Acrodermatitis chronica atrophicans history and symptoms: Difference between revisions
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*[[Sclerosis|Sclerotic]] [[skin]] plaques may also develop. | *[[Sclerosis|Sclerotic]] [[skin]] plaques may also develop. | ||
*[[Acrodermatitis chronica atrophicans]] can progress and cause [[wrinkle]]. | *[[Acrodermatitis chronica atrophicans]] can progress and cause [[wrinkle]]. | ||
*The following are [[symptoms]] have been observed in [[acrodermatitis chronica atrophicans]]:<ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref><ref name="pmid33550695">{{cite journal| author=Ogrinc K, Maraspin V, Lusa L, Cerar Kišek T, Ružić-Sabljić E, Strle F| title=Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients. | journal=J Intern Med | year= 2021 | volume= | issue= | pages= | pmid=33550695 | doi=10.1111/joim.13266 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33550695 }} </ref><ref name="KaminskyMaisonobe2020">{{cite journal|last1=Kaminsky|first1=Anne-Laure|last2=Maisonobe|first2=Thierry|last3=Lenglet|first3=Timothée|last4=Psimaras|first4=Dimitri|last5=Debs|first5=Rabab|last6=Viala|first6=Karine|title=Confirmed cases of Neuroborreliosis with involvement of peripheral nervous system|journal=Medicine|volume=99|issue=40|year=2020|pages=e21986|issn=0025-7974|doi=10.1097/MD.0000000000021986}}</ref> | *The following are [[symptoms]] have been observed in [[acrodermatitis chronica atrophicans]]:<ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref><ref name="pmid33550695">{{cite journal| author=Ogrinc K, Maraspin V, Lusa L, Cerar Kišek T, Ružić-Sabljić E, Strle F| title=Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients. | journal=J Intern Med | year= 2021 | volume= | issue= | pages= | pmid=33550695 | doi=10.1111/joim.13266 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33550695 }} </ref><ref name="KaminskyMaisonobe2020">{{cite journal|last1=Kaminsky|first1=Anne-Laure|last2=Maisonobe|first2=Thierry|last3=Lenglet|first3=Timothée|last4=Psimaras|first4=Dimitri|last5=Debs|first5=Rabab|last6=Viala|first6=Karine|title=Confirmed cases of Neuroborreliosis with involvement of peripheral nervous system|journal=Medicine|volume=99|issue=40|year=2020|pages=e21986|issn=0025-7974|doi=10.1097/MD.0000000000021986}}</ref><ref name="Muller2012">{{cite journal|last1=Muller|first1=Kurt E.|title=Damage of Collagen and Elastic Fibres by Borrelia Burgdorferi – Known and New Clinical and Histopathological Aspects|journal=The Open Neurology Journal|volume=6|issue=1|year=2012|pages=179–186|issn=1874205X|doi=10.2174/1874205X01206010179}}</ref> | ||
**Sclerotic [[skin]] lesions | **Sclerotic [[skin]] lesions | ||
**[[Pain]] and burning | **[[Pain]] and burning | ||
**[[Edema]] | **[[Edema]] | ||
**[[Wrinkles]] | **[[Wrinkles]] | ||
**[[Peripheral neuropathy]] | **[[Peripheral neuropathy]] (develop in half of [[patients]]) | ||
***Such as [[paresthesia]] and [[hypesthesia]] | ***Such as [[paresthesia]] and [[hypesthesia]] | ||
***Some [[patients]] develop [[symptoms]] related to [[peripheral neuropathy]] at the exact site of [[acrodermatitis chronica atrophicans]]'s lesion, nevertheless there are other [[patients]] that experienced these [[symptoms]] at other sites. | ***Some [[patients]] develop [[symptoms]] related to [[peripheral neuropathy]] at the exact site of [[acrodermatitis chronica atrophicans]]'s lesion, nevertheless there are other [[patients]] that experienced these [[symptoms]] at other sites. | ||
| Line 34: | Line 34: | ||
**[[B symptoms|Constitutional symptoms]] | **[[B symptoms|Constitutional symptoms]] | ||
**[[Joint]] deformities | **[[Joint]] deformities | ||
**Band-like [[induration]] on [[Limb (anatomy)|extremities]] | |||
*Based on a study done on 693 [[patients]] suffering from [[acrodermatitis chronica atrophicans]]:<ref name="pmid33550695">{{cite journal| author=Ogrinc K, Maraspin V, Lusa L, Cerar Kišek T, Ružić-Sabljić E, Strle F| title=Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients. | journal=J Intern Med | year= 2021 | volume= | issue= | pages= | pmid=33550695 | doi=10.1111/joim.13266 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33550695 }} </ref> | *Based on a study done on 693 [[patients]] suffering from [[acrodermatitis chronica atrophicans]]:<ref name="pmid33550695">{{cite journal| author=Ogrinc K, Maraspin V, Lusa L, Cerar Kišek T, Ružić-Sabljić E, Strle F| title=Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients. | journal=J Intern Med | year= 2021 | volume= | issue= | pages= | pmid=33550695 | doi=10.1111/joim.13266 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33550695 }} </ref> | ||
**Involvement of [[leg|lower limb]] (70%) has been more common compared to [[upper limb]] (45.2%). | **Involvement of [[leg|lower limb]] (70%) has been more common compared to [[upper limb]] (45.2%). | ||
Revision as of 01:54, 11 June 2021
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anahita Deylamsalehi, M.D.[2] Raviteja Guddeti, M.B.B.S. [3]
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Overview
History and Symptoms
History
The following are some of the common findings in patients' history:[1][2][3][4]
- Tick bite
- Erythema migrans
- Some of the patients in a study experienced erythema migrans 6 months to 8 years before acrodermatitis chronica atrophicansis development.
- Neurological symptoms
- Rheumatological symptoms
Symptoms
- Symptoms and different forms of skin involvement in acrodermatitis chronica atrophicans are dependent to duration of the disease.[3]
- It usually involves extensor surfaces of the acral regions of limbs beginning with an inflammatory stage (bluish red discoloration and edema followed by an atrophic phase).
- Sclerotic skin plaques may also develop.
- Acrodermatitis chronica atrophicans can progress and cause wrinkle.
- The following are symptoms have been observed in acrodermatitis chronica atrophicans:[1][3][5][6]
- Sclerotic skin lesions
- Pain and burning
- Edema
- Wrinkles
- Peripheral neuropathy (develop in half of patients)
- Such as paresthesia and hypesthesia
- Some patients develop symptoms related to peripheral neuropathy at the exact site of acrodermatitis chronica atrophicans's lesion, nevertheless there are other patients that experienced these symptoms at other sites.
- Most of the times it presents as asymmetric distal sensory disturbance, which could be painful or painless.
- Arthropathy
- Constitutional symptoms
- Joint deformities
- Band-like induration on extremities
- Based on a study done on 693 patients suffering from acrodermatitis chronica atrophicans:[3]
- Involvement of lower limb (70%) has been more common compared to upper limb (45.2%).
- In 42.4% of cases acral involvement occurred bilaterally.
- Only 2 among 693 patients had skin involvement on areas other than extremities.
- Less than 3% of studied patients had symptoms such as nodule, arthritis, itching, muscle atrophy, joint deformities and paresis.
- Small fraction of patients didn't experience any skin discoloration and their main presentations were edema and atrophic changes.
References
- ↑ 1.0 1.1 Asbrink E, Hovmark A, Olsson I (1986). "Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients". Zentralbl Bakteriol Mikrobiol Hyg A. 263 (1–2): 253–61. doi:10.1016/s0176-6724(86)80128-6. PMID 3577484.
- ↑ Asbrink E, Hovmark A, Hederstedt B (1984). "The spirochetal etiology of acrodermatitis chronica atrophicans Herxheimer". Acta Derm Venereol. 64 (6): 506–12. PMID 6084922.
- ↑ 3.0 3.1 3.2 3.3 Ogrinc K, Maraspin V, Lusa L, Cerar Kišek T, Ružić-Sabljić E, Strle F (2021). "Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients". J Intern Med. doi:10.1111/joim.13266. PMID 33550695 Check
|pmid=value (help). - ↑ "StatPearls". 2021. PMID 33085436 Check
|pmid=value (help). - ↑ Kaminsky, Anne-Laure; Maisonobe, Thierry; Lenglet, Timothée; Psimaras, Dimitri; Debs, Rabab; Viala, Karine (2020). "Confirmed cases of Neuroborreliosis with involvement of peripheral nervous system". Medicine. 99 (40): e21986. doi:10.1097/MD.0000000000021986. ISSN 0025-7974.
- ↑ Muller, Kurt E. (2012). "Damage of Collagen and Elastic Fibres by Borrelia Burgdorferi – Known and New Clinical and Histopathological Aspects". The Open Neurology Journal. 6 (1): 179–186. doi:10.2174/1874205X01206010179. ISSN 1874-205X.