Beriberi differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Differential Diagnosis

Beriberi should be differentiated from other causes of cardiac dysfunction (wet beriberi), peripheral neuropathy (dry beriberi), delirium (WKS), and other disorders caused by excessive alcohol drinking. However, the differential diagnosis is broad due to the non-specific symptoms of cardiac and neural involvement associated with the condition.

Disorders	Etiology	Clinical Presentation	Laboratory findings
Cardiomyopathy due to other causes as alcohol or DM
Delirium and delusional disorders
Depression
Nerve entrapment disorders
Alcoholic hepatitis	Chronic and excessive alcohol consumption	Poor appetite Fatigue Emesis Low grade fever Abdominal tenderness	Increased serum levels of ALT and AST Blood picture: Leukemoid reactions (high WBCs count) may be present. Liver US:
Diabetic ketoacidosis
Hyperthyroidism	Primary: Grave's disease, toxic thyroid nodules and adenoma Secondary: Pituitary adenomas and intracranial tumors Tertiary:Intracranial tumors involving the hypothalamus	Goiter Palpitations Anxiety Heat intolerance Insomnia Weight loss Diarrhea Exophthalmus	Elevated T3 and T4 hormones TSH: Reduced in 1ry and Elevated in 2ry hyperthyroidism. Thyroid stimulating antibodies: Elevated only in Grave's disease
Folic acid deficiency

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