Eczema differential diagnosis: Difference between revisions

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Revision as of 21:05, 25 May 2022

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.

Several medical conditions can mimic eczema, with overlapping features. These conditions could be due to an inflammation, neoplasm, immunodeficiency, or a nutritional deficiency problem.
Table 1 summarizes these medical conditions, with their corresponding expected time of presentations.

**Table 1. Differential Diagnosis of Eczema.**^[1]
Type	Medical Condition	Manifestations	Expected Time of Presentation

Inflammatory	Psoriasis	Plaque with silvery scales.	Adolescence to adulthood.
	Viral Exanthem	Morbiliform rash	Infancy.
	Contact Dermatitis	Vesicular and pruritic.	Infancy.
Neoplastic	Cutaneous T-cell Lymphoma	Eczematous patch. Resistant to topical steroids.	Adulthood.
Immunodeficiency	Wiskott-Aldrich Syndrome	Recurrent infections, failure to thrive, and resistant to topical steroids.	Infancy.
	Netherton syndrome	Recurrent infections, failure to thrive, and resistant to topical steroids.	Infancy.
	Hyper IgE syndrome	Recurrent infections, failure to thrive, and resistant to topical steroids.	Infancy.
	DOCK8	Recurrent infections, failure to thrive, and resistant to topical steroids.	Infancy.
Nutritional Deficiency	Zinc	Weight loss.	Infancy to early childhood.
Nutritional Deficiency	Biotin	Failure to thrive.	Infancy to early childhood.

↑ ^1.0 ^1.1 Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID https://doi.org/10.3390/jcm4050884 Check |pmid= value (help).

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 ==Overview==
-Several [[medical conditions]] can mimic [[eczema]], with overlapping features. These conditions could be due to an [[inflammatory]], [[infectious]], [[immunodeficiency]], or a [[nutritional deficiency]] problem. It is important to differentiate one from another to render proper [[medical treatment]].<ref name="pmidhttps://doi.org/10.3390/jcm4050884">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=https://doi.org/10.3390/jcm4050884 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10  }} </ref>
+[[Differential diagnoses]] of [[eczema]] include [[infectious disease]], [[inflammatory disease]], [[immunodeficiency problem]], or a [[nutritional deficiency]].<ref name="pmidhttps://doi.org/10.3390/jcm4050884">{{cite journal| author=Schmoldt A, Benthe HF, Haberland G| title=Digitoxin metabolism by rat liver microsomes. | journal=Biochem Pharmacol | year= 1975 | volume= 24 | issue= 17 | pages= 1639-41 | pmid=https://doi.org/10.3390/jcm4050884 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10  }} </ref>
 ==Differential Diagnosis==