Headaches in children pathophysiology: Difference between revisions

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VisualWikitext

Latest revision as of 16:45, 3 March 2021

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

It is thought that [disease name] is the result of / is mediated by / is produced by / is caused by either [hypothesis 1], [hypothesis 2], or [hypothesis 3].

[Pathogen name] is usually transmitted via the [transmission route] route to the human host.

Following transmission/ingestion, the [pathogen] uses the [entry site] to invade the [cell name] cell.

Pathophysiology

Physiology

The normal physiology of [name of process] can be understood as follows:

Pathogenesis

It is understood that primary headache disorder is not due to an underlying disorder and secondary headache disorder is caused by either trauma^[1], vascular^[1], infections^[2], inflammatory^[3], structural^[3], tumors^[2], metabolic^[1], epilepsy^[3], or hypoxia^[1].

Genetics

[Disease name] is transmitted in [mode of genetic transmission] pattern.

OR

Genes involved in the pathogenesis of [disease name] include:

[Gene1]
[Gene2]
[Gene3]

OR

The development of [disease name] is the result of multiple genetic mutations such as:

[Mutation 1]
[Mutation 2]
[Mutation 3]

Associated Conditions

Conditions associated with [disease name] include:

[Condition 1]
[Condition 2]
[Condition 3]

Gross Pathology

On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].

Microscopic Pathology

On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 Kelly M, Strelzik J, Langdon R, DiSabella M (2018). "Pediatric headache: overview". Curr Opin Pediatr. 30 (6): 748–754. doi:10.1097/MOP.0000000000000688. PMID 30157045.
↑ ^2.0 ^2.1 Ozge A, Termine C, Antonaci F, Natriashvili S, Guidetti V, Wöber-Bingöl C (2011). "Overview of diagnosis and management of paediatric headache. Part I: diagnosis". J Headache Pain. 12 (1): 13–23. doi:10.1007/s10194-011-0297-5. PMC 3056001. PMID 21359874.
↑ ^3.0 ^3.1 ^3.2 Ahad R, Kossoff EH (2008). "Secondary intracranial causes for headaches in children". Curr Pain Headache Rep. 12 (5): 373–8. doi:10.1007/s11916-008-0063-9. PMID 18765144.

Template:WH Template:WS

[pmid30157045-1] 1.0 ^1.1 ^1.2 ^1.3 Kelly M, Strelzik J, Langdon R, DiSabella M (2018). "Pediatric headache: overview". Curr Opin Pediatr. 30 (6): 748–754. doi:10.1097/MOP.0000000000000688. PMID 30157045.

[pmid21359874-2] 2.0 ^2.1 Ozge A, Termine C, Antonaci F, Natriashvili S, Guidetti V, Wöber-Bingöl C (2011). "Overview of diagnosis and management of paediatric headache. Part I: diagnosis". J Headache Pain. 12 (1): 13–23. doi:10.1007/s10194-011-0297-5. PMC 3056001. PMID 21359874.

[pmid18765144-3] 3.0 ^3.1 ^3.2 Ahad R, Kossoff EH (2008). "Secondary intracranial causes for headaches in children". Curr Pain Headache Rep. 12 (5): 373–8. doi:10.1007/s11916-008-0063-9. PMID 18765144.

[1]

[2]

[3]

@@ Line 17: / Line 17: @@
 ===Pathogenesis===
-*It is understood that [[primary headache disorder]] is not due to an underlying disorder and [[secondary headache disorder]] is caused by either [[trauma]]<ref name="pmid30157045">{{cite journal| author=Kelly M, Strelzik J, Langdon R, DiSabella M| title=Pediatric headache: overview. | journal=Curr Opin Pediatr | year= 2018 | volume= 30 | issue= 6 | pages= 748-754 | pmid=30157045 | doi=10.1097/MOP.0000000000000688 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30157045  }} </ref>, [[vascular]]<ref name="pmid30157045">{{cite journal| author=Kelly M, Strelzik J, Langdon R, DiSabella M| title=Pediatric headache: overview. | journal=Curr Opin Pediatr | year= 2018 | volume= 30 | issue= 6 | pages= 748-754 | pmid=30157045 | doi=10.1097/MOP.0000000000000688 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30157045  }} </ref>, [[infections]]<ref name="pmid21359874">{{cite journal| author=Ozge A, Termine C, Antonaci F, Natriashvili S, Guidetti V, Wöber-Bingöl C| title=Overview of diagnosis and management of paediatric headache. Part I: diagnosis. | journal=J Headache Pain | year= 2011 | volume= 12 | issue= 1 | pages= 13-23 | pmid=21359874 | doi=10.1007/s10194-011-0297-5 | pmc=3056001 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21359874  }} </ref>, [[inflammatory]]<ref name="pmid18765144">{{cite journal| author=Ahad R, Kossoff EH| title=Secondary intracranial causes for headaches in children. | journal=Curr Pain Headache Rep | year= 2008 | volume= 12 | issue= 5 | pages= 373-8 | pmid=18765144 | doi=10.1007/s11916-008-0063-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18765144  }} </ref>, [[structural]]<ref name="pmid18765144">{{cite journal| author=Ahad R, Kossoff EH| title=Secondary intracranial causes for headaches in children. | journal=Curr Pain Headache Rep | year= 2008 | volume= 12 | issue= 5 | pages= 373-8 | pmid=18765144 | doi=10.1007/s11916-008-0063-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18765144  }} </ref>, [[tumors]]<ref name="pmid21359874">{{cite journal| author=Ozge A, Termine C, Antonaci F, Natriashvili S, Guidetti V, Wöber-Bingöl C| title=Overview of diagnosis and management of paediatric headache. Part I: diagnosis. | journal=J Headache Pain | year= 2011 | volume= 12 | issue= 1 | pages= 13-23 | pmid=21359874 | doi=10.1007/s10194-011-0297-5 | pmc=3056001 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21359874  }} </ref>, [[metabolic]]<ref name="pmid30157045">{{cite journal| author=Kelly M, Strelzik J, Langdon R, DiSabella M| title=Pediatric headache: overview. | journal=Curr Opin Pediatr | year= 2018 | volume= 30 | issue= 6 | pages= 748-754 | pmid=30157045 | doi=10.1097/MOP.0000000000000688 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30157045  }} </ref>, or [[hypoxia]]<ref name="pmid30157045">{{cite journal| author=Kelly M, Strelzik J, Langdon R, DiSabella M| title=Pediatric headache: overview. | journal=Curr Opin Pediatr | year= 2018 | volume= 30 | issue= 6 | pages= 748-754 | pmid=30157045 | doi=10.1097/MOP.0000000000000688 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30157045  }} </ref>.
+*It is understood that [[primary headache disorder]] is not due to an underlying disorder and [[secondary headache disorder]] is caused by either [[trauma]]<ref name="pmid30157045">{{cite journal| author=Kelly M, Strelzik J, Langdon R, DiSabella M| title=Pediatric headache: overview. | journal=Curr Opin Pediatr | year= 2018 | volume= 30 | issue= 6 | pages= 748-754 | pmid=30157045 | doi=10.1097/MOP.0000000000000688 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30157045  }} </ref>, [[vascular]]<ref name="pmid30157045">{{cite journal| author=Kelly M, Strelzik J, Langdon R, DiSabella M| title=Pediatric headache: overview. | journal=Curr Opin Pediatr | year= 2018 | volume= 30 | issue= 6 | pages= 748-754 | pmid=30157045 | doi=10.1097/MOP.0000000000000688 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30157045  }} </ref>, [[infections]]<ref name="pmid21359874">{{cite journal| author=Ozge A, Termine C, Antonaci F, Natriashvili S, Guidetti V, Wöber-Bingöl C| title=Overview of diagnosis and management of paediatric headache. Part I: diagnosis. | journal=J Headache Pain | year= 2011 | volume= 12 | issue= 1 | pages= 13-23 | pmid=21359874 | doi=10.1007/s10194-011-0297-5 | pmc=3056001 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21359874  }} </ref>, [[inflammatory]]<ref name="pmid18765144">{{cite journal| author=Ahad R, Kossoff EH| title=Secondary intracranial causes for headaches in children. | journal=Curr Pain Headache Rep | year= 2008 | volume= 12 | issue= 5 | pages= 373-8 | pmid=18765144 | doi=10.1007/s11916-008-0063-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18765144  }} </ref>, [[structural]]<ref name="pmid18765144">{{cite journal| author=Ahad R, Kossoff EH| title=Secondary intracranial causes for headaches in children. | journal=Curr Pain Headache Rep | year= 2008 | volume= 12 | issue= 5 | pages= 373-8 | pmid=18765144 | doi=10.1007/s11916-008-0063-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18765144  }} </ref>, [[tumors]]<ref name="pmid21359874">{{cite journal| author=Ozge A, Termine C, Antonaci F, Natriashvili S, Guidetti V, Wöber-Bingöl C| title=Overview of diagnosis and management of paediatric headache. Part I: diagnosis. | journal=J Headache Pain | year= 2011 | volume= 12 | issue= 1 | pages= 13-23 | pmid=21359874 | doi=10.1007/s10194-011-0297-5 | pmc=3056001 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21359874  }} </ref>, [[metabolic]]<ref name="pmid30157045">{{cite journal| author=Kelly M, Strelzik J, Langdon R, DiSabella M| title=Pediatric headache: overview. | journal=Curr Opin Pediatr | year= 2018 | volume= 30 | issue= 6 | pages= 748-754 | pmid=30157045 | doi=10.1097/MOP.0000000000000688 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30157045  }} </ref>, [[epilepsy]]<ref name="pmid18765144">{{cite journal| author=Ahad R, Kossoff EH| title=Secondary intracranial causes for headaches in children. | journal=Curr Pain Headache Rep | year= 2008 | volume= 12 | issue= 5 | pages= 373-8 | pmid=18765144 | doi=10.1007/s11916-008-0063-9 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18765144  }} </ref>, or [[hypoxia]]<ref name="pmid30157045">{{cite journal| author=Kelly M, Strelzik J, Langdon R, DiSabella M| title=Pediatric headache: overview. | journal=Curr Opin Pediatr | year= 2018 | volume= 30 | issue= 6 | pages= 748-754 | pmid=30157045 | doi=10.1097/MOP.0000000000000688 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=30157045  }} </ref>.
 ==Genetics==