Eczema causes: Difference between revisions
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The [[etiology]] of [[eczema]] is multifactorial and complex. This involves aberrations in [[genetic]] component, [[adverse effect]] of certain [[medication]] and some environmental factors. | The [[etiology]] of [[eczema]] is multifactorial and complex. This involves aberrations in [[genetic]] component, [[adverse effect]] of certain [[medication]] and some environmental factors. | ||
== | ==Etiology of Eczema== | ||
===Genetic problem=== | |||
*Damage from the [[Enzyme|enzymatic]] activity of [[allergens]] is usually prevented by the body's own [[protease inhibitor]]s, such as, ''[[LEKTI]]'', produced from the gene ''[[SPINK5]]''. | *Damage from the [[Enzyme|enzymatic]] activity of [[allergens]] is usually prevented by the body's own [[protease inhibitor]]s, such as, ''[[LEKTI]]'', produced from the gene ''[[SPINK5]]''. | ||
*Lack of [[filaggrin]] [[gene]] causes [[dry skin]]. <ref name="pmid16550169">{{cite journal| author=Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP | display-authors=etal| title=Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. | journal=Nat Genet | year= 2006 | volume= 38 | issue= 4 | pages= 441-6 | pmid=16550169 | doi=10.1038/ng1767 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16550169 }} </ref> | *Lack of [[filaggrin]] [[gene]] causes [[dry skin]]. <ref name="pmid16550169">{{cite journal| author=Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP | display-authors=etal| title=Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. | journal=Nat Genet | year= 2006 | volume= 38 | issue= 4 | pages= 441-6 | pmid=16550169 | doi=10.1038/ng1767 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16550169 }} </ref> | ||
Revision as of 15:47, 21 June 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.
Overview
The etiology of eczema is multifactorial and complex. This involves aberrations in genetic component, adverse effect of certain medication and some environmental factors.
Etiology of Eczema
Genetic problem
- Damage from the enzymatic activity of allergens is usually prevented by the body's own protease inhibitors, such as, LEKTI, produced from the gene SPINK5.
- Lack of filaggrin gene causes dry skin. [1]
Common Medications with Eczema as the Adverse Drug Effect
- Below is a list of commonly prescribed medications with eczema as the common adverse drug effect (Table 1).
| Medication |
|---|
| Cidofovir |
| Flurbiprofen |
| Olaparib |
| Siltuximab |
| Sorafenib |
| Tiagabine |
References
- ↑ Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP; et al. (2006). "Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis". Nat Genet. 38 (4): 441–6. doi:10.1038/ng1767. PMID 16550169.