Reticular fiber: Difference between revisions
Brian Blank (talk | contribs) No edit summary |
Brian Blank (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
{{SI}} | {{SI}} | ||
{{EH}} | {{EH}} | ||
==Overview== | ==Overview== | ||
'''Reticular fibers''' or '''reticulin''' is a [[histology|histological]] term used to describe a type of structural fiber composed of type III [[collagen]]. Reticular fibers crosslink to form a fine meshwork (reticulum). This network acts as a supporting mesh in soft tissues such as [[liver]], [[bone marrow]], and the tissues and organs of the [[lymphatic system]].<ref>Burkitt et al., ''Wheater's Functional Histology, 3rd ed.'' (Churchill Livinstone), p. 62</ref> | '''Reticular fibers''' or '''reticulin''' is a [[histology|histological]] term used to describe a type of structural fiber composed of type III [[collagen]]. Reticular fibers crosslink to form a fine meshwork (reticulum). This network acts as a supporting mesh in soft tissues such as [[liver]], [[bone marrow]], and the tissues and organs of the [[lymphatic system]].<ref>Burkitt et al., ''Wheater's Functional Histology, 3rd ed.'' (Churchill Livinstone), p. 62</ref> | ||
Revision as of 14:44, 5 June 2009
|
WikiDoc Resources for Reticular fiber |
|
Articles |
|---|
|
Most recent articles on Reticular fiber Most cited articles on Reticular fiber |
|
Media |
|
Powerpoint slides on Reticular fiber |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Reticular fiber at Clinical Trials.gov Trial results on Reticular fiber Clinical Trials on Reticular fiber at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Reticular fiber NICE Guidance on Reticular fiber
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Reticular fiber Discussion groups on Reticular fiber Patient Handouts on Reticular fiber Directions to Hospitals Treating Reticular fiber Risk calculators and risk factors for Reticular fiber
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Reticular fiber |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.
Overview
Reticular fibers or reticulin is a histological term used to describe a type of structural fiber composed of type III collagen. Reticular fibers crosslink to form a fine meshwork (reticulum). This network acts as a supporting mesh in soft tissues such as liver, bone marrow, and the tissues and organs of the lymphatic system.[1]
History
The term reticulin was coined in 1892 by M. Siegfried.[2]
Today the term reticulin or reticular fiber is restricted to fibers composed of type III collagen. However, during the pre-molecular era, there was confusion in the use of the term 'reticulin', which was used to describe two structures:
- the argyrophilic (silver staining) fibrous structures present in basement membranes
- histologically similar fibers present in developing connective tissue[3].
The history of the reticulin silver stain is reviewed by Puchtler et al. (1978).[4] The abstract of this paper says:
Maresch (1905) introduced Bielschowsky's silver impregnation technic for neurofibrils as a stain for reticulum fibers, but emphasized the nonspecificity of such procedures. This lack of specificity has been confirmed repeatedly. Yet, since the 1920's the definition of "reticulin" and studies of its distribution were based solely on silver impregnation technics. The chemical mechanism and specificity of this group of stains is obscure. Application of Gomori's and Wilder's methods to human tissues showed variations of staining patterns with the fixatives and technics employed. Besides reticulum fibers, various other tissue structures, e.g. I bands of striated muscle, fibers in nervous tissues, and model substances, e.g. polysaccharides, egg white, gliadin, were also stained. Deposition of silver compounds on reticulum fibers was limited to an easily removable substance; the remaining collagen component did not bind silver. These histochemical studies indicate that silver impregnation technics for reticulum fibers have no chemical significance and cannot be considered as histochemical technics for "reticulin" or type III collagen.
Structure
Reticular fiber one or more types of very thin and delicately woven strands of type III collagen, these strands build a highly ordered cellular network and provide a supporting network. Many of these types of collagen have been combined with carbohydrate. Thus, they react with silver stains and with periodic acid-Schiff reagent but are not demonstrated with ordinary histological stains such as those using hematoxylin. The 1953 science article mentioned above concluded that the reticular and regular collagenous materials contained the same four sugars - galactose, glucose, mannose and fucose - but in a much greater concentration in the reticular than the collagenous material.
In a 1993 paper [5] the reticular fibers of the capillary sheath and splenic cord were studied and compared in the pig spleen by transmission electron microscopy. This paper attempted to reveal their components and the presence of sialic acid in the amorphous ground substance. Collagen fibrils, elastic fibers, microfibrils, nerve fibers and smooth muscle cells were observed in the reticular fibers of the splenic cord. On the other hand, only microfibrils were recognized in the reticular fibers of the capillary sheath. The binding of LFA lectin to the splenic cord was stronger than the capillary sheath. These findings suggested that the reticular fibers of the splenic cord included multiple functional elements and might perform an important role during contraction or dilation of the spleen. On the other hand, the reticular fiber of the capillary sheath resembled the basement membrane of the capillary in its components.
External links
- Reticulin at the US National Library of Medicine Medical Subject Headings (MeSH)
- Template:EMedicineDictionary
- Template:LoyolaMedEd
References
- ↑ Burkitt et al., Wheater's Functional Histology, 3rd ed. (Churchill Livinstone), p. 62
- ↑ Siegfried, M. Habilitationaachrift. Leipzig: F.A. Brockhaus (1892), cited in Glegg et al (1953) "Some carbohydrate components of Reticular Fibers." Science, New series, vol 118, No 3073 (Nov 20, 1953), pp. 614-616 http://www.jstor.org/view/00368075/ap993073/99a00040/0
- ↑ JACKSON, D.S. and G. WILLIAMS, Nature of reticulin, 178(4539), 915, 1956. http://www.nature.com/nature/journal/v178/n4539/abs/178915b0.html
- ↑ Puchtler, H. and F.W. Waldrop, Silver impregnation methods for reticulum fibers and reticulin: A re-investigation of their origins and specificity, Histochemistry, 57(3), 177, 1978.
- ↑ Miyata, H., M. Abe, K. Takehana, K. Iwasa and T. Hiraga, Electron microscopic studies on reticular fibers in the pig sheathed artery and splenic cords, J Vet Med Sci, 55(5), 821, 1993.