Transposition of the great vessels pathophysiology

Transposition of the great vessels Microchapters
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Dextro-transposition of the great arteries
L-transposition of the great arteries
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: Priyamvada Singh, M.B.B.S. [2]; Cafer Zorkun, M.D., Ph.D. [3]; Keri Shafer, M.D. [4]; Assistant Editor(s)-In-Chief: Kristin Feeney, B.S. [5]

Pathophysiology

In normal cardiac anatomy, the aorta is positioned posterior and to the right of the main pulmonary artery. aorta being positioned anterior and slightly rightward of the pulmonary artery. These changes cause the aorta to arise from the right ventricle and the pulmonary artery from the left ventricle (ventriculoarterial discordance).

• Simple D-TGA describes patients without another cardiac defects
• complex TGA describes those with an additional cardiac lesion.other cardiac defects that could be seen in dextro-TGA are
  • Ventricular septal defect (VSD) (in about 50%) of patients with D-TGA. Patients with a VSD may have other cardiac anomalies like pulmonary stenosis or atresia, overriding of atrioventricular valve, and coarctation of aorta.
  • Left ventricular outflow tract obstruction is common in D-TGA and is present in up to 25 percent of patients [11].

External links

• Diagram at kumc.edu
• Diagram and description at umich.edu
• Royal Children's Hospital, Melbourne
• Mayo Clinic, Arizona - Florida - Minnesota, USA