Radiation proctitis medical therapy: Difference between revisions
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==Medical Therapy== | ==Medical Therapy== | ||
* Symptoms such as diarrhea and painful defectation may be treated with oral [[opioids]] and stool softeners, respectively. | * Symptoms such as diarrhea and painful defectation may be treated with oral [[opioids]] and stool softeners, respectively. | ||
* Several other methods are under development as of 2005 to lessen the effects of radiation proctitis. These include [[sucralfate]], [[hyperbaric oxygen therapy]], [[corticosteroid]]s, [[metronidazole]], and [[argon plasma coagulation]].<ref name="pmid1670631">{{cite journal| author=Kochhar R, Patel F, Dhar A, Sharma SC, Ayyagari S, Aggarwal R et al.| title=Radiation-induced proctosigmoiditis. Prospective, randomized, double-blind controlled trial of oral sulfasalazine plus rectal steroids versus rectal sucralfate. | journal=Dig Dis Sci | year= 1991 | volume= 36 | issue= 1 | pages= 103-7 | pmid=1670631 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1670631 }}</ref><ref name="pmid9293933">{{cite journal| author=Talley NA, Chen F, King D, Jones M, Talley NJ| title=Short-chain fatty acids in the treatment of radiation proctitis: a randomized, double-blind, placebo-controlled, cross-over pilot trial. | journal=Dis Colon Rectum | year= 1997 | volume= 40 | issue= 9 | pages= 1046-50 | pmid=9293933 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9293933 }}</ref><ref name="pmid9013165">{{cite journal| author=Jensen DM, Machicado GA, Cheng S, Jensen ME, Jutabha R| title=A randomized prospective study of endoscopic bipolar electrocoagulation and heater probe treatment of chronic rectal bleeding from radiation telangiectasia. | journal=Gastrointest Endosc | year= 1997 | volume= 45 | issue= 1 | pages= 20-5 | pmid=9013165 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9013165 }}</ref><ref name="pmid10378604">{{cite journal| author=Pinto A, Fidalgo P, Cravo M, Midões J, Chaves P, Rosa J et al.| title=Short chain fatty acids are effective in short-term treatment of chronic radiation proctitis: randomized, double-blind, controlled trial. | journal=Dis Colon Rectum | year= 1999 | volume= 42 | issue= 6 | pages= 788-95; discussion 795-6 | pmid=10378604 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10378604 }}</ref> | * Several other methods are under development as of 2005 to lessen the effects of radiation proctitis. These include [[sucralfate]], [[hyperbaric oxygen therapy]], [[corticosteroid]]s, [[metronidazole]], and [[argon plasma coagulation]].<ref name="pmid1670631">{{cite journal| author=Kochhar R, Patel F, Dhar A, Sharma SC, Ayyagari S, Aggarwal R et al.| title=Radiation-induced proctosigmoiditis. Prospective, randomized, double-blind controlled trial of oral sulfasalazine plus rectal steroids versus rectal sucralfate. | journal=Dig Dis Sci | year= 1991 | volume= 36 | issue= 1 | pages= 103-7 | pmid=1670631 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1670631 }}</ref><ref name="pmid9293933">{{cite journal| author=Talley NA, Chen F, King D, Jones M, Talley NJ| title=Short-chain fatty acids in the treatment of radiation proctitis: a randomized, double-blind, placebo-controlled, cross-over pilot trial. | journal=Dis Colon Rectum | year= 1997 | volume= 40 | issue= 9 | pages= 1046-50 | pmid=9293933 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9293933 }}</ref><ref name="pmid9013165">{{cite journal| author=Jensen DM, Machicado GA, Cheng S, Jensen ME, Jutabha R| title=A randomized prospective study of endoscopic bipolar electrocoagulation and heater probe treatment of chronic rectal bleeding from radiation telangiectasia. | journal=Gastrointest Endosc | year= 1997 | volume= 45 | issue= 1 | pages= 20-5 | pmid=9013165 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9013165 }}</ref><ref name="pmid10378604">{{cite journal| author=Pinto A, Fidalgo P, Cravo M, Midões J, Chaves P, Rosa J et al.| title=Short chain fatty acids are effective in short-term treatment of chronic radiation proctitis: randomized, double-blind, controlled trial. | journal=Dis Colon Rectum | year= 1999 | volume= 42 | issue= 6 | pages= 788-95; discussion 795-6 | pmid=10378604 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10378604 }}</ref><ref name="pmid10962052">{{cite journal| author=Cavcić J, Turcić J, Martinac P, Jelincić Z, Zupancić B, Panijan-Pezerović R et al.| title=Metronidazole in the treatment of chronic radiation proctitis: clinical trial. | journal=Croat Med J | year= 2000 | volume= 41 | issue= 3 | pages= 314-8 | pmid=10962052 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10962052 }}</ref> | ||
==References== | ==References== | ||
Revision as of 08:20, 30 May 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Medical Therapy
- Symptoms such as diarrhea and painful defectation may be treated with oral opioids and stool softeners, respectively.
- Several other methods are under development as of 2005 to lessen the effects of radiation proctitis. These include sucralfate, hyperbaric oxygen therapy, corticosteroids, metronidazole, and argon plasma coagulation.[2][3][4][5][6]
References
- ↑ Tabaja L, Sidani SM (2018). "Management of Radiation Proctitis". Dig Dis Sci. 63 (9): 2180–2188. doi:10.1007/s10620-018-5163-8. PMID 29948565.
- ↑ Kochhar R, Patel F, Dhar A, Sharma SC, Ayyagari S, Aggarwal R; et al. (1991). "Radiation-induced proctosigmoiditis. Prospective, randomized, double-blind controlled trial of oral sulfasalazine plus rectal steroids versus rectal sucralfate". Dig Dis Sci. 36 (1): 103–7. PMID 1670631.
- ↑ Talley NA, Chen F, King D, Jones M, Talley NJ (1997). "Short-chain fatty acids in the treatment of radiation proctitis: a randomized, double-blind, placebo-controlled, cross-over pilot trial". Dis Colon Rectum. 40 (9): 1046–50. PMID 9293933.
- ↑ Jensen DM, Machicado GA, Cheng S, Jensen ME, Jutabha R (1997). "A randomized prospective study of endoscopic bipolar electrocoagulation and heater probe treatment of chronic rectal bleeding from radiation telangiectasia". Gastrointest Endosc. 45 (1): 20–5. PMID 9013165.
- ↑ Pinto A, Fidalgo P, Cravo M, Midões J, Chaves P, Rosa J; et al. (1999). "Short chain fatty acids are effective in short-term treatment of chronic radiation proctitis: randomized, double-blind, controlled trial". Dis Colon Rectum. 42 (6): 788–95, discussion 795-6. PMID 10378604.
- ↑ Cavcić J, Turcić J, Martinac P, Jelincić Z, Zupancić B, Panijan-Pezerović R; et al. (2000). "Metronidazole in the treatment of chronic radiation proctitis: clinical trial". Croat Med J. 41 (3): 314–8. PMID 10962052.