Beta-thalassemia history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]

History and Symptoms

Major variant patients present in early infancy with severe anemia, failure to thrive, pallor, jaundice, fatigue, and growth retardation. After treatment initiation, they would have symptoms of iron overload due to multiple transfusions, as well as fatigue and weakness, arthritis, abdominal pain, bronzed or grayish skin, loss of libido, hormonal imbalances, and cognitive problems. Intermedia variant patients might experience moderate anemia, splenomegaly, bone changes, and intermittent need for blood transfusions at different ages

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