Polycythemia risk factors: Difference between revisions
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==Risk Factors== | ==Risk Factors== | ||
*One of the most common and most dangerous complications of polycythemia vera is thrombus formation. The risk factors are as follows: | |||
*Women- usually younger at the time of diagnosis, have a higher risk of arterio-venous thrombosis. | |||
*Mutation- higher burden of JAK2V617F allele | |||
*Inflammatory markers- Pentraxins play an important role: increased hs-CRP and a lower PTX3 have a higher risk of thrombosis | |||
*Presence of microparticles- responsible for decreased thrombin inhibition, increased CD41, and an increased chance of splenomegaly | |||
*Neutrophil Extracellular Trap formations- NETosis and apoptosis <ref name="url[Full text] Polycythemia Vera-Associated Complications: Pathogenesis, Clinical Man | JBM">{{cite web |url=https://www.dovepress.com/polycythemia-vera-associated-complications-pathogenesis-clinical-manif-peer-reviewed-fulltext-article-JBM |title=[Full text] Polycythemia Vera-Associated Complications: Pathogenesis, Clinical Man | JBM |format= |work= |accessdate=}}</ref> | |||
==References== | ==References== | ||
Revision as of 01:00, 10 December 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]
Overview
There are no established risk factors for [disease name].
OR
The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].
OR
Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
OR
Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.
Risk Factors
- One of the most common and most dangerous complications of polycythemia vera is thrombus formation. The risk factors are as follows:
- Women- usually younger at the time of diagnosis, have a higher risk of arterio-venous thrombosis.
- Mutation- higher burden of JAK2V617F allele
- Inflammatory markers- Pentraxins play an important role: increased hs-CRP and a lower PTX3 have a higher risk of thrombosis
- Presence of microparticles- responsible for decreased thrombin inhibition, increased CD41, and an increased chance of splenomegaly
- Neutrophil Extracellular Trap formations- NETosis and apoptosis [1]