Waldenström's macroglobulinemia bone marrow aspiration and biopsy: Difference between revisions
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== Bone Marrow Biopsy == | == Bone Marrow Biopsy == | ||
A [[bone marrow biopsy]] may be helpful in the diagnosis of Waldenström macroglobulinemia. <ref name="pmid18555588">{{cite journal| author=Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J et al.| title=Waldenstrom macroglobulinemia. | journal=Cancer Lett | year= 2008 | volume= 270 | issue= 1 | pages= 95-107 | pmid=18555588 | doi=10.1016/j.canlet.2008.04.040 | pmc=3133633 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18555588 }} </ref> | A [[bone marrow biopsy]] may be helpful in the [[diagnosis]] of [[Waldenström macroglobulinemia]]. <ref name="pmid18555588">{{cite journal| author=Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J et al.| title=Waldenstrom macroglobulinemia. | journal=Cancer Lett | year= 2008 | volume= 270 | issue= 1 | pages= 95-107 | pmid=18555588 | doi=10.1016/j.canlet.2008.04.040 | pmc=3133633 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18555588 }} </ref> | ||
Findings on the biopsy suggestive of Waldenström macroglobulinemia include:<ref name="pmid18555588">{{cite journal| author=Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J et al.| title=Waldenstrom macroglobulinemia. | journal=Cancer Lett | year= 2008 | volume= 270 | issue= 1 | pages= 95-107 | pmid=18555588 | doi=10.1016/j.canlet.2008.04.040 | pmc=3133633 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18555588 }} </ref> | Findings on the [[biopsy]] [[Suggestion|suggestive]] of [[Waldenström macroglobulinemia]] include:<ref name="pmid18555588">{{cite journal| author=Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J et al.| title=Waldenstrom macroglobulinemia. | journal=Cancer Lett | year= 2008 | volume= 270 | issue= 1 | pages= 95-107 | pmid=18555588 | doi=10.1016/j.canlet.2008.04.040 | pmc=3133633 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18555588 }} </ref> | ||
* Hypercellular and [[Infiltration (medical)|infiltrated]] with [[lymphoid]] and [[Plasmacytoid|plasmacytoid cells]]. | * Hypercellular and [[Infiltration (medical)|infiltrated]] with [[lymphoid]] and [[Plasmacytoid|plasmacytoid cells]]. | ||
* Dutcher bodies (PAS positive intra-nuclear vacuoles containing [[IgM]] monoclonal protein). | * Dutcher [[Body|bodies]] ([[PAS stain|PAS]] positive intra-[[nuclear]] [[vacuoles]] containing [[IgM]] [[Monoclonal antibody|monoclonal]] [[protein]]). | ||
** Characteristic feature of Waldenström macroglobulinemia. | **[[Characteristic function (probability theory)|Characteristic]] [[Features (pattern recognition)|feature]] of [[Waldenström macroglobulinemia]]. | ||
Three patterns of marrow involvement are described, as follows: | |||
* Lymphoplasmacytoid cells ([[Lymphoplasmacytic lymphoma|lymphoplasmacytic]] and small lymphocytes) in a nodular pattern. | Three [[Pattern|patterns]] of [[Bone marrow|marrow]] involvement are described, as follows: | ||
* Lymphoplasmacytic cells (small lymphocytes, mature plasma cells, mast cells) in an interstitial/nodular pattern. | * Lymphoplasmacytoid [[Cells (biology)|cells]] ([[Lymphoplasmacytic lymphoma|lymphoplasmacytic]] and small [[lymphocytes]]) in a [[nodular]] [[pattern]]. | ||
* A polymorphous infiltrate (small lymphocytes, plasma cells, plasmacytoid cells, immunoblasts with mitotic figures). | * Lymphoplasmacytic [[Cells (biology)|cells]] (small [[lymphocytes]], mature [[plasma cells]], [[mast cells]]) in an [[interstitial]]/[[nodular]] [[pattern]]. | ||
* A polymorphous [[Infiltration (medical)|infiltrate]] (small [[lymphocytes]], [[plasma cells]], [[plasmacytoid]] [[Cells (biology)|cells]], [[Immunoblast|immunoblasts]] with [[mitotic]] figures). | |||
==References== | ==References== | ||
Revision as of 23:00, 14 August 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Mohsin, M.D.[2] Roukoz A. Karam, M.D.[3]; Grammar Reviewer: Natalie Harpenau, B.S.[4]
Overview
A bone marrow aspiration is essential in the diagnosis of Waldenström macroglobulinemia.
Bone Marrow Aspirate
A bone marrow aspirate is essential in the diagnosis of Waldenström macroglobulinemia.
Findings suggestive of Waldenström macroglobulinemia include:[1]
- A hypercellular bone marrow aspirate.
- Lymphoplasmacytic infiltrate with characteristic immunophenotype.
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Bone Marrow Biopsy
A bone marrow biopsy may be helpful in the diagnosis of Waldenström macroglobulinemia. [1]
Findings on the biopsy suggestive of Waldenström macroglobulinemia include:[1]
- Hypercellular and infiltrated with lymphoid and plasmacytoid cells.
Three patterns of marrow involvement are described, as follows:
- Lymphoplasmacytoid cells (lymphoplasmacytic and small lymphocytes) in a nodular pattern.
- Lymphoplasmacytic cells (small lymphocytes, mature plasma cells, mast cells) in an interstitial/nodular pattern.
- A polymorphous infiltrate (small lymphocytes, plasma cells, plasmacytoid cells, immunoblasts with mitotic figures).
References
- ↑ 1.0 1.1 1.2 Leleu X, Roccaro AM, Moreau AS, Dupire S, Robu D, Gay J; et al. (2008). "Waldenstrom macroglobulinemia". Cancer Lett. 270 (1): 95–107. doi:10.1016/j.canlet.2008.04.040. PMC 3133633. PMID 18555588.