Eczema causes: Difference between revisions

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Revision as of 01:44, 26 May 2022

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.

Eczema could be due to a genetic problem, or a result of the adverse effect of certain medication.

Damage from the enzymatic activity of allergens is usually prevented by the body's own protease inhibitors, such as, LEKTI, produced from the gene SPINK5.
Lack of filaggrin gene causes dry skin and impaired skin barrier function. ^[1]

Below is a list of commonly prescribed medications with eczema as the common adverse drug effect (Table 1).

↑ Palmer, C.N. et al. (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nature Genetics 38(4), 441-6. PMID 16550169

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 ==Causes==
 *Damage from the [[Enzyme|enzymatic]] activity of [[allergens]] is usually prevented by the body's own [[protease inhibitor]]s, such as, ''[[LEKTI]]'',  produced from the gene ''[[SPINK5]]''.
-**[[Netherton’s syndrome]], a [[congenital]] condition presenting with [[erythroderma]], [[food allergy]], [[hay fever]], [[asthma]], and [[urticaria]], results from the [[mutation]] of this [[gene]]. <ref name="pmid11544479">{{cite journal |author=Walley AJ, Chavanas S, Moffatt MF, ''et al'' |title=Gene polymorphism in Netherton and common atopic disease |journal=Nat. Genet. |volume=29 |issue=2 |pages=175–8 |year=2001[[Mutations]] in this gene are known to cause  |pmid=11544479 |doi=10.1038/ng728}}</ref>
 *Lack of [[filaggrin]] [[gene]] causes [[dry skin]] and impaired [[skin]] [[barrier]] [[function]]. <ref name=filaggrin>Palmer, C.N. ''et al.'' (2006) Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. ''Nature Genetics''  '''38'''(4), 441-6. PMID 16550169</ref>