Radiation proctitis risk factors: Difference between revisions
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*Less common risk factors in the development of Radiation proctitis are the diseases that may increases the susceptibility of mucosal injury by radiation are: | *Less common risk factors in the development of Radiation proctitis are the diseases that may increases the susceptibility of mucosal injury by radiation are: | ||
**HIV<ref name="pmid10219805">{{cite journal| author=Hoffman R, Welton ML, Klencke B, Weinberg V, Krieg R| title=The significance of pretreatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer. | journal=Int J Radiat Oncol Biol Phys | year= 1999 | volume= 44 | issue= 1 | pages= 127-31 | pmid=10219805 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10219805 }}</ref> | **HIV<ref name="pmid10219805">{{cite journal| author=Hoffman R, Welton ML, Klencke B, Weinberg V, Krieg R| title=The significance of pretreatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer. | journal=Int J Radiat Oncol Biol Phys | year= 1999 | volume= 44 | issue= 1 | pages= 127-31 | pmid=10219805 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10219805 }}</ref> | ||
**Immunosuppresion<ref name="pmid20014399">{{cite journal| author=Housri N, Yarchoan R, Kaushal A| title=Radiotherapy for patients with the human immunodeficiency virus: are special precautions necessary? | journal=Cancer | year= 2010 | volume= 116 | issue= 2 | pages= 273-83 | pmid=20014399 | doi=10.1002/cncr.24878 | pmc=3409663 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20014399 }}</ref> | |||
**Inflammatory bowel disease | **Inflammatory bowel disease | ||
**Hx of smoking | **Hx of smoking | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:
Overview
Common risk factors in the development of Radiation proctitis include include dose of radiation, area of the radiation and mode of delivery of the radiation.
Risk Factors
Common Risk Factors
- Common risk factors in the development of radiation proctitis include:[1][2]
- Dose of the radiation: <45 Gy are associated with few long-term radiation side effects. In contrast, doses between 45 and 70 Gy cause more complications, and doses above 70 Gy cause significant and longstanding injury to the surrounding area
- Area of the radiation[3]
- Mode of the delivery of the radiation External beam radiation, typically administered by a linear accelerator, results in significantly greater exposure to surrounding organs as compared with brachytherapy, where radiation is administered via radioactive implants. Newer modalities of external beam radiation delivery, including three-dimensional conformal radiation therapy, intensity-modulated radiation therapy, and the use of heavy particles including protons and neutrons, may be associated with a reduced risk of radiation toxicity.
Less Common Risk Factors
- Less common risk factors in the development of Radiation proctitis are the diseases that may increases the susceptibility of mucosal injury by radiation are:
References
- ↑ Beard CJ, Propert KJ, Rieker PP, Clark JA, Kaplan I, Kantoff PW; et al. (1997). "Complications after treatment with external-beam irradiation in early-stage prostate cancer patients: a prospective multiinstitutional outcomes study". J Clin Oncol. 15 (1): 223–9. doi:10.1200/JCO.1997.15.1.223. PMID 8996146.
- ↑ Coia LR, Myerson RJ, Tepper JE (1995). "Late effects of radiation therapy on the gastrointestinal tract". Int J Radiat Oncol Biol Phys. 31 (5): 1213–36. doi:10.1016/0360-3016(94)00419-L. PMID 7713784.
- ↑ Willett CG, Ooi CJ, Zietman AL, Menon V, Goldberg S, Sands BE; et al. (2000). "Acute and late toxicity of patients with inflammatory bowel disease undergoing irradiation for abdominal and pelvic neoplasms". Int J Radiat Oncol Biol Phys. 46 (4): 995–8. PMID 10705022.
- ↑ Hoffman R, Welton ML, Klencke B, Weinberg V, Krieg R (1999). "The significance of pretreatment CD4 count on the outcome and treatment tolerance of HIV-positive patients with anal cancer". Int J Radiat Oncol Biol Phys. 44 (1): 127–31. PMID 10219805.
- ↑ Housri N, Yarchoan R, Kaushal A (2010). "Radiotherapy for patients with the human immunodeficiency virus: are special precautions necessary?". Cancer. 116 (2): 273–83. doi:10.1002/cncr.24878. PMC 3409663. PMID 20014399.