Analgesic nephropathy causes: Difference between revisions
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=== NSAIDs, aspirin and acetaminophen === | === NSAIDs, aspirin and acetaminophen === | ||
* Although non-phenacetin [[Analgesic|analgesics]] (such as [[Non-steroidal anti-inflammatory drug|NSAIDs]], [[aspirin]] and [[acetaminophen]]) have been reported in some studies as causes to analgesic nephropathy, but there is insufficient evidence that suggest these drugs cause analgesic nephropathy.<ref name=" | * Although combinations of non-phenacetin [[Analgesic|analgesics]] (such as [[Non-steroidal anti-inflammatory drug|NSAIDs]], [[aspirin]] and [[acetaminophen]]) have been reported in some studies as causes to analgesic nephropathy, but there is insufficient evidence that suggest these drugs cause analgesic nephropathy.<ref name="pmid11115060">{{cite journal| author=Feinstein AR, Heinemann LA, Curhan GC, Delzell E, Deschepper PJ, Fox JM | display-authors=etal| title=Relationship between nonphenacetin combined analgesics and nephropathy: a review. Ad Hoc Committee of the International Study Group on Analgesics and Nephropathy. | journal=Kidney Int | year= 2000 | volume= 58 | issue= 6 | pages= 2259-64 | pmid=11115060 | doi=10.1046/j.1523-1755.2000.00410.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11115060 }} </ref><ref name="pmid9556702">{{cite journal| author=Delzell E, Shapiro S| title=A review of epidemiologic studies of nonnarcotic analgesics and chronic renal disease. | journal=Medicine (Baltimore) | year= 1998 | volume= 77 | issue= 2 | pages= 102-21 | pmid=9556702 | doi=10.1097/00005792-199803000-00003 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9556702 }} </ref> | ||
* Further randomized trials are required to assess the incidence of renal injury and analgesic nephropathy caused by certain drugs.<ref name="pmid27900067" /> | * Further randomized trials are required to assess the incidence of renal injury and analgesic nephropathy caused by certain drugs.<ref name="pmid27900067" /> | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Shakiba Hassanzadeh, MD[2]
Overview
There is a strong association between phenacetin and analgesic nephropathy which has led to the disappearing of classic analgesic nephropathy after the removal of phenacetin from the markets over 30 years ago. Although non-phenacetin analgesics (such as NSAIDs, aspirin and acetaminophen) have been reported in some studies as causes to analgesic nephropathy, but there is insufficient evidence that suggest these drugs cause analgesic nephropathy.
Causes
Phenacetin
- There is a strong association between phenacetin and analgesic nephropathy.[1]
- The classic analgesic nephropathy is disappearing after the removal of phenacetin from the markets over 30 years ago.[2]
NSAIDs, aspirin and acetaminophen
- Although combinations of non-phenacetin analgesics (such as NSAIDs, aspirin and acetaminophen) have been reported in some studies as causes to analgesic nephropathy, but there is insufficient evidence that suggest these drugs cause analgesic nephropathy.[3][4]
- Further randomized trials are required to assess the incidence of renal injury and analgesic nephropathy caused by certain drugs.[1]
References
- ↑ 1.0 1.1 Yaxley J (2016). "Common Analgesic Agents and Their Roles in Analgesic Nephropathy: A Commentary on the Evidence". Korean J Fam Med. 37 (6): 310–316. doi:10.4082/kjfm.2016.37.6.310. PMC 5122661. PMID 27900067.
- ↑ Mihatsch MJ, Khanlari B, Brunner FP (2006). "Obituary to analgesic nephropathy--an autopsy study". Nephrol Dial Transplant. 21 (11): 3139–45. doi:10.1093/ndt/gfl390. PMID 16891638.
- ↑ Feinstein AR, Heinemann LA, Curhan GC, Delzell E, Deschepper PJ, Fox JM; et al. (2000). "Relationship between nonphenacetin combined analgesics and nephropathy: a review. Ad Hoc Committee of the International Study Group on Analgesics and Nephropathy". Kidney Int. 58 (6): 2259–64. doi:10.1046/j.1523-1755.2000.00410.x. PMID 11115060.
- ↑ Delzell E, Shapiro S (1998). "A review of epidemiologic studies of nonnarcotic analgesics and chronic renal disease". Medicine (Baltimore). 77 (2): 102–21. doi:10.1097/00005792-199803000-00003. PMID 9556702.