Sexcord/ stromal ovarian tumors risk factors: Difference between revisions
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==Risk Factors== | ==Risk Factors== | ||
There is very little data regarding the risk factors of sexcord-stromal ovarian tumors, however given below are some of the risk factors for the development of sexcord-stromal ovarian tumors: | |||
<ref name="pmid24530563">{{cite journal |vauthors=Sieh W, Sundquist K, Sundquist J, Winkleby MA, Crump C |title=Intrauterine factors and risk of nonepithelial ovarian cancers |journal=Gynecol. Oncol. |volume=133 |issue=2 |pages=293–7 |date=May 2014 |pmid=24530563 |pmc=4006291 |doi=10.1016/j.ygyno.2014.02.007 |url=}}</ref><ref name="pmid21177423">{{cite journal |vauthors=Chen T, Surcel HM, Lundin E, Kaasila M, Lakso HA, Schock H, Kaaks R, Koskela P, Grankvist K, Hallmans G, Pukkala E, Zeleniuch-Jacquotte A, Toniolo P, Lehtinen M, Lukanova A |title=Circulating sex steroids during pregnancy and maternal risk of non-epithelial ovarian cancer |journal=Cancer Epidemiol. Biomarkers Prev. |volume=20 |issue=2 |pages=324–36 |date=February 2011 |pmid=21177423 |pmc=3082204 |doi=10.1158/1055-9965.EPI-10-0857 |url=}}</ref><ref name="pmid1329996">{{cite journal |vauthors=Horn-Ross PL, Whittemore AS, Harris R, Itnyre J |title=Characteristics relating to ovarian cancer risk: collaborative analysis of 12 U.S. case-control studies. VI. Nonepithelial cancers among adults. Collaborative Ovarian Cancer Group |journal=Epidemiology |volume=3 |issue=6 |pages=490–5 |date=November 1992 |pmid=1329996 |doi= |url=}}</ref> | |||
*Preterm birth is a risk factor for developing sex cord-stromal tumors | *Preterm birth is a risk factor for developing sex cord-stromal tumors | ||
*High gonadotropin levels in preterm girls could mediate disease risk by the proliferative and steroidogenic effects of FSH and LH on granulosa and theca cells | *High gonadotropin levels in preterm girls could mediate disease risk by the proliferative and steroidogenic effects of FSH and LH on granulosa and theca cells | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
There are no established risk factors for [disease name].
OR
The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].
OR
Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
OR
Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.
Risk Factors
There is very little data regarding the risk factors of sexcord-stromal ovarian tumors, however given below are some of the risk factors for the development of sexcord-stromal ovarian tumors: [1][2][3]
- Preterm birth is a risk factor for developing sex cord-stromal tumors
- High gonadotropin levels in preterm girls could mediate disease risk by the proliferative and steroidogenic effects of FSH and LH on granulosa and theca cells
- Maternal sex-cord stromal tumors are associated with high levels of androgens during pregnancy ( indicating that elevated androgens may also play a role in the pathogenesis of sex-cord stromal tumors)
- Pregnancy is a risk factor especially with increasing age at first term pregnancy
References
- ↑ Sieh W, Sundquist K, Sundquist J, Winkleby MA, Crump C (May 2014). "Intrauterine factors and risk of nonepithelial ovarian cancers". Gynecol. Oncol. 133 (2): 293–7. doi:10.1016/j.ygyno.2014.02.007. PMC 4006291. PMID 24530563.
- ↑ Chen T, Surcel HM, Lundin E, Kaasila M, Lakso HA, Schock H, Kaaks R, Koskela P, Grankvist K, Hallmans G, Pukkala E, Zeleniuch-Jacquotte A, Toniolo P, Lehtinen M, Lukanova A (February 2011). "Circulating sex steroids during pregnancy and maternal risk of non-epithelial ovarian cancer". Cancer Epidemiol. Biomarkers Prev. 20 (2): 324–36. doi:10.1158/1055-9965.EPI-10-0857. PMC 3082204. PMID 21177423.
- ↑ Horn-Ross PL, Whittemore AS, Harris R, Itnyre J (November 1992). "Characteristics relating to ovarian cancer risk: collaborative analysis of 12 U.S. case-control studies. VI. Nonepithelial cancers among adults. Collaborative Ovarian Cancer Group". Epidemiology. 3 (6): 490–5. PMID 1329996.