Polycythemia laboratory findings: Difference between revisions
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==Laboratory Findings== | ==Laboratory Findings== | ||
World Health Organization diagnostic criteria for Polycythemia Vera: | World Health Organization diagnostic criteria for Polycythemia Vera:<ref name="pmid16879013">{{cite journal| author=Cao M, Olsen RJ, Zu Y| title=Polycythemia vera: new clinicopathologic perspectives. | journal=Arch Pathol Lab Med | year= 2006 | volume= 130 | issue= 8 | pages= 1126-32 | pmid=16879013 | doi=10.1043/1543-2165(2006)130[1126:PV]2.0.CO;2 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16879013 }} </ref> | ||
*A1 Elevated RBC mass >25% above mean normal predicted value, or Hb>18.5g/dl in men, 16.5g/dl in women | *A1 Elevated RBC mass >25% above mean normal predicted value, or Hb>18.5g/dl in men, 16.5g/dl in women | ||
*A2 No cause of secondary Erythrocytosis include absence of familial Erythrocytosis; no elevation of erythropoietin due to hypoxia (arterial PO2</= 92%), high oxygen affinity hemoglobin, truncated erythropoietin receptors, inappropriate erythropoietin production by tumor | *A2 No cause of secondary Erythrocytosis include absence of familial Erythrocytosis; no elevation of erythropoietin due to hypoxia (arterial PO2</= 92%), high oxygen affinity hemoglobin, truncated erythropoietin receptors, inappropriate erythropoietin production by tumor |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]
Laboratory Findings
World Health Organization diagnostic criteria for Polycythemia Vera:[1]
- A1 Elevated RBC mass >25% above mean normal predicted value, or Hb>18.5g/dl in men, 16.5g/dl in women
- A2 No cause of secondary Erythrocytosis include absence of familial Erythrocytosis; no elevation of erythropoietin due to hypoxia (arterial PO2</= 92%), high oxygen affinity hemoglobin, truncated erythropoietin receptors, inappropriate erythropoietin production by tumor
- A3 Splenomegaly
- A4 Clonal genetic abnormality other than Ph chromosome or BCR/ABL fusion gene in marrow cells
- A5 Endogenous erythroid colony formation in vitro
- B1 Thrombocytosis >400x10ª/L
- B2 WBC >12x10ª/L
- B3 Bone marrow biopsy showing panmyelosiswith prominent erythroid and megakaryocytic proliferation
- B4 Low serum EPO levels
Laboratory Findings
Laboratory findings consistent with the diagnosis of polycythemia include:
- [Complete blood count CBC]
- [Blood smear]
- [Erythropoietin test]
References
- ↑ Cao M, Olsen RJ, Zu Y (2006). "Polycythemia vera: new clinicopathologic perspectives". Arch Pathol Lab Med. 130 (8): 1126–32. doi:10.1043/1543-2165(2006)130[1126:PV]2.0.CO;2. PMID 16879013.