Uveal melanoma history and symptoms: Difference between revisions
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Symptoms of uveal melanoma include [[eye pain]], [[eye]] redness, loss of [[peripheral vision]], poor or [[blurry vision]] in one [[eye]], a dark spot on the [[iris]], flashing lights, floaters, and symptoms of [[glaucoma]].<ref name="pmid23826405">{{cite journal| author=Jovanovic P, Mihajlovic M, Djordjevic-Jocic J, Vlajkovic S, Cekic S, Stefanovic V| title=Ocular melanoma: an overview of the current status. | journal=Int J Clin Exp Pathol | year= 2013 | volume= 6 | issue= 7 | pages= 1230-44 | pmid=23826405 | doi= | pmc=PMC3693189 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23826405 }} </ref> | Symptoms of uveal melanoma include [[eye pain]], [[eye]] redness, loss of [[peripheral vision]], poor or [[blurry vision]] in one [[eye]], a dark spot on the [[iris]], flashing lights, floaters, and symptoms of [[glaucoma]].<ref name="pmid23826405">{{cite journal| author=Jovanovic P, Mihajlovic M, Djordjevic-Jocic J, Vlajkovic S, Cekic S, Stefanovic V| title=Ocular melanoma: an overview of the current status. | journal=Int J Clin Exp Pathol | year= 2013 | volume= 6 | issue= 7 | pages= 1230-44 | pmid=23826405 | doi= | pmc=PMC3693189 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23826405 }} </ref> | ||
==History== | ==History== | ||
Patients with uveal melanoma may have a positive history of: | Patients with uveal melanoma may have a positive history of:<ref name="EganSeddon1988">{{cite journal|last1=Egan|first1=Kathleen M.|last2=Seddon|first2=Johanna M.|last3=Glynn|first3=Robert J.|last4=Gragoudas|first4=Evangelos S.|last5=Albert|first5=Daniel M.|title=Epidemiologic aspects of uveal melanoma|journal=Survey of Ophthalmology|volume=32|issue=4|year=1988|pages=239–251|issn=00396257|doi=10.1016/0039-6257(88)90173-7}}</ref><ref name="NCI">Uveal melanoma. National Cancer Institute(2015) http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq Accessed on October 24 2015</ref><ref name="vanKoopmans2013">{{cite journal|last1=van|first1=J.G.M.|last2=Koopmans|first2=A.E.|last3=Verdijk|first3=R.M.|last4=Naus|first4=N.C.|last5=de|first5=A.|last6=Kilic|first6=E.|title=Diagnosis, Histopathologic and Genetic Classification of Uveal Melanoma|year=2013|doi=10.5772/53631}}</ref><ref name="Reese1944">{{cite journal|last1=Reese|first1=Algernon B.|title=Pigment Freckles of the Iris (Benign Melanomas): Their Significance in Relation to Malignant Melanoma of the Uvea⋆|journal=American Journal of Ophthalmology|volume=27|issue=3|year=1944|pages=217–226|issn=00029394|doi=10.1016/S0002-9394(44)91382-6}}</ref><ref name="Siegel1963">{{cite journal|last1=Siegel|first1=Ralph|title=Malignant Ocular Melanoma During Pregnancy|journal=JAMA: The Journal of the American Medical Association|volume=185|issue=6|year=1963|pages=542|issn=0098-7484|doi=10.1001/jama.1963.03060060140028}}</ref><ref name="FisherKripke1982">{{cite journal|last1=Fisher|first1=M.|last2=Kripke|first2=M.|title=Suppressor T lymphocytes control the development of primary skin cancers in ultraviolet-irradiated mice|journal=Science|volume=216|issue=4550|year=1982|pages=1133–1134|issn=0036-8075|doi=10.1126/science.6210958}}</ref><ref>{{cite journal|title=Risk Factors for Ocular Melanoma: Western Canada Melanoma Study<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>|journal=JNCI: Journal of the National Cancer Institute|year=1985|issn=1460-2105|doi=10.1093/jnci/74.4.775}}</ref><ref name="TuckerShields1985">{{cite journal|last1=Tucker|first1=Margaret A.|last2=Shields|first2=Jerry A.|last3=Hartge|first3=Patricia|last4=Augsburger|first4=James|last5=Hoover|first5=Robert N.|last6=Fraumeni|first6=Joseph F.|title=Sunlight Exposure as Risk Factor for Intraocular Malignant Melanoma|journal=New England Journal of Medicine|volume=313|issue=13|year=1985|pages=789–792|issn=0028-4793|doi=10.1056/NEJM198509263131305}}</ref><ref name="BabaBlumenkranz1986">{{cite journal|last1=Baba|first1=F. E.|last2=Blumenkranz|first2=M.|title=Malignant Melanoma at the Site of Penetrating Ocular Trauma|journal=Archives of Ophthalmology|volume=104|issue=3|year=1986|pages=405–409|issn=0003-9950|doi=10.1001/archopht.1986.01050150105038}}</ref><ref name="BeralShaw1982">{{cite journal|last1=Beral|first1=Valerie|last2=Shaw|first2=Helen|last3=Evans|first3=Susan|last4=Milton|first4=Gerald|title=MALIGNANT MELANOMA AND EXPOSURE TO FLUORESCENT LIGHTING AT WORK|journal=The Lancet|volume=320|issue=8293|year=1982|pages=290–293|issn=01406736|doi=10.1016/S0140-6736(82)90270-7}}</ref> | ||
* Pre-existing iris nevus which increased in size | * Pre-existing iris nevus which increased in size | ||
* Eye pain | * Eye pain | ||
| Line 11: | Line 11: | ||
* Blurred vision | * Blurred vision | ||
* Floaters | * Floaters | ||
* Age between 50_70 years old | |||
* Male gender | |||
* | * white race | ||
* | * Pregnancy | ||
* Impaired immune system | |||
* light colored-irides | |||
* Sunlight exposure | |||
* Trauma | |||
* Fluorescent lighting exposure | |||
==Symptoms== | ==Symptoms== | ||
Clinical presentation depends on the location. When the tumor is located on the [[iris]] then it may be apparent to the patient or friends and family as a brown nodule. [[Choroidal]] or [[ciliary body]] [[tumors]] are only identified incidentally on [[fundoscopy]] or as a result of [[retinal detachment]] or advanced disease.<ref name="radio">Retinoblastoma. Radiopedia(2015) http://radiopaedia.org/articles/primary-uveal-malignant-melanoma Accessed on October 21, 2015</ref> The majority of patients with uveal melanoma are symptomatic at the time of diagnosis, but up to 30% patients could be asymptomatic. Many cases of uveal melanoma are found during routine eye examination. | Clinical presentation depends on the location. When the tumor is located on the [[iris]] then it may be apparent to the patient or friends and family as a brown nodule. [[Choroidal]] or [[ciliary body]] [[tumors]] are only identified incidentally on [[fundoscopy]] or as a result of [[retinal detachment]] or advanced disease.<ref name="radio">Retinoblastoma. Radiopedia(2015) http://radiopaedia.org/articles/primary-uveal-malignant-melanoma Accessed on October 21, 2015</ref> The majority of patients with uveal melanoma are symptomatic at the time of diagnosis, but up to 30% patients could be asymptomatic. Many cases of uveal melanoma are found during routine eye examination. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]
Overview
Symptoms of uveal melanoma include eye pain, eye redness, loss of peripheral vision, poor or blurry vision in one eye, a dark spot on the iris, flashing lights, floaters, and symptoms of glaucoma.[1]
History
Patients with uveal melanoma may have a positive history of:[2][3][4][5][6][7][8][9][10][11]
- Pre-existing iris nevus which increased in size
- Eye pain
- Visual loss
- Blurred vision
- Floaters
- Age between 50_70 years old
- Male gender
- white race
- Pregnancy
- Impaired immune system
- light colored-irides
- Sunlight exposure
- Trauma
- Fluorescent lighting exposure
Symptoms
Clinical presentation depends on the location. When the tumor is located on the iris then it may be apparent to the patient or friends and family as a brown nodule. Choroidal or ciliary body tumors are only identified incidentally on fundoscopy or as a result of retinal detachment or advanced disease.[12] The majority of patients with uveal melanoma are symptomatic at the time of diagnosis, but up to 30% patients could be asymptomatic. Many cases of uveal melanoma are found during routine eye examination. Common symptoms of uveal melanoma include:[1]
- Eye pain
- Eye redness
- Loss of peripheral vision
- Poor or blurry vision in one eye
- A dark spot on the iris
- Seeing flashing lights
- Floaters
- Symptoms of glaucoma
- Severe headache
- Nausea and vomiting
- Blurred vision
- Halos around lights
References
- ↑ 1.0 1.1 Jovanovic P, Mihajlovic M, Djordjevic-Jocic J, Vlajkovic S, Cekic S, Stefanovic V (2013). "Ocular melanoma: an overview of the current status". Int J Clin Exp Pathol. 6 (7): 1230–44. PMC 3693189. PMID 23826405.
- ↑ Egan, Kathleen M.; Seddon, Johanna M.; Glynn, Robert J.; Gragoudas, Evangelos S.; Albert, Daniel M. (1988). "Epidemiologic aspects of uveal melanoma". Survey of Ophthalmology. 32 (4): 239–251. doi:10.1016/0039-6257(88)90173-7. ISSN 0039-6257.
- ↑ Uveal melanoma. National Cancer Institute(2015) http://www.cancer.gov/types/eye/hp/intraocular-melanoma-treatment-pdq Accessed on October 24 2015
- ↑ van, J.G.M.; Koopmans, A.E.; Verdijk, R.M.; Naus, N.C.; de, A.; Kilic, E. (2013). "Diagnosis, Histopathologic and Genetic Classification of Uveal Melanoma". doi:10.5772/53631.
- ↑ Reese, Algernon B. (1944). "Pigment Freckles of the Iris (Benign Melanomas): Their Significance in Relation to Malignant Melanoma of the Uvea⋆". American Journal of Ophthalmology. 27 (3): 217–226. doi:10.1016/S0002-9394(44)91382-6. ISSN 0002-9394.
- ↑ Siegel, Ralph (1963). "Malignant Ocular Melanoma During Pregnancy". JAMA: The Journal of the American Medical Association. 185 (6): 542. doi:10.1001/jama.1963.03060060140028. ISSN 0098-7484.
- ↑ Fisher, M.; Kripke, M. (1982). "Suppressor T lymphocytes control the development of primary skin cancers in ultraviolet-irradiated mice". Science. 216 (4550): 1133–1134. doi:10.1126/science.6210958. ISSN 0036-8075.
- ↑ "Risk Factors for Ocular Melanoma: Western Canada Melanoma Study<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>". JNCI: Journal of the National Cancer Institute. 1985. doi:10.1093/jnci/74.4.775. ISSN 1460-2105.
- ↑ Tucker, Margaret A.; Shields, Jerry A.; Hartge, Patricia; Augsburger, James; Hoover, Robert N.; Fraumeni, Joseph F. (1985). "Sunlight Exposure as Risk Factor for Intraocular Malignant Melanoma". New England Journal of Medicine. 313 (13): 789–792. doi:10.1056/NEJM198509263131305. ISSN 0028-4793.
- ↑ Baba, F. E.; Blumenkranz, M. (1986). "Malignant Melanoma at the Site of Penetrating Ocular Trauma". Archives of Ophthalmology. 104 (3): 405–409. doi:10.1001/archopht.1986.01050150105038. ISSN 0003-9950.
- ↑ Beral, Valerie; Shaw, Helen; Evans, Susan; Milton, Gerald (1982). "MALIGNANT MELANOMA AND EXPOSURE TO FLUORESCENT LIGHTING AT WORK". The Lancet. 320 (8293): 290–293. doi:10.1016/S0140-6736(82)90270-7. ISSN 0140-6736.
- ↑ Retinoblastoma. Radiopedia(2015) http://radiopaedia.org/articles/primary-uveal-malignant-melanoma Accessed on October 21, 2015