Eczema causes: Difference between revisions
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===Genetic problem=== | ===Genetic problem=== | ||
*Damage from the [[Enzyme|enzymatic]] activity of [[allergens]] is usually prevented by the body's own [[protease inhibitor]]s, such as | *Damage from the [[Enzyme|enzymatic]] activity of [[allergens]] is usually prevented by the body's own [[protease inhibitor]]s, such as ''[[LEKTI]]'', produced from the gene ''[[SPINK5]]''. | ||
*Lack of [[filaggrin]] [[gene]] causes [[dry skin]]. <ref name="pmid16550169">{{cite journal| author=Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP | display-authors=etal| title=Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. | journal=Nat Genet | year= 2006 | volume= 38 | issue= 4 | pages= 441-6 | pmid=16550169 | doi=10.1038/ng1767 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16550169 }} </ref> | *Lack of [[filaggrin]] [[gene]] causes [[dry skin]]. <ref name="pmid16550169">{{cite journal| author=Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP | display-authors=etal| title=Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. | journal=Nat Genet | year= 2006 | volume= 38 | issue= 4 | pages= 441-6 | pmid=16550169 | doi=10.1038/ng1767 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16550169 }} </ref> | ||
Revision as of 17:34, 14 July 2022
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Eczema Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Eczema On the Web |
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American Roentgen Ray Society Images of Eczema |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.
Overview
The etiology of eczema is multifactorial and complex. This involves aberrations in genetic component, adverse effect of certain medication and some environmental factors.
Etiology of Eczema
Genetic problem
- Damage from the enzymatic activity of allergens is usually prevented by the body's own protease inhibitors, such as LEKTI, produced from the gene SPINK5.
- Lack of filaggrin gene causes dry skin. [1]
Eczema as an Adverse Drug Reaction
- Eczema can also be brought about by some adverse effects of medications.
- Below is a list of commonly prescribed medications with eczema as the common adverse drug effect (Table 1).
| Medication |
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| Cidofovir |
| Flurbiprofen |
| Olaparib |
| Siltuximab |
| Sorafenib |
| Tiagabine |
References
- ↑ Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP; et al. (2006). "Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis". Nat Genet. 38 (4): 441–6. doi:10.1038/ng1767. PMID 16550169.