HIV associated nephropathy surgery: Difference between revisions
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=== Kidney Transplantation === | === Kidney Transplantation === | ||
* Kidney transplantation in HIV positive patients with ESRD is increasing.<ref name="pmid29872351">{{cite journal| author=Palau L, Menez S, Rodriguez-Sanchez J, Novick T, Delsante M, McMahon BA | display-authors=etal| title=HIV-associated nephropathy: links, risks and management. | journal=HIV AIDS (Auckl) | year= 2018 | volume= 10 | issue= | pages= 73-81 | pmid=29872351 | doi=10.2147/HIV.S141978 | pmc=5975615 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29872351 }} </ref> | *[[Kidney transplantation]] in [[Human Immunodeficiency Virus (HIV)|HIV]]-positive patients with [[End-stage renal disease|end-stage renal disease (ESRD)]] is increasing.<ref name="pmid29872351">{{cite journal| author=Palau L, Menez S, Rodriguez-Sanchez J, Novick T, Delsante M, McMahon BA | display-authors=etal| title=HIV-associated nephropathy: links, risks and management. | journal=HIV AIDS (Auckl) | year= 2018 | volume= 10 | issue= | pages= 73-81 | pmid=29872351 | doi=10.2147/HIV.S141978 | pmc=5975615 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29872351 }} </ref> | ||
*A study reported | *A study reported a two to threefold increase in kidney rejection in patients with HIV-positive compared to HIV-negative.<ref name="pmid21083386">{{cite journal| author=Stock PG, Barin B, Murphy B, Hanto D, Diego JM, Light J | display-authors=etal| title=Outcomes of kidney transplantation in HIV-infected recipients. | journal=N Engl J Med | year= 2010 | volume= 363 | issue= 21 | pages= 2004-14 | pmid=21083386 | doi=10.1056/NEJMoa1001197 | pmc=3028983 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21083386 }} </ref>. | ||
* | *In one study the incidence of rejection was 31% and 41% at 1 and 3 years, respectively.<ref name="pmid21083386" /> In another study the acute rejection rate was 18% and 27% at 1 and 3 years, respectively.<ref name="pmid26061701">{{cite journal| author=Waheed S, Sakr A, Chheda ND, Lucas GM, Estrella M, Fine DM | display-authors=etal| title=Outcomes of Renal Transplantation in HIV-1 Associated Nephropathy. | journal=PLoS One | year= 2015 | volume= 10 | issue= 6 | pages= e0129702 | pmid=26061701 | doi=10.1371/journal.pone.0129702 | pmc=4463848 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26061701 }} </ref> | ||
*The high rejection rate require more effective [[immunotherapy]].<ref name="pmid21083386" /> | |||
*[[Graft]] survival rates were 90.4% and 73.7% at 1 and 3 years,<ref name="pmid21083386" /> respectively in one study and 100% and 81%, respectively in another study.<ref name="pmid26061701" /> | |||
*While HIV-negative donor to HIV-positive recipient kidney transplantation has been carried out since 2001 60 | |||
*the concerns regarding HIV-positive to HIV-positive transplantation include HIV superinfection, resistance to cART and potential recurrence of HIVAN, in addition to inferior outcomes in general.60 | |||
*Recently, there have been reports from USA and South Africa that have shown successful kidney transplantation from HIV-positive donors to HIV-positive recipients. | |||
==References== | ==References== | ||
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Overview
HIV Associated Nephropathy Surgery
Kidney Transplantation
- Kidney transplantation in HIV-positive patients with end-stage renal disease (ESRD) is increasing.[1]
- A study reported a two to threefold increase in kidney rejection in patients with HIV-positive compared to HIV-negative.[2].
- In one study the incidence of rejection was 31% and 41% at 1 and 3 years, respectively.[2] In another study the acute rejection rate was 18% and 27% at 1 and 3 years, respectively.[3]
- The high rejection rate require more effective immunotherapy.[2]
- Graft survival rates were 90.4% and 73.7% at 1 and 3 years,[2] respectively in one study and 100% and 81%, respectively in another study.[3]
- While HIV-negative donor to HIV-positive recipient kidney transplantation has been carried out since 2001 60
- the concerns regarding HIV-positive to HIV-positive transplantation include HIV superinfection, resistance to cART and potential recurrence of HIVAN, in addition to inferior outcomes in general.60
- Recently, there have been reports from USA and South Africa that have shown successful kidney transplantation from HIV-positive donors to HIV-positive recipients.
References
- ↑ Palau L, Menez S, Rodriguez-Sanchez J, Novick T, Delsante M, McMahon BA; et al. (2018). "HIV-associated nephropathy: links, risks and management". HIV AIDS (Auckl). 10: 73–81. doi:10.2147/HIV.S141978. PMC 5975615. PMID 29872351.
- ↑ 2.0 2.1 2.2 2.3 Stock PG, Barin B, Murphy B, Hanto D, Diego JM, Light J; et al. (2010). "Outcomes of kidney transplantation in HIV-infected recipients". N Engl J Med. 363 (21): 2004–14. doi:10.1056/NEJMoa1001197. PMC 3028983. PMID 21083386.
- ↑ 3.0 3.1 Waheed S, Sakr A, Chheda ND, Lucas GM, Estrella M, Fine DM; et al. (2015). "Outcomes of Renal Transplantation in HIV-1 Associated Nephropathy". PLoS One. 10 (6): e0129702. doi:10.1371/journal.pone.0129702. PMC 4463848. PMID 26061701.