Acinic cell carcinoma differential diagnosis: Difference between revisions
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===Differentiating acinic cell carcinoma from other diseases on the basis of histology findings=== | ===Differentiating acinic cell carcinoma from other diseases on the basis of histology findings=== | ||
On the basis of histologic findings acinic cell carcinoma must be differentiated from other salivary and head and neck masses such as salivary metastasis of thyroid carcinoma, salivary oncocytoma, mucoepidermoid carcinoma, inconspicuous mucous/squamoid cells, Mammary analog secretory carcinoma. | On the basis of histologic findings acinic cell carcinoma must be differentiated from other salivary and head and neck masses such as salivary metastasis of thyroid carcinoma, salivary oncocytoma, mucoepidermoid carcinoma, inconspicuous mucous/squamoid cells, Mammary analog secretory carcinoma.<ref>{{cite journal|title=Tumors of the Salivary Glands, Atlas of Tumor Pathology: Third Series, Fascicle 17 G. L. Ellis and P. L. Auclair. Armed Forces Institute of Pathology, Washington D.C. ISBN: 1 881041 26 3 (Printed). 1996. Price: $69.00. ISBN: 1 881041 41 7 (CD-ROM). 1998. Price: $65.00|journal=The Journal of Pathology|volume=192|issue=4|year=2000|pages=564–565|issn=0022-3417|doi=10.1002/1096-9896(200012)192:4<564::AID-PATH737>3.0.CO;2-M}}</ref><ref name="Kumar2017">{{cite journal|last1=Kumar|first1=Uma|title=Acinic Cell Carcinoma Papillary-Cystic Variant: Diagnostic Pitfalls in Fine Needle Aspiration Cytology|journal=JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH|year=2017|issn=2249782X|doi=10.7860/JCDR/2017/21347.9772}}</ref> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
Differentiating acinic cell carcinoma from other Diseases
Differentiating acinic cell carcinoma from other diseases on the basis of histology findings
On the basis of histologic findings acinic cell carcinoma must be differentiated from other salivary and head and neck masses such as salivary metastasis of thyroid carcinoma, salivary oncocytoma, mucoepidermoid carcinoma, inconspicuous mucous/squamoid cells, Mammary analog secretory carcinoma.[1][2]
| Histological findings | ||
|---|---|---|
| Diseases | Overlapping features | Distinguishing features |
| Salivary metastasis of thyroid carcinoma | Empty appearance, grooves, pseudoinclusions | Immunohistochemistry (Tyrogloubin) |
| salivary oncocytoma | Eosinophilic, non-serous cells | Hematoxylin |
| mucoepidermoid carcinoma | Microcystic, and follicula, inconspicuous mucous/squamoid cells, eosinophilic | Immunohistochemistry for p63 |
| Mammary analoge secretory carcinoma | Histologically similar | Lack of PAS-positive secretory granules, Vimentin positive, Adipophilin positive |
References
- ↑ "Tumors of the Salivary Glands, Atlas of Tumor Pathology: Third Series, Fascicle 17 G. L. Ellis and P. L. Auclair. Armed Forces Institute of Pathology, Washington D.C. ISBN: 1 881041 26 3 (Printed). 1996. Price: $69.00. ISBN: 1 881041 41 7 (CD-ROM). 1998. Price: $65.00". The Journal of Pathology. 192 (4): 564–565. 2000. doi:10.1002/1096-9896(200012)192:4<564::AID-PATH737>3.0.CO;2-M. ISSN 0022-3417.
- ↑ Kumar, Uma (2017). "Acinic Cell Carcinoma Papillary-Cystic Variant: Diagnostic Pitfalls in Fine Needle Aspiration Cytology". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH. doi:10.7860/JCDR/2017/21347.9772. ISSN 2249-782X.