Rheumatic fever laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
===Inflammatory Markers=== | ===Inflammatory Markers=== | ||
Laboratory findings consistent with the diagnosis of rheumatic fever include: | |||
*[[Leukocytes]] | *[[Leukocytes]] | ||
*[[C-reactive protein]] | *[[C-reactive protein]] | ||
Revision as of 14:12, 18 February 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Varun Kumar, M.B.B.S. Anthony Gallo, B.S. [2]
Overview
Laboratory findings consistent with the diagnosis of rheumatic fever include elevated inflammatory markers, presence of streptococcal infection, and elevated or rising antistreptolysin O antibody titer.
Laboratory Findings
Inflammatory Markers
Laboratory findings consistent with the diagnosis of rheumatic fever include:
Throat Culture
Throat culture for group A beta-hemolytic streptococci may be performed. However many patients may have negative culture when rheumatic fever develops.[1]
Rapid Streptococcal Antigen
Rapid streptococcal antigen test may be performed. However, it has a lower sensitivity (70%) and statistically equal specificity (98%) as throat culture; a negative test results rules out streptococcal infection.[2]
Antistreptolysin O Antibody
Elevated or rising antistreptolysin O antibody titer is often noted. The antibodies usually peak approximately during fourth or fifth week after the onset of infection. Patients should be tested at intervals of two weeks to detect raising titers. Antistreptococcal antibodies may also be noted in patients who are streptococcal carriers with asymptomatic pharyngitis.
Leukocytosis
A marked leukocytosis is present.
C-Reactive Protein
An elevated C-reactive protein level is present.
Erythrocyte Sedimentation Rate
An elevated erythrocyte sedimentation rate is present.
Biopsy of Endocardium
Laboratory findings consistent with the diagnosis of [disease name] include:
- [Abnormal test 1]
- [Abnormal test 2]
- [Abnormal test 3]
References
- ↑ "Guidelines for the diagnosis of rheumatic fever. Jones Criteria, 1992 update. Special Writing Group of the Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the Council on Cardiovascular Disease in the Young of the American Heart Association". JAMA. 268 (15): 2069–73. 1992. PMID 1404745.
- ↑ Choby BA (2009). "Diagnosis and treatment of streptococcal pharyngitis". Am Fam Physician. 79 (5): 383–90. PMID 19275067.