillomavirus is main cause of cervical cancer, only high-risk HPV types are the ones can affect squamous epithelium of cervix and cause cancer.
- HPV is a small, nonenveloped DNA virus, 55 nm in diameter, transmits primarily by skin to skin contact. [1]
- High risk strains include types 16, 18, 31, 33, 34, 35, 39, 45, 51, 52, 56, 58, 59, 66, 68, and 70.
- HPV oncogenes interfere with cell cycle control and causes abnormal growth of squamous cells in epithelium of cervix.
- The assosiciation between HPV infection and glandular type of cervical neoplasia is less strong than that of squamous carcinoma of cervix.