Paget's disease of the breast causes: Difference between revisions
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{{CMG}}; {{AE}} {{PSK}} | {{CMG}}; {{AE}} {{PSK}} | ||
==Overview== | ==Overview== | ||
The cause of Paget's disease of the breast has not been identified. | *The cause of Paget's disease of the breast has not been identified. | ||
There are two widely excepted hypothesis: | There are two widely excepted hypothesis: | ||
*The most widely accepted theory is that the disease results from an underlying intra-ductal breast carcinoma. The cancer cells are hypothesized to travel through lactiferous ducts to the nipple and its surrounding skin. | :*The most widely accepted theory is that the disease results from an underlying intra-ductal breast carcinoma. The cancer cells are hypothesized to travel through lactiferous ducts to the nipple and its surrounding skin. | ||
*Another theory is that the disease can develop independently in the nipple as an in-situ carcinoma. | :*Another theory is that the disease can develop independently in the nipple as an in-situ carcinoma. | ||
. | |||
*Mutations predisposing patients to Paget's disease of the breast have not yet been described in the literature. | |||
*It is currently hypothesized that intraepidermal cells of Paget's disease may be intrinsically genetically different than those of the underlying breast carcinoma. | |||
*This has been seen by specific chromosomal alterations identified by loss of heterozygosity and mitochondrial DNA displacement loop sequence analysis. | |||
==Causes== | ==Causes== |
Revision as of 17:31, 6 March 2019
Paget's disease of the breast Microchapters |
Differentiating Paget's disease of the breast from other Diseases |
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Diagnosis |
Treatment |
Case Studies |
Paget's disease of the breast causes On the Web |
American Roentgen Ray Society Images of Paget's disease of the breast causes |
Directions to Hospitals Treating Paget's disease of the breast |
Risk calculators and risk factors for Paget's disease of the breast causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2]
Overview
- The cause of Paget's disease of the breast has not been identified.
There are two widely excepted hypothesis:
- The most widely accepted theory is that the disease results from an underlying intra-ductal breast carcinoma. The cancer cells are hypothesized to travel through lactiferous ducts to the nipple and its surrounding skin.
- Another theory is that the disease can develop independently in the nipple as an in-situ carcinoma.
.
- Mutations predisposing patients to Paget's disease of the breast have not yet been described in the literature.
- It is currently hypothesized that intraepidermal cells of Paget's disease may be intrinsically genetically different than those of the underlying breast carcinoma.
- This has been seen by specific chromosomal alterations identified by loss of heterozygosity and mitochondrial DNA displacement loop sequence analysis.
Causes
The cause of Paget's disease of the breast has not been identified.