Polycythemia laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]

Laboratory Findings

World Health Organization diagnostic criteria for Polycythemia Vera:

• A1 Elevated RBC mass >25% above mean normal predicted value, or Hb>18.5g/dl in men, 16.5g/dl in women
• A2 No cause of secondary Erythrocytosis include absence of familial Erythrocytosis; no elevation of erythropoietin due to hypoxia (arterial PO2</= 92%), high oxygen affinity hemoglobin, truncated erythropoietin receptors, inappropriate erythropoietin production by tumor
• A3 Splenomegaly
• A4 Clonal genetic abnormality other than Ph chromosome or BCR/ABL fusion gene in marrow cells
• A5 Endogenous erythroid colony formation in vitro
• B1 Thrombocytosis >400x10ª/L
• B2 WBC >12x10ª/L
• B3 Bone marrow biopsy showing panmyelosiswith prominent erythroid and megakaryocytic proliferation
• B4 Low serum EPO levels

-Polycythemia diagnosed when A1 + A2 any other A or A1 + A2 + any other 2B. RBC indicated red blood cell; Hb, hemoglobin; Ph, Philadelphia; WBC, white blood cell; and EPO, erythropoietin.