Choledocholithiasis overview

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Choledocholithiasis is the presence of gallstones in the common bile duct. This condition causes jaundice and liver cell damage, and is a medical emergency, requiring the endoscopic retrograde cholangiopancreatography (ERCP) procedure or surgical treatment. A tendency for this disease can be inherited.

Historical Perspective

There is limited information about the historical perspective of choledocholithiasis

Classification

Choledocholithiasis can be classified as Primary or Secondary. Primary Choledocholithiasis is classified based on gallstones formed directly within the biliary and obstructing the common bile duct. Primary Choledocholithiasis is composed of brownstones and is less common compared to secondary choledocholithiasis. Primary choledocholithiasis often affect the biliary tree diffusely and have both intrahepatic and extrahepatic biliary stones. Intrahepatic stones may be complicated by recurrent pyogenic cholangitis.Secondary Choledocholithiasis is classified based on gallstones formed from the gallbladder and transported to block the common bile duct. This type of Choledocholithiasis is the most common type of Choledocholithiasis. The stone composition of secondary choledocholithiasis is similar to cholelithiasis with cholesterol stone as the most common type, and the cause is identical to the causes of gallstones.

Pathophysiology

It is understood that the Bile is made in the liver and stored in the gallbladder. Concentrated bile from the gallbladder can lead to the formation of gallstone. The stone passes from the gallbladder to the cystic duct, then into the common bile duct (CBD), and block the CBD. Primary Choledocholithiasis is formed from stones within the bile duct that occur due to bile stasis in the CBD, forming an intraductal stone. The cause of bile duct stasis includes bile duct dilatation with increasing age. Less commonly, bile stasis can result from complications from Mirizzi Syndrome or hepatolithiasis (gallstone in the biliary duct of the liver). The obstructed flow of the bile duct leads to obstructive jaundice and possibly hepatitis. The stagnant Bile can lead to infection and inflammation of the bile duct, causing bactibilia and ascending cholangitis. If the blockage is at the common bile duct after the pancreatic duct, join the CBD, it can become inflamed, with autoactivation of pancreatic enzymes leading to gallstone pancreatitis

References

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