Chronic obstructive pulmonary disease study of choice: Difference between revisions
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{{Chronic obstructive pulmonary disease}} | {{Chronic obstructive pulmonary disease}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} | ||
== Overview == | ==Overview== | ||
== Diagnostic Study of Choice == | ==Diagnostic Study of Choice== | ||
=== Study of choice === | ===Study of choice=== | ||
===Pulmonary Function Test / Spirometry=== | |||
*COPD is particularly characterized if a ratio of forced expiratory volume over 1 second ([https://www.wikidoc.org/index.php/FEV1 FEV<sub>1</sub>]) to [https://www.wikidoc.org/index.php/Forced_vital_capacity forced vital capacity] (FVC) being < 0.7 and the [https://www.wikidoc.org/index.php/FEV1 FEV<sub>1</sub>] < 70% of the predicted value when compared with a matched control. <ref>[http://www.patient.co.uk/showdoc/40002357/ PatientPlus - Spirometry]</ref>, <ref name="pmid22319804">{{cite journal |author= |title= |journal=[[]] |volume= |issue= |pages= |year= |pmid=22319804 |doi= |url= |accessdate=2012-03-05}}</ref> (see [https://www.wikidoc.org/index.php/Spirometry Spirometry]). | |||
*Normally, at least 70% of the FVC comes out in the first second (i.e. the [https://www.wikidoc.org/index.php/FEV1/FVC FEV<sub>1</sub>/FVC ratio] is >70%). A ratio less than normal defines the patient as having COPD. | |||
*More specifically, the diagnosis of COPD is made when the FEV<sub>1</sub>/FVC ratio is <70%. | |||
*The GOLD criteria also require that values are after [https://www.wikidoc.org/index.php/Bronchodilator bronchodilator] medication has been given to make the diagnosis, | |||
*The NICE criteria also require FEV1%. | |||
*According to the ERS criteria, it is [https://www.wikidoc.org/index.php/FEV1%25_predicted FEV1% predicted] that defines when a patient has COPD, that is, when FEV1% predicted is < 88% for men, or < 89% for women. | |||
*Spirometry can help to determine the severity of COPD.<ref name="pmid17507545">{{cite journal |author=Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, Zielinski J |title=Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary |journal=[[American Journal of Respiratory and Critical Care Medicine]] |volume=176 |issue=6 |pages=532–55 |year=2007 |month=September |pmid=17507545 |doi=10.1164/rccm.200703-456SO |url=http://ajrccm.atsjournals.org/cgi/pmidlookup?view=long&pmid=17507545 |accessdate=2012-03-02}}</ref> | |||
*The FEV<sub>1</sub> (measured after bronchodilator medication) is expressed as a percentage of a predicted "normal" value based on a person's age, gender, height and weight: | |||
*The severity of COPD also depends on the severity of dyspnea and exercise limitation. These and other factors can be combined with spirometry results to obtain a COPD severity score that takes multiple dimensions of the disease into account.<ref name="Celli04">{{cite journal |author=Celli BR, Cote CG, Marin JM, ''et al.'' |title=The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease |journal=N. Engl. J. Med. |volume=350 |issue=10 |pages=1005–12 |year=2004 |month=March |pmid=14999112 |doi=10.1056/NEJMoa021322 }}</ref> | |||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
Diagnostic Study of Choice
Study of choice
Pulmonary Function Test / Spirometry
- COPD is particularly characterized if a ratio of forced expiratory volume over 1 second (FEV1) to forced vital capacity (FVC) being < 0.7 and the FEV1 < 70% of the predicted value when compared with a matched control. [1], [2] (see Spirometry).
- Normally, at least 70% of the FVC comes out in the first second (i.e. the FEV1/FVC ratio is >70%). A ratio less than normal defines the patient as having COPD.
- More specifically, the diagnosis of COPD is made when the FEV1/FVC ratio is <70%.
- The GOLD criteria also require that values are after bronchodilator medication has been given to make the diagnosis,
- The NICE criteria also require FEV1%.
- According to the ERS criteria, it is FEV1% predicted that defines when a patient has COPD, that is, when FEV1% predicted is < 88% for men, or < 89% for women.
- Spirometry can help to determine the severity of COPD.[3]
- The FEV1 (measured after bronchodilator medication) is expressed as a percentage of a predicted "normal" value based on a person's age, gender, height and weight:
- The severity of COPD also depends on the severity of dyspnea and exercise limitation. These and other factors can be combined with spirometry results to obtain a COPD severity score that takes multiple dimensions of the disease into account.[4]
References
- ↑ PatientPlus - Spirometry
- ↑ [[]]. PMID 22319804. Missing or empty
|title=
(help);|access-date=
requires|url=
(help) - ↑ Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, Zielinski J (2007). "Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary". American Journal of Respiratory and Critical Care Medicine. 176 (6): 532–55. doi:10.1164/rccm.200703-456SO. PMID 17507545. Retrieved 2012-03-02. Unknown parameter
|month=
ignored (help) - ↑ Celli BR, Cote CG, Marin JM; et al. (2004). "The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease". N. Engl. J. Med. 350 (10): 1005–12. doi:10.1056/NEJMoa021322. PMID 14999112. Unknown parameter
|month=
ignored (help)