Heart transplantation risk factors: Difference between revisions

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==Risk Factors==
==Risk Factors==
There are no established risk factors for [disease name].


OR
Risk factors for poor outcome post-transplantation can be due to donor-specific characteristics, recipient-specific characteristics, and risk factors due to interactions between the donor and recipient.


The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].
===Recipient factors===
* Use of total artificial heart as a bridge to transplant or a need for end-organ support in the form of [[mechanical ventilation]] or [[dialysis]]- associated with the greatest one-year mortality
* Best prognosis is seen if the indication for transplant is [[ischemic]] and [[nonischemic cardiomyopathy]] <ref name="KhushCherikh2018">{{cite journal|last1=Khush|first1=Kiran K.|last2=Cherikh|first2=Wida S.|last3=Chambers|first3=Daniel C.|last4=Goldfarb|first4=Samuel|last5=Hayes|first5=Don|last6=Kucheryavaya|first6=Anna Y.|last7=Levvey|first7=Bronwyn J.|last8=Meiser|first8=Bruno|last9=Rossano|first9=Joseph W.|last10=Stehlik|first10=Josef|title=The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth Adult Heart Transplantation Report—2018; Focus Theme: Multiorgan Transplantation|journal=The Journal of Heart and Lung Transplantation|volume=37|issue=10|year=2018|pages=1155–1168|issn=10532498|doi=10.1016/j.healun.2018.07.022}}</ref>


OR
* Patients with a history of [[congenital heart disease]], [[restrictive cardiomyopathy]], and those undergoing retransplantation have a worse prognosis.
* Younger recipients (below age 55) have an advantage
* Pre-transplant serum [[creatinine]] and total [[bilirubin]] are linearly related to survival.


Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
Some other risk factors are:
===Common Risk Factors===
* Use of [[Amiodarone]] pretransplantation
*Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.
* Hypertension
*Common risk factors in the development of [disease name] include:
* Hypercholesterolemia
**[Risk factor 1]
* Diabetes
**[Risk factor 2]
* Renal insufficiency
**[Risk factor 3]
* Use of specific immunosuppressive regimen
* Elevated body mass index
* Tobacco use
* Obesity
* Early post-transplant complications
* Prior cardiac surgery
* Transplantation of a female heart into a male or female recipient


===Less Common Risk Factors===
Post-transplant survival has improved over time.
*Less common risk factors in the development of [disease name] include:
The median survival after adult heart transplants performed between 2002 and 2009 is 12.5 years, which extends to 14.8 years among 1-year survivors. <ref name="pmid31548031">{{cite journal| author=Khush KK, Cherikh WS, Chambers DC, Harhay MO, Hayes D, Hsich E | display-authors=etal| title=The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report - 2019; focus theme: Donor and recipient size match. | journal=J Heart Lung Transplant | year= 2019 | volume= 38 | issue= 10 | pages= 1056-1066 | pmid=31548031 | doi=10.1016/j.healun.2019.08.004 | pmc=6816343 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31548031  }} </ref>
**[Risk factor 1]
 
**[Risk factor 2]
Tony Huesman was the world's longest-living heart transplant patient, having survived for 28 years with a transplanted heart. Huesman received a heart transplant in 1978 at Stanford University under American heart transplant pioneer [[Norman Shumway|Dr. Norman Shumway]], <ref>[http://www.cbsnews.com/stories/2006/09/14/ap/health/mainD8K49NG86.shtml Heart Transplant Patient OK After 28 Yrs] (September 14, 2006) ''CBS News''. Retrieved December 29, 2006.</ref>
**[Risk factor 3]


==References==
==References==

Revision as of 11:17, 26 June 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

There are no established risk factors that lead to cardiac transplantation. Cardiac transplant is the end result of heart failure and the common risk factors in the development of heart failure include hypertension, diabetes, coronary disease, and obesity.

Risk Factors

Risk factors for poor outcome post-transplantation can be due to donor-specific characteristics, recipient-specific characteristics, and risk factors due to interactions between the donor and recipient.

Recipient factors

Some other risk factors are:

  • Use of Amiodarone pretransplantation
  • Hypertension
  • Hypercholesterolemia
  • Diabetes
  • Renal insufficiency
  • Use of specific immunosuppressive regimen
  • Elevated body mass index
  • Tobacco use
  • Obesity
  • Early post-transplant complications
  • Prior cardiac surgery
  • Transplantation of a female heart into a male or female recipient

Post-transplant survival has improved over time. The median survival after adult heart transplants performed between 2002 and 2009 is 12.5 years, which extends to 14.8 years among 1-year survivors. [2]

Tony Huesman was the world's longest-living heart transplant patient, having survived for 28 years with a transplanted heart. Huesman received a heart transplant in 1978 at Stanford University under American heart transplant pioneer Dr. Norman Shumway, [3]

References

  1. ↑ Khush, Kiran K.; Cherikh, Wida S.; Chambers, Daniel C.; Goldfarb, Samuel; Hayes, Don; Kucheryavaya, Anna Y.; Levvey, Bronwyn J.; Meiser, Bruno; Rossano, Joseph W.; Stehlik, Josef (2018). "The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth Adult Heart Transplantation Report—2018; Focus Theme: Multiorgan Transplantation". The Journal of Heart and Lung Transplantation. 37 (10): 1155–1168. doi:10.1016/j.healun.2018.07.022. ISSN 1053-2498.
  2. ↑ Khush KK, Cherikh WS, Chambers DC, Harhay MO, Hayes D, Hsich E; et al. (2019). "The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report - 2019; focus theme: Donor and recipient size match". J Heart Lung Transplant. 38 (10): 1056–1066. doi:10.1016/j.healun.2019.08.004. PMC 6816343 Check |pmc= value (help). PMID 31548031.
  3. ↑ Heart Transplant Patient OK After 28 Yrs (September 14, 2006) CBS News. Retrieved December 29, 2006.

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