Central pontine myelinolysis history and symptoms: Difference between revisions
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{{CMG}}; {{AE}} {{MMJ}} | {{CMG}}; {{AE}} {{MMJ}} | ||
==Overview== | ==Overview== | ||
<br /> | <br /> | ||
==History and Symptoms== | ==History and Symptoms== | ||
===History=== | ===History=== | ||
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===Common Symptoms=== | ===Common Symptoms=== | ||
Common symptoms of [disease] include: | Common symptoms of [disease] include: | ||
*[ | *Spastic [[quadriparesis]] | ||
*[ | *[[Dysarthria]] | ||
*[ | *[[Pseudobulbar palsy]] | ||
*[[Altered mental status]] | |||
* In some patients, parkinsonian features, behavioral manifestations, and [[neuropsychological]] symptoms can also be present: | |||
** [[Personality changes]] | |||
*[ | ** [[Labile affect]] | ||
*[ | ** [[Disinhibition]] | ||
*[ | ** Poor judgment | ||
** [[Delusional disorder|Paranoid delusions]] | |||
** [[Emotional lability]] | |||
** [[Delirium]] | |||
** [[Hallucinations]] | |||
** [[Catatonia]] | |||
==References== | ==References== | ||
Revision as of 00:25, 28 December 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
History and Symptoms
History
Patients with central pontine myelinolysis may have a positive history of:[1][2][3]
- Malnutrition
- Alcohol use disorder
- Chronic liver disease
- Hyperemesis gravidarum
- Hypophosphatemia secondary to refeeding syndrome
- Prolonged ischemia
These patients with central pontine myelinolysis most commonly have a history of rapid sodium correction, greater than 0.5-1.0 mEq/L per hour.
The most susceptible patients are those with:[1]
- Chronic hyponatremia (>48 hours)
- Severe hyponatremia (Na <120 mEq/L)
- Both Chronic hyponatremia and severe hyponatremia
Common Symptoms
Common symptoms of [disease] include:
- In some patients, parkinsonian features, behavioral manifestations, and neuropsychological symptoms can also be present:
References
- ↑ 1.0 1.1 "StatPearls". 2019. PMID 31869161.
- ↑ Seliger S, Kestenbaum B (2018). "Commentary on Treatment of Severe Hyponatremia". Clin J Am Soc Nephrol. 13 (4): 650–651. doi:10.2215/CJN.13381217. PMC 5969468. PMID 29295827.
- ↑ Yu J, Zheng SS, Liang TB, Shen Y, Wang WL, Ke QH (2004). "Possible causes of central pontine myelinolysis after liver transplantation". World J Gastroenterol. 10 (17): 2540–3. doi:10.3748/wjg.v10.i17.2540. PMC 4572157. PMID 15300900.