Catecholaminergic polymorphic ventricular tachycardia overview: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
Catecholaminergic polymorphic ventricular tachycardia is caused by [[mutations]] in [[genes]] encoding [[voltage-gated ion channel|channel proteins]] that regulate the [[cardiac]] electrical function, resulting in inappropriate [[calcium]] leak from the [[sarcoplasmic reticulum]] during electrical [[diastole]] and thus leading to triggered [[arrhythmias]], in the absence of structural [[cardiac]] abnormalities. [[CPVT]] is thus an inherited disorder and may have both [[autosomal dominant]] and [[autosomal recessive]] pattern of [[inheritance]]. [[Genes]] associated with [[CPVT]] include [[ryanodine receptor 2|RYR2]], [[Calsequestrin|CASQ2]], [[Calmodulin 1|CALM1]] and [[TRDN]]. | |||
==[[Catecholaminergic polymorphic ventricular tachycardia causes|Causes]]== | ==[[Catecholaminergic polymorphic ventricular tachycardia causes|Causes]]== | ||
Revision as of 07:14, 23 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) is a rare inherited arrhythmogenic disorder characterized by syncopal attacks, ventricular arrhythmias, and even sudden cardiac death, mostly in young patients. It is caused by mutations in calcium handling proteins such as RyR2 and CASQ2 within the sarcoplasmic reticulum, which results in ventricular arrhythmias in the setting of a high adrenergic tone such as during physical exercise or strong emotions. There are no associated structural abnormalities of the heart.
Historical Perspective
Catecholaminergic polymorphic ventricular tachycardia (CPVT) was first described by Reid et al in 1975. It was described as a familial cardiac arrhythmia that occurs in patients with structurally normal heart and causes exercise or emotion triggered syncope and sudden death with a distinguishing pattern of ventricular and supraventricular arrhythmias. In 2001, cardiac ryanodine receptor gene (RyR2) mutations were first implicated in the pathogenesis of catecholaminergic polymorphic ventricular tachycardia (CPVT). Subsequent experimental studies demonstrated that the abnormal calcium release from the sarcoplasmic reticulum caused arrhythmias mediated by delayed afterdepolarizations and triggered activity.
Classification
Catecholaminergic polymorphic ventricular tachycardia can be classified based upon the underlying pathogenic mutation.
Pathophysiology
Catecholaminergic polymorphic ventricular tachycardia is caused by mutations in genes encoding channel proteins that regulate the cardiac electrical function, resulting in inappropriate calcium leak from the sarcoplasmic reticulum during electrical diastole and thus leading to triggered arrhythmias, in the absence of structural cardiac abnormalities. CPVT is thus an inherited disorder and may have both autosomal dominant and autosomal recessive pattern of inheritance. Genes associated with CPVT include RYR2, CASQ2, CALM1 and TRDN.
Causes
Differentiating Catecholaminergic polymorphic ventricular tachycardia from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic study of choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X-Ray Findings | Echocardiography and Ultrasound | CT-Scan Findings | MRI Findings | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Interventions | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies