Dysfunctional uterine bleeding laboratory findings: Difference between revisions
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{{Dysfunctional uterine bleeding}} | {{Dysfunctional uterine bleeding}} | ||
{{CMG}} {{AE}} {{VVS}} | {{CMG}} {{AE}} [[User:AroojNaz|Arooj Naz]], {{VVS}} | ||
== Laboratory Findings == | |||
* Pap smear | == Overview == | ||
* Peripheral smear | Women afflicted with dysfunctional uterine bleeding commonly present with CBC changes, particularly changes in red blood cells. Significant laboratory findings may include coagulation profile changes, genitourinary findings, hormonal levels as well as biomedical markers to detect underlying malignancies. | ||
==Laboratory Findings== | |||
A pregnancy test should be done to rule out pregnancy related complications leading to dysfunctional uterine bleeding by testing for [[human chorionic gonadotropin]].<ref name="pmid30422508">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume= | issue= | pages= | pmid=30422508 | doi= | pmc= | url= }}</ref> | |||
==== CBC<ref name="pmid304225082">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume= | issue= | pages= | pmid=30422508 | doi= | pmc= | url= }}</ref> ==== | |||
# [[RBC]]: Iron deficiency anemia may be seen; Microcytic, hypochromic anemia with central pallor and target like cells | |||
# [[WBC]]: [[leukocytosis]]: normal | |||
# [[Platelets]]: changes in platelet count may be seen if coagulopathy is the underlying cause | |||
'''[[Coagulation|Coagulation Profile]]'''<ref name="pmid32491756">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume= | issue= | pages= | pmid=32491756 | doi= | pmc= | url= }}</ref> | |||
* [[Platelets]]: changes in platelet count may be seen if coagulopathy is the underlying cause | |||
* [[PT]], [[aPTT]] and [[bleeding time]] vary depending on the underlying [[coagulopathy]] | |||
* Normal labs indicate a lack of bleeding disorders as the underlying cause of DUB | |||
* [[Clotting factor]] assays | |||
'''[[Electrolyte|Electrolytes]]''' | |||
* no significant changes | |||
'''[[Genitourinary]] Tests''' | |||
*[[Pap smear]] | |||
*[[Peripheral smear]] | |||
=== [[Hormone|Hormonal Levels]] === | |||
* [[TSH]] | |||
* [[Prolactin]] | * [[Prolactin]] | ||
* [[Dehydroepiandrosterone-sulfate]] ([[DHEA-S]]) | |||
*[[Testosterone]] | |||
* [[Dehydroepiandrosterone-sulfate]] ([[DHEA-S]]) | *[[Estradiol]] | ||
* [[Testosterone]] | *[[Follicle stimulating hormone]] ([[FSH]]) | ||
* [[Estradiol]] | *[[Luteinizing hormone]] ([[LH]]) | ||
* [[Follicle stimulating hormone]] ([[FSH]]) | *Serum [[progesterone]] | ||
* [[Luteinizing hormone]] ([[LH]]) | |||
* [[ | === Biomedical Markers<ref name="pmid32965984">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume= | issue= | pages= | pmid=32965984 | doi= | pmc= | url= }}</ref> === | ||
* [[ | Markers may be helpful in diagnosing an underlying endometrial malignancy. These include: | ||
* | * [[Carbohydrate antigen 125]] (CA 125) | ||
* [[Estrogen and progesterone receptor]] expression | |||
* Presence of [[mutations]] (e.g., [[PTEN (gene)|PTEN]], [[TP53]]) | |||
* [[E-cadherin]] (CDH1) | |||
* Neural cell adhesion molecule L1 ([[L1CAM]]) | |||
<br /> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 08:33, 9 March 2022
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Dysfunctional uterine bleeding Microchapters |
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Differentiating Dysfunctional uterine bleeding from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Dysfunctional uterine bleeding laboratory findings On the Web |
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American Roentgen Ray Society Images of Dysfunctional uterine bleeding laboratory findings |
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Dysfunctional uterine bleeding laboratory findings in the news |
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Directions to Hospitals Treating Dysfunctional uterine bleeding |
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Risk calculators and risk factors for Dysfunctional uterine bleeding laboratory findings |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Arooj Naz, Vishnu Vardhan Serla M.B.B.S. [2]
Overview
Women afflicted with dysfunctional uterine bleeding commonly present with CBC changes, particularly changes in red blood cells. Significant laboratory findings may include coagulation profile changes, genitourinary findings, hormonal levels as well as biomedical markers to detect underlying malignancies.
Laboratory Findings
A pregnancy test should be done to rule out pregnancy related complications leading to dysfunctional uterine bleeding by testing for human chorionic gonadotropin.[1]
CBC[2]
- RBC: Iron deficiency anemia may be seen; Microcytic, hypochromic anemia with central pallor and target like cells
- WBC: leukocytosis: normal
- Platelets: changes in platelet count may be seen if coagulopathy is the underlying cause
- Platelets: changes in platelet count may be seen if coagulopathy is the underlying cause
- PT, aPTT and bleeding time vary depending on the underlying coagulopathy
- Normal labs indicate a lack of bleeding disorders as the underlying cause of DUB
- Clotting factor assays
- no significant changes
Genitourinary Tests
Hormonal Levels
- TSH
- Prolactin
- Dehydroepiandrosterone-sulfate (DHEA-S)
- Testosterone
- Estradiol
- Follicle stimulating hormone (FSH)
- Luteinizing hormone (LH)
- Serum progesterone
Biomedical Markers[4]
Markers may be helpful in diagnosing an underlying endometrial malignancy. These include:
- Carbohydrate antigen 125 (CA 125)
- Estrogen and progesterone receptor expression
- Presence of mutations (e.g., PTEN, TP53)
- E-cadherin (CDH1)
- Neural cell adhesion molecule L1 (L1CAM)