Polycythemia risk factors: Difference between revisions

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Revision as of 21:41, 10 December 2020

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S [2]

There are no established risk factors for Polycythemia vera except for the genetic abnormality JAK2V617F.

One of the most common and most dangerous complications of polycythemia vera is thrombus formation. The risk factors are as follows:

Women- usually younger at the time of diagnosis, have a higher risk of arterio-venous thrombosis.
Mutation- higher burden of JAK2V617F allele
Inflammatory markers- Pentraxins play an important role: increased hs-CRP and a lower PTX3 have a higher risk of thrombosis
Presence of microparticles- responsible for decreased thrombin inhibition, increased CD41, and an increased chance of splenomegaly
Neutrophil Extracellular Trap formations- NETosis and apoptosis ^[1]

@@ Line 4: / Line 4: @@
 ==Overview==
-There are no established risk factors for [disease name].
+There are no established risk factors for Polycythemia vera except for the genetic abnormality JAK2V617F.
-OR
-The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].
-OR
-Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
-OR
-Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.
 ==Risk Factors==