Polycythemia risk factors: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Polycythemia}} | {{Polycythemia}} | ||
{{CMG}}{{AE}}{{Debduti}} | {{CMG}} ; {{AE}} {{Debduti}} | ||
==Overview== | ==Overview== | ||
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==Risk Factors== | ==Risk Factors== | ||
*One of the most common and most dangerous complications of polycythemia vera is thrombus formation. The risk factors are as follows: | *One of the most common and most dangerous complications of polycythemia vera is thrombus formation. The risk factors are as follows: | ||
*Women- usually younger at the time of diagnosis, have a higher risk of arterio-venous thrombosis. | *Women- usually younger at the time of diagnosis, have a higher risk of arterio-venous thrombosis. | ||
*Mutation- higher burden of JAK2V617F allele | *Mutation- the higher burden of JAK2V617F allele | ||
*Inflammatory markers- Pentraxins play an important role: increased hs-CRP and a lower PTX3 have a higher risk of thrombosis | *Inflammatory markers- Pentraxins play an important role: increased hs-CRP and a lower PTX3 have a higher risk of thrombosis | ||
*Presence of microparticles- responsible for decreased thrombin inhibition, increased CD41, and an increased chance of splenomegaly | *Presence of microparticles- responsible for decreased thrombin inhibition, increased CD41, and an increased chance of splenomegaly | ||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Emergency medicine]] | [[Category:Emergency medicine]] | ||
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[[Category:Blood disorders]] | [[Category:Blood disorders]] | ||
[[Category:Up-To-Date]] | [[Category:Up-To-Date]] | ||
Revision as of 16:49, 2 March 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]
Overview
There are no established risk factors for developing polycythemia vera except for the genetic abnormality JAK2V617F.
Risk Factors
- One of the most common and most dangerous complications of polycythemia vera is thrombus formation. The risk factors are as follows:
- Women- usually younger at the time of diagnosis, have a higher risk of arterio-venous thrombosis.
- Mutation- the higher burden of JAK2V617F allele
- Inflammatory markers- Pentraxins play an important role: increased hs-CRP and a lower PTX3 have a higher risk of thrombosis
- Presence of microparticles- responsible for decreased thrombin inhibition, increased CD41, and an increased chance of splenomegaly
- Neutrophil Extracellular Trap formations- NETosis and apoptosis [1]