Beta-thalassemia natural history, complications and prognosis: Difference between revisions
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==Natural history== | ==Natural history== | ||
Untreated [[beta-thalassemia]] can also result in significant morbidity, mortality, and diminished quality of life. Patients with non-transfusion-dependent [[beta-thalassemia]] (NTD) can develop a wide range of complications in critical organ systems due to ineffective [[erythropoiesis]], [[hemolysis]], and primary [[iron overload]] | Untreated [[beta-thalassemia]] can also result in significant morbidity, mortality, and diminished quality of life. Patients with non-transfusion-dependent [[beta-thalassemia]] (NTD) can develop a wide range of complications in critical organ systems due to ineffective [[erythropoiesis]], [[hemolysis]], and primary [[iron overload]]. NTD patients can progress to transfusion-dependent beta-thalassemia (TD) later in life, which further exacerbates the risk of complications and [[iron overload]] | ||
==Complications== | ==Complications== | ||
Revision as of 06:56, 25 August 2023
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Maryam Hadipour, M.D.[2]
Overview
Without regular blood transfusions, affected individuals by major beta-thalassemia typically develop severe anemia and related complications early in life, while beta-thalassemia intermedia patients would have a variable clinical course, complications, and prognosis. Beta-thalassemia minor subjects would not have significant symptoms, while in some cases might have an increased risk for iron deficiency anemia. Iron overload complications happen in transfusion-dependent thalassemia.
Natural history
Untreated beta-thalassemia can also result in significant morbidity, mortality, and diminished quality of life. Patients with non-transfusion-dependent beta-thalassemia (NTD) can develop a wide range of complications in critical organ systems due to ineffective erythropoiesis, hemolysis, and primary iron overload. NTD patients can progress to transfusion-dependent beta-thalassemia (TD) later in life, which further exacerbates the risk of complications and iron overload