Testicular cancer laboratory findings: Difference between revisions
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{{CMG}}; {{AE}} {{G.D.}}, {{SC}} | {{CMG}}; {{AE}} {{G.D.}}, {{SC}} | ||
==Overview== | ==Overview== | ||
An elevated concentration of blood [[tumor marker]] tests is diagnostic of testicular cancer. | An elevated concentration of [[blood]] [[tumor marker]] tests is [[diagnostic]] of testicular cancer. | ||
==Laboratory Tests== | ==Laboratory Tests== | ||
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! align="center" style="background:#DCDCDC;" + |Seminoma | ! align="center" style="background:#DCDCDC;" + |Seminoma | ||
| align="center" style="background:#F5F5F5;" + |↑ | | align="center" style="background:#F5F5F5;" + |↑ | ||
| align="center" style="background:#F5F5F5;" + |- | | align="center" style="background:#F5F5F5;" + | - | ||
| align="center" style="background:#F5F5F5;" + |↑ | | align="center" style="background:#F5F5F5;" + |↑ | ||
|- | |- | ||
! align="center" style="background:#DCDCDC;" + |Choriocarcinoma | ! align="center" style="background:#DCDCDC;" + |Choriocarcinoma | ||
| align="center" style="background:#F5F5F5;" + |↑↑ | | align="center" style="background:#F5F5F5;" + |↑↑ | ||
| align="center" style="background:#F5F5F5;" + |- | | align="center" style="background:#F5F5F5;" + | - | ||
| align="center" style="background:#F5F5F5;" + |↑ | | align="center" style="background:#F5F5F5;" + |↑ | ||
|- | |- | ||
! align="center" style="background:#DCDCDC;" + |Yolk sac tumor | ! align="center" style="background:#DCDCDC;" + |Yolk sac tumor | ||
| align="center" style="background:#F5F5F5;" + |- | | align="center" style="background:#F5F5F5;" + | - | ||
| align="center" style="background:#F5F5F5;" + |↑ | | align="center" style="background:#F5F5F5;" + |↑ | ||
| align="center" style="background:#F5F5F5;" + |↑ | | align="center" style="background:#F5F5F5;" + |↑ | ||
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|- | |- | ||
! align="center" style="background:#DCDCDC;" + |Teratoma | ! align="center" style="background:#DCDCDC;" + |Teratoma | ||
| align="center" style="background:#F5F5F5;" + |- | | align="center" style="background:#F5F5F5;" + | - | ||
| align="center" style="background:#F5F5F5;" + |↑ | | align="center" style="background:#F5F5F5;" + |↑ | ||
| align="center" style="background:#F5F5F5;" + |↑ | | align="center" style="background:#F5F5F5;" + |↑ | ||
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==Sex cord stromal testicular tumor== | ==Sex cord stromal testicular tumor== | ||
Leydig cell tumor<ref name="pmid17284120">{{cite journal |vauthors=Al-Agha OM, Axiotis CA |title=An in-depth look at Leydig cell tumor of the testis |journal=Arch. Pathol. Lab. Med. |volume=131 |issue=2 |pages=311–7 |date=February 2007 |pmid=17284120 |doi=10.1043/1543-2165(2007)131[311:AILALC]2.0.CO;2 |url=}}</ref> | Leydig cell tumor<ref name="pmid17284120">{{cite journal |vauthors=Al-Agha OM, Axiotis CA |title=An in-depth look at Leydig cell tumor of the testis |journal=Arch. Pathol. Lab. Med. |volume=131 |issue=2 |pages=311–7 |date=February 2007 |pmid=17284120 |doi=10.1043/1543-2165(2007)131[311:AILALC]2.0.CO;2 |url=}}</ref> | ||
*Estrogen or androgen is elevated | *[[Estrogen]] or [[androgen]] is elevated | ||
*ACTH (adrenocorticothrophic hormone) is elevated | *[[ACTH]] (adrenocorticothrophic hormone) is elevated | ||
Sertoli cell tumor<ref name="pmid17284120">{{cite journal |vauthors=Al-Agha OM, Axiotis CA |title=An in-depth look at Leydig cell tumor of the testis |journal=Arch. Pathol. Lab. Med. |volume=131 |issue=2 |pages=311–7 |date=February 2007 |pmid=17284120 |doi=10.1043/1543-2165(2007)131[311:AILALC]2.0.CO;2 |url=}}</ref> | Sertoli cell tumor<ref name="pmid17284120">{{cite journal |vauthors=Al-Agha OM, Axiotis CA |title=An in-depth look at Leydig cell tumor of the testis |journal=Arch. Pathol. Lab. Med. |volume=131 |issue=2 |pages=311–7 |date=February 2007 |pmid=17284120 |doi=10.1043/1543-2165(2007)131[311:AILALC]2.0.CO;2 |url=}}</ref> | ||
*Estrogen is elevated | *[[Estrogen]] is elevated | ||
==References== | ==References== | ||
Latest revision as of 10:42, 28 May 2019
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Testicular cancer Microchapters |
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Testicular cancer laboratory findings On the Web |
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American Roentgen Ray Society Images of Testicular cancer laboratory findings |
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Risk calculators and risk factors for Testicular cancer laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Shanshan Cen, M.D. [3]
Overview
An elevated concentration of blood tumor marker tests is diagnostic of testicular cancer.
Laboratory Tests
| Tumor type | Tumor markers | ||
|---|---|---|---|
| Human chorionic gonadotropin (HCG) | Alpha-fetoprotein (AFP) | Lactate dehydrogenase (LDH) | |
| Seminoma | ↑ | - | ↑ |
| Choriocarcinoma | ↑↑ | - | ↑ |
| Yolk sac tumor | - | ↑ | ↑ |
| Embryonal tumor | ↑ | ↑ | ↑ |
| Teratoma | - | ↑ | ↑ |
Sex cord stromal testicular tumor
Leydig cell tumor[3]
Sertoli cell tumor[3]
- Estrogen is elevated
References
- ↑ Milose JC, Filson CP, Weizer AZ, Hafez KS, Montgomery JS (December 2011). "Role of biochemical markers in testicular cancer: diagnosis, staging, and surveillance". Open Access J Urol. 4: 1–8. doi:10.2147/OAJU.S15063. PMC 3818947. PMID 24198649.
- ↑ Gilligan TD, Seidenfeld J, Basch EM, Einhorn LH, Fancher T, Smith DC, Stephenson AJ, Vaughn DJ, Cosby R, Hayes DF (July 2010). "American Society of Clinical Oncology Clinical Practice Guideline on uses of serum tumor markers in adult males with germ cell tumors". J. Clin. Oncol. 28 (20): 3388–404. doi:10.1200/JCO.2009.26.4481. PMID 20530278.
- ↑ 3.0 3.1 Al-Agha OM, Axiotis CA (February 2007). "An in-depth look at Leydig cell tumor of the testis". Arch. Pathol. Lab. Med. 131 (2): 311–7. doi:10.1043/1543-2165(2007)131[311:AILALC]2.0.CO;2. PMID 17284120.