Reperfusion injury natural history: Difference between revisions
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{{Reperfusion injury}} | {{Reperfusion injury}} | ||
'''Editors-In-Chief:''' {{AC}}; [[C. Michael Gibson]], M.S., M.D. [mailto:Mgibson@perfuse.org]; [[User:Shivam Singla|Dr. Shivam Singla M.D. [2]]] '''Associate Editors-In-Chief: '''[[User:Kashish Goel|Kashish Goel, M.D ;]] | '''Editors-In-Chief:''' {{AC}}; [[C. Michael Gibson]], M.S., M.D. [mailto:Mgibson@perfuse.org]; [[User:Shivam Singla|Dr. Shivam Singla M.D. [2]]] '''Associate Editors-In-Chief: '''[[User:Kashish Goel|Kashish Goel, M.D ;]] | ||
== | ==Complications== | ||
* [[Myocardial stunning]]: Delayed recovery, usually 2-3 days, of the viable myocardium after reperfusion is termed as "myocardial stunning". It is mainly due to the release of reactive oxygen species and intracellular calcium overload. | * [[Myocardial stunning]]: Delayed recovery, usually 2-3 days, of the viable myocardium after reperfusion is termed as "myocardial stunning". It is mainly due to the release of reactive oxygen species and intracellular calcium overload. | ||
* [[Myocardial infarction]]: Irreversible myocyte cell death secondary to reduced oxygen delivery for more than 20-30 minutes, will lead to infarction. Reperfusion helps prevent complete loss of the involved area, however oxidative stress due to this may prevent complete resolution. | * [[Myocardial infarction]]: Irreversible myocyte cell death secondary to reduced oxygen delivery for more than 20-30 minutes, will lead to infarction. Reperfusion helps prevent complete loss of the involved area, however oxidative stress due to this may prevent complete resolution. | ||
* Acute [[heart failure]]: Loss of myocardial contractility and systolic dysfunction associated with ischemia/reperfusion injury may lead to development of acute heart failure. Early reperfusion in the course of [[STEMI]] prevents myocardial necrosis and may lead to complete recovery of function. | * Acute [[heart failure]]: Loss of myocardial contractility and systolic dysfunction associated with ischemia/reperfusion injury may lead to development of acute heart failure. Early reperfusion in the course of [[STEMI]] prevents myocardial necrosis and may lead to complete recovery of function. | ||
* [[Ventricular arrhythmia]]s: Reperfusion of the blocked coronary artery can also precipitate arrhythmias ranging from [[ventricular premature beat]]s to life-threatening [[ventricular fibrillation]]. | * [[Ventricular arrhythmia]]s: Reperfusion of the blocked coronary artery can also precipitate arrhythmias ranging from [[ventricular premature beat]]s to life-threatening [[ventricular fibrillation]]. | ||
== Prognosis == | |||
==References== | ==References== | ||
Revision as of 02:44, 13 August 2020
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Editors-In-Chief: Anjan K. Chakrabarti, M.D. [1]; C. Michael Gibson, M.S., M.D. [2]; Dr. Shivam Singla M.D. [2] Associate Editors-In-Chief: Kashish Goel, M.D ;
Complications
- Myocardial stunning: Delayed recovery, usually 2-3 days, of the viable myocardium after reperfusion is termed as "myocardial stunning". It is mainly due to the release of reactive oxygen species and intracellular calcium overload.
- Myocardial infarction: Irreversible myocyte cell death secondary to reduced oxygen delivery for more than 20-30 minutes, will lead to infarction. Reperfusion helps prevent complete loss of the involved area, however oxidative stress due to this may prevent complete resolution.
- Acute heart failure: Loss of myocardial contractility and systolic dysfunction associated with ischemia/reperfusion injury may lead to development of acute heart failure. Early reperfusion in the course of STEMI prevents myocardial necrosis and may lead to complete recovery of function.
- Ventricular arrhythmias: Reperfusion of the blocked coronary artery can also precipitate arrhythmias ranging from ventricular premature beats to life-threatening ventricular fibrillation.