Polycythemia medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
*Phlebotomy is used to decrease blood thickness. | *Phlebotomy is used to decrease blood thickness. | ||
*Medicines that may be used include: | *Medicines that may be used include:<ref name="pmid31151982">{{cite journal| author=Spivak JL| title=How I treat polycythemia vera. | journal=Blood | year= 2019 | volume= 134 | issue= 4 | pages= 341-352 | pmid=31151982 | doi=10.1182/blood.2018834044 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31151982 }} </ref> | ||
**Hydroxyurea: reduce | **Hydroxyurea: it used to reduce red blood cells counts and other blood cells if high. It also used to prevent thrombosis in patients >60 years of age with chronic PV. | ||
**Interferon: | **Interferon: reduce blood cell counts.PegIFN can be used to reduce established splenomegaly but not usually to normal size. | ||
**Anagrelide: | **Anagrelide: used to treat thrombocytosis. | ||
**Ruxolitinib ( | **Ruxolitinib (JAK1/2 inhibitor): proved to be effective in PPMF and chronic-phase PV; provided durable symptom relief, blood count control, and reduction in splenomegaly; and was superior to hydroxyurea. | ||
**Aspirin: | **Aspirin: used to prevent thrombosis. | ||
*Ultraviolet-B light therapy: reduce the itchiness. | *Ultraviolet-B light therapy: reduce the itchiness. | ||
Revision as of 19:47, 6 December 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]
Overview
- Phlebotomy is used to decrease blood thickness.
- Medicines that may be used include:[1]
- Hydroxyurea: it used to reduce red blood cells counts and other blood cells if high. It also used to prevent thrombosis in patients >60 years of age with chronic PV.
- Interferon: reduce blood cell counts.PegIFN can be used to reduce established splenomegaly but not usually to normal size.
- Anagrelide: used to treat thrombocytosis.
- Ruxolitinib (JAK1/2 inhibitor): proved to be effective in PPMF and chronic-phase PV; provided durable symptom relief, blood count control, and reduction in splenomegaly; and was superior to hydroxyurea.
- Aspirin: used to prevent thrombosis.
- Ultraviolet-B light therapy: reduce the itchiness.
Overview
- Phlebotomy is used to decrease blood thickness.
- Medicines that may be used include:[1]
- Hydroxyurea: it used to reduce red blood cells counts and other blood cells if high. It also used to prevent thrombosis in patients >60 years of age with chronic PV.
- Interferon: reduce blood cell counts.PegIFN can be used to reduce established splenomegaly but not usually to normal size.
- Anagrelide: used to treat thrombocytosis.
- Ruxolitinib (JAK1/2 inhibitor): proved to be effective in PPMF and chronic-phase PV; provided durable symptom relief, blood count control, and reduction in splenomegaly; and was superior to hydroxyurea.
- Aspirin: used to prevent thrombosis.
- Ultraviolet-B light therapy: reduce the itchiness.
References
- ↑ 1.0 1.1 Spivak JL (2019). "How I treat polycythemia vera". Blood. 134 (4): 341–352. doi:10.1182/blood.2018834044. PMID 31151982.