HIV associated nephropathy surgery: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{HIV associated nephropathy}} | {{HIV associated nephropathy}} | ||
{{CMG}} {{AE}} {{SHA}} | |||
== Overview == | == Overview == | ||
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*The high rejection rate require more effective [[immunotherapy]].<ref name="pmid21083386" /> | *The high rejection rate require more effective [[immunotherapy]].<ref name="pmid21083386" /> | ||
*[[Graft]] survival rates were 90.4% and 73.7% at 1 and 3 years,<ref name="pmid21083386" /> respectively in one study and 100% and 81%, respectively in another study.<ref name="pmid26061701" /> | *[[Graft]] survival rates were 90.4% and 73.7% at 1 and 3 years,<ref name="pmid21083386" /> respectively in one study and 100% and 81%, respectively in another study.<ref name="pmid26061701" /> | ||
*the concerns regarding HIV-positive to HIV-positive transplantation include HIV superinfection, resistance to cART and potential recurrence of HIVAN, in addition to inferior outcomes in general.60 | *the concerns regarding HIV-positive to HIV-positive transplantation include HIV superinfection, resistance to cART and potential recurrence of HIVAN, in addition to inferior outcomes in general.60 | ||
*Recently, there have been reports | *Recently, there have been reports of successful kidney transplantation from HIV-positive donors to HIV-positive recipients.<ref name="pmid25671253">{{cite journal| author=Muller E, Barday Z, Mendelson M, Kahn D| title=HIV-positive-to-HIV-positive kidney transplantation--results at 3 to 5 years. | journal=N Engl J Med | year= 2015 | volume= 372 | issue= 7 | pages= 613-20 | pmid=25671253 | doi=10.1056/NEJMoa1408896 | pmc=5090019 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25671253 }} </ref><ref name="pmid27043422">{{cite journal| author=Durand CM, Segev D, Sugarman J| title=Realizing HOPE: The Ethics of Organ Transplantation From HIV-Positive Donors. | journal=Ann Intern Med | year= 2016 | volume= 165 | issue= 2 | pages= 138-42 | pmid=27043422 | doi=10.7326/M16-0560 | pmc=4949150 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27043422 }} </ref> | ||
* HIV superinfection and resistance to cART are among the most concerning risks in kidney transplantation in HIV-positive kidneys to HIV-positive recipients | |||
==References== | ==References== | ||
Revision as of 04:03, 26 June 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
HIV Associated Nephropathy Surgery
Kidney Transplantation
- Kidney transplantation in HIV-positive patients with end-stage renal disease (ESRD) is increasing.[1]
- A study reported a two to threefold increase in kidney rejection in patients with HIV-positive compared to HIV-negative.[2].
- In one study the incidence of rejection was 31% and 41% at 1 and 3 years, respectively.[2] In another study the acute rejection rate was 18% and 27% at 1 and 3 years, respectively.[3]
- The high rejection rate require more effective immunotherapy.[2]
- Graft survival rates were 90.4% and 73.7% at 1 and 3 years,[2] respectively in one study and 100% and 81%, respectively in another study.[3]
- the concerns regarding HIV-positive to HIV-positive transplantation include HIV superinfection, resistance to cART and potential recurrence of HIVAN, in addition to inferior outcomes in general.60
- Recently, there have been reports of successful kidney transplantation from HIV-positive donors to HIV-positive recipients.[4][5]
- HIV superinfection and resistance to cART are among the most concerning risks in kidney transplantation in HIV-positive kidneys to HIV-positive recipients
References
- ↑ Palau L, Menez S, Rodriguez-Sanchez J, Novick T, Delsante M, McMahon BA; et al. (2018). "HIV-associated nephropathy: links, risks and management". HIV AIDS (Auckl). 10: 73–81. doi:10.2147/HIV.S141978. PMC 5975615. PMID 29872351.
- ↑ 2.0 2.1 2.2 2.3 Stock PG, Barin B, Murphy B, Hanto D, Diego JM, Light J; et al. (2010). "Outcomes of kidney transplantation in HIV-infected recipients". N Engl J Med. 363 (21): 2004–14. doi:10.1056/NEJMoa1001197. PMC 3028983. PMID 21083386.
- ↑ 3.0 3.1 Waheed S, Sakr A, Chheda ND, Lucas GM, Estrella M, Fine DM; et al. (2015). "Outcomes of Renal Transplantation in HIV-1 Associated Nephropathy". PLoS One. 10 (6): e0129702. doi:10.1371/journal.pone.0129702. PMC 4463848. PMID 26061701.
- ↑ Muller E, Barday Z, Mendelson M, Kahn D (2015). "HIV-positive-to-HIV-positive kidney transplantation--results at 3 to 5 years". N Engl J Med. 372 (7): 613–20. doi:10.1056/NEJMoa1408896. PMC 5090019. PMID 25671253.
- ↑ Durand CM, Segev D, Sugarman J (2016). "Realizing HOPE: The Ethics of Organ Transplantation From HIV-Positive Donors". Ann Intern Med. 165 (2): 138–42. doi:10.7326/M16-0560. PMC 4949150. PMID 27043422.