Oligodendroglioma laboratory tests: Difference between revisions
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===Immunohistochemical staining=== | ===Immunohistochemical staining=== | ||
*Oligodendrogliomas stain positive for: | *Oligodendrogliomas stain positive for: | ||
**R132H | **[[Isocitrate dehydrogenase|IDH1-R132H]] (majority of cases) | ||
**ATRX | **ATRX | ||
**GFAP (positive in intermingled reactive astrocytes and minigemistocytes) | **[[GFAP]] (positive in intermingled reactive astrocytes and minigemistocytes) | ||
**SOX10 | **SOX10 | ||
**MAP2 | **[[Microtubule-associated protein|MAP2]] | ||
**S100 | **[[S100 calcium binding protein A8|S-100]] | ||
**EMA | |||
**[[Ki-67 (Biology)|Ki-67]] | |||
**[[Neuron-Specific Enolase (NSE)|NSE]] | |||
**[[Synaptophysin]] | |||
**[[OLIG1]] | |||
**[[OLIG2]] | |||
*Oligodendrogliomas stain negative for: | *Oligodendrogliomas stain negative for: | ||
**p53 (rare weakly positive cells can be seen) | **p53 (rare weakly positive cells can be seen) |
Revision as of 13:33, 8 May 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2]Sujit Routray, M.D. [3]
Overview
Some patients with oligodendroglioma may have elevated protein and cell count with normal glucose and lactate on CSF analysis, which is usually suggestive of hydrocephalus.
Laboratory Findings
Lumbar Puncture
- Some patients with oligodendroglioma may have elevated protein and cell count with normal glucose and lactate on CSF analysis, which is usually suggestive of hydrocephalus[1][2]
Immunohistochemical staining
- Oligodendrogliomas stain positive for:
- IDH1-R132H (majority of cases)
- ATRX
- GFAP (positive in intermingled reactive astrocytes and minigemistocytes)
- SOX10
- MAP2
- S-100
- EMA
- Ki-67
- NSE
- Synaptophysin
- OLIG1
- OLIG2
- Oligodendrogliomas stain negative for:
- p53 (rare weakly positive cells can be seen)
- Keratins (although cocktails may show cross reactivity)
References
- ↑ Stark AM, Hugo HH, Mehdorn HM, Knerlich-Lukoschus F (2009). "Acute Hydrocephalus due to Secondary Leptomeningeal Dissemination of an Anaplastic Oligodendroglioma". Case Rep Med. 2009: 370901. doi:10.1155/2009/370901. PMC 2797365. PMID 20052406.
- ↑ Li KW, Roonprapunt C, Lawson HC, Abbott IR, Wisoff J, Epstein F; et al. (2005). "Endoscopic third ventriculostomy for hydrocephalus associated with tectal gliomas". Neurosurg Focus. 18 (6A): E2. PMID 16048288.