Eczema causes: Difference between revisions
Jump to navigation
Jump to search
Tag: Undo |
No edit summary |
||
| Line 3: | Line 3: | ||
==Overview== | ==Overview== | ||
There are several possible causes of [[eczema]], majority of which are [[genetic]] in origin. [[Adverse drug effects]] also manifest as [[eczema]]. | |||
==Causes== | ==Causes== | ||
Damage from the [[Enzyme|enzymatic]] activity of allergens is usually prevented by the body's own [[protease inhibitor]]s, such as, LEKTI, produced from the gene [[SPINK5]]. | *Damage from the [[Enzyme|enzymatic]] activity of [[allergens]] is usually prevented by the body's own [[protease inhibitor]]s, such as, ''[[LEKTI]]'', produced from the gene ''[[SPINK5]]''. | ||
**[[Netherton’s syndrome]], a [[congenital]] condition presenting with [[erythroderma]], [[food allergy]], [[hay fever]], [[asthma]], and [[urticaria]], results from the [[mutation]] of this [[gene]]. <ref name="pmid11544479">{{cite journal |author=Walley AJ, Chavanas S, Moffatt MF, ''et al'' |title=Gene polymorphism in Netherton and common atopic disease |journal=Nat. Genet. |volume=29 |issue=2 |pages=175–8 |year=2001[[Mutations]] in this gene are known to cause |pmid=11544479 |doi=10.1038/ng728}}</ref> | |||
*Lack of [[filaggrin]] [[gene]] causes [[dry skin]] and impaired [[skin]] [[barrier]] [[function]]. <ref name=filaggrin>Palmer, C.N. ''et al.'' (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. ''Nature Genetics'' '''38'''(4), 441-6. PMID 16550169</ref> | |||
*[[Brain-derived neurotrophic factor]] (BDNF) and [[Substance P]], are responsible for the [[pruritic]] sensation in [[eczema]]. <ref name="BBC-blood chemicals">{{cite news |author= |title= 'Blood chemicals link' to eczema -- Scientists have identified two blood chemicals linked to itchy eczema, offering new treatment possibilities. |url= http://news.bbc.co.uk/2/hi/health/6962450.stm |date= 26 August 2007 |publisher=BBC News |accessdate=2007-10-16}}</ref> | |||
===Common Causes=== | ===Common Causes=== | ||
Revision as of 01:48, 18 May 2022
|
Eczema Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Eczema On the Web |
|
American Roentgen Ray Society Images of Eczema |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.
Overview
There are several possible causes of eczema, majority of which are genetic in origin. Adverse drug effects also manifest as eczema.
Causes
- Damage from the enzymatic activity of allergens is usually prevented by the body's own protease inhibitors, such as, LEKTI, produced from the gene SPINK5.
- Netherton’s syndrome, a congenital condition presenting with erythroderma, food allergy, hay fever, asthma, and urticaria, results from the mutation of this gene. [1]
- Brain-derived neurotrophic factor (BDNF) and Substance P, are responsible for the pruritic sensation in eczema. [3]
Common Causes
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Cidofovir, Flurbiprofen, Olaparib, Siltuximab, Sorafenib, Tiagabine |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
Causes in Alphabetical Order
- List the causes of the disease in alphabetical order. You may need to list across the page, as seen here
References
- ↑ Walley AJ, Chavanas S, Moffatt MF; et al. (2001Mutations in this gene are known to cause). "Gene polymorphism in Netherton and common atopic disease". Nat. Genet. 29 (2): 175–8. doi:10.1038/ng728. PMID 11544479. Check date values in:
|year=(help) - ↑ Palmer, C.N. et al. (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nature Genetics 38(4), 441-6. PMID 16550169
- ↑ "'Blood chemicals link' to eczema -- Scientists have identified two blood chemicals linked to itchy eczema, offering new treatment possibilities". BBC News. 26 August 2007. Retrieved 2007-10-16.