Central pontine myelinolysis history and symptoms: Difference between revisions
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===Common Symptoms=== | ===Common Symptoms=== | ||
Common symptoms of [disease] include:<ref name="pmid31869161">{{cite journal| author=| title=StatPearls | journal= | year= 2019 | volume= | issue= | pages= | pmid=31869161 | doi= | pmc= | url= }} </ref><ref name="pmid29295827">{{cite journal| author=Seliger S, Kestenbaum B| title=Commentary on Treatment of Severe Hyponatremia. | journal=Clin J Am Soc Nephrol | year= 2018 | volume= 13 | issue= 4 | pages= 650-651 | pmid=29295827 | doi=10.2215/CJN.13381217 | pmc=5969468 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29295827 }} </ref><ref name="pmid15300900">{{cite journal| author=Yu J, Zheng SS, Liang TB, Shen Y, Wang WL, Ke QH| title=Possible causes of central pontine myelinolysis after liver transplantation. | journal=World J Gastroenterol | year= 2004 | volume= 10 | issue= 17 | pages= 2540-3 | pmid=15300900 | doi=10.3748/wjg.v10.i17.2540 | pmc=4572157 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15300900 }} </ref><ref name=" | Common symptoms of [disease] include:<ref name="pmid31869161">{{cite journal| author=| title=StatPearls | journal= | year= 2019 | volume= | issue= | pages= | pmid=31869161 | doi= | pmc= | url= }} </ref><ref name="pmid29295827">{{cite journal| author=Seliger S, Kestenbaum B| title=Commentary on Treatment of Severe Hyponatremia. | journal=Clin J Am Soc Nephrol | year= 2018 | volume= 13 | issue= 4 | pages= 650-651 | pmid=29295827 | doi=10.2215/CJN.13381217 | pmc=5969468 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29295827 }} </ref><ref name="pmid15300900">{{cite journal| author=Yu J, Zheng SS, Liang TB, Shen Y, Wang WL, Ke QH| title=Possible causes of central pontine myelinolysis after liver transplantation. | journal=World J Gastroenterol | year= 2004 | volume= 10 | issue= 17 | pages= 2540-3 | pmid=15300900 | doi=10.3748/wjg.v10.i17.2540 | pmc=4572157 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15300900 }} </ref><ref name="pmid28392953" /> | ||
*Spastic [[quadriparesis]] | *Spastic [[quadriparesis]] | ||
*[[Dysarthria]] | *[[Dysarthria]] | ||
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* In some patients, parkinsonian features, behavioral manifestations, and [[neuropsychological]] symptoms can also be present:<ref name="pmid28392953">{{cite journal| author=Gopal M, Parasram M, Patel H, Ilorah C, Nersesyan H| title=Acute Psychosis as Main Manifestation of Central Pontine Myelinolysis. | journal=Case Rep Neurol Med | year= 2017 | volume= 2017 | issue= | pages= 1471096 | pmid=28392953 | doi=10.1155/2017/1471096 | pmc=5368399 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28392953 }} </ref> | * In some patients, parkinsonian features, behavioral manifestations, and [[neuropsychological]] symptoms can also be present:<ref name="pmid28392953">{{cite journal| author=Gopal M, Parasram M, Patel H, Ilorah C, Nersesyan H| title=Acute Psychosis as Main Manifestation of Central Pontine Myelinolysis. | journal=Case Rep Neurol Med | year= 2017 | volume= 2017 | issue= | pages= 1471096 | pmid=28392953 | doi=10.1155/2017/1471096 | pmc=5368399 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28392953 }} </ref> | ||
** [[Personality changes]] | **[[Personality changes]] | ||
** [[Labile affect]] | ** [[Labile affect]] | ||
** [[Disinhibition]] | ** [[Disinhibition]] | ||
Revision as of 18:14, 30 December 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
History and Symptoms
History
Patients with central pontine myelinolysis may have a positive history of:[1][2][3]
- Malnutrition
- Alcohol use disorder
- Chronic liver disease
- Hyperemesis gravidarum
- Hypophosphatemia secondary to refeeding syndrome
- Prolonged ischemia
These patients with central pontine myelinolysis most commonly have a history of rapid sodium correction, greater than 0.5-1.0 mEq/L per hour.
The most susceptible patients are those with:[1]
- Chronic hyponatremia (>48 hours)
- Severe hyponatremia (Na <120 mEq/L)
- Both Chronic hyponatremia and severe hyponatremia
Common Symptoms
Common symptoms of [disease] include:[1][2][3][4]
- In some patients, parkinsonian features, behavioral manifestations, and neuropsychological symptoms can also be present:[4]
References
- ↑ 1.0 1.1 1.2 "StatPearls". 2019. PMID 31869161.
- ↑ 2.0 2.1 Seliger S, Kestenbaum B (2018). "Commentary on Treatment of Severe Hyponatremia". Clin J Am Soc Nephrol. 13 (4): 650–651. doi:10.2215/CJN.13381217. PMC 5969468. PMID 29295827.
- ↑ 3.0 3.1 Yu J, Zheng SS, Liang TB, Shen Y, Wang WL, Ke QH (2004). "Possible causes of central pontine myelinolysis after liver transplantation". World J Gastroenterol. 10 (17): 2540–3. doi:10.3748/wjg.v10.i17.2540. PMC 4572157. PMID 15300900.
- ↑ 4.0 4.1 Gopal M, Parasram M, Patel H, Ilorah C, Nersesyan H (2017). "Acute Psychosis as Main Manifestation of Central Pontine Myelinolysis". Case Rep Neurol Med. 2017: 1471096. doi:10.1155/2017/1471096. PMC 5368399. PMID 28392953.