Pre-eclampsia pathophysiology: Difference between revisions
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{{CMG}}; {{AE}} {{Sara.Zand}} {{Ochuko}} | {{CMG}}; {{AE}} {{Sara.Zand}} {{Ochuko}} | ||
==Overview== | |||
==Pathophysiology== | ==Pathophysiology== | ||
* The pathogenesis of [[preeclampsia]] is characterized by the following :<ref name="JohansenRedman1999">{{cite journal|last1=Johansen|first1=M|last2=Redman|first2=C.W.G|last3=Wilkins|first3=T|last4=Sargent|first4=I.L|title=Trophoblast Deportation in Human Pregnancy—its Relevance for Pre-eclampsia|journal=Placenta|volume=20|issue=7|year=1999|pages=531–539|issn=01434004|doi=10.1053/plac.1999.0422}}</ref> | * The pathogenesis of [[preeclampsia]] is characterized by the following :<ref name="JohansenRedman1999">{{cite journal|last1=Johansen|first1=M|last2=Redman|first2=C.W.G|last3=Wilkins|first3=T|last4=Sargent|first4=I.L|title=Trophoblast Deportation in Human Pregnancy—its Relevance for Pre-eclampsia|journal=Placenta|volume=20|issue=7|year=1999|pages=531–539|issn=01434004|doi=10.1053/plac.1999.0422}}</ref> | ||
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[[Category:Emergency medicine]] | [[Category:Emergency medicine]] | ||
[[Category:Cardiology]] | [[Category:Cardiology]] | ||
Revision as of 02:18, 25 October 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Zand, M.D.[2] Ogheneochuko Ajari, MB.BS, MS [3]
Overview
Pathophysiology
- The pathogenesis of preeclampsia is characterized by the following :[1]
- Chronic uteroplacental ischemia[2]
- Genetic susceptibility
- very-low-density lipoprotein toxicity
- Increased trophoblast apoptosis or necrosis[3]
- Increased Maternal inflammatory response to fetal trophoblast
- Imbalance of angiogenic factors [4]
- Imbalance of prostacycline and thromboxan-A2
References
- ↑ Johansen, M; Redman, C.W.G; Wilkins, T; Sargent, I.L (1999). "Trophoblast Deportation in Human Pregnancy—its Relevance for Pre-eclampsia". Placenta. 20 (7): 531–539. doi:10.1053/plac.1999.0422. ISSN 0143-4004.
- ↑ Espinoza, J. (2012). "Uteroplacental ischemia in early- and late-onset pre-eclampsia: a role for the fetus?". Ultrasound in Obstetrics & Gynecology. 40 (4): 373–382. doi:10.1002/uog.12280. ISSN 0960-7692.
- ↑ Crocker, Ian P.; Cooper, Suzanne; Ong, Stephen C.; Baker, Philip N. (2003). "Differences in Apoptotic Susceptibility of Cytotrophoblasts and Syncytiotrophoblasts in Normal Pregnancy to Those Complicated with Preeclampsia and Intrauterine Growth Restriction". The American Journal of Pathology. 162 (2): 637–643. doi:10.1016/S0002-9440(10)63857-6. ISSN 0002-9440.
- ↑ Levine, Richard J.; Maynard, Sharon E.; Qian, Cong; Lim, Kee-Hak; England, Lucinda J.; Yu, Kai F.; Schisterman, Enrique F.; Thadhani, Ravi; Sachs, Benjamin P.; Epstein, Franklin H.; Sibai, Baha M.; Sukhatme, Vikas P.; Karumanchi, S. Ananth (2004). "Circulating Angiogenic Factors and the Risk of Preeclampsia". New England Journal of Medicine. 350 (7): 672–683. doi:10.1056/NEJMoa031884. ISSN 0028-4793.